Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Skeletal Growth
Discussion Leader: Andrea Vortkamp (University of Duisburg-Essen, Germany)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
Kim Cooper (University of California, San Diego, USA)
"Control of Differential Growth Rates in Development and Evolution to Establish Skeletal Proportion"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Elazar Zelzer (Weizmann Institute of Science, Israel)
"Pyruvate Dehydrogenase Kinase and Bone Hypoxia"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Oliver Pourquie (Harvard Medical School / Brigham and Women's Hospital, USA)
"New Insights into Human Spine Patterning"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cartilage Development
Discussion Leader: Henry Kronenberg (Massachusetts General Hospital / Harvard Medical School, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
David Ornitz (Washington University in St. Louis, USA)
"Regulation of Osteogenic and Chondrogenic Growth Programs by FGF Signaling Pathways"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Karen Lyons (University of California, Los Angeles, USA)
"The Type I Tgfβ Receptor Functions as an Antagonist of BMP Signaling in Cartilage"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Chenghai Zhang (Harvard Medical School, USA)
"Creb5 Regulates the Formation of Many Synovial Joints and Maintains the Expression of Lubricin in Articular Chondrocytes"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Veronique Lefebvre (Children's Hospital of Philadelphia, USA)
"Dissecting the Transactivation and Other Activities of the Master Chondrogenic Factor SOX9"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Ernestina Schipani (University of Michigan, USA)
"Mitochondria and HIFs in Skeletal Development"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
April Craft (Boston Children's Hospital / Harvard Medical School, USA)
"Identifying Signals for Joint Cartilage Specification Using Novel ES Cell Models"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Yingzi Yang (Harvard School of Dental Medicine, USA) and Karen Lyons (University of California, Los Angeles, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetic and Epigenetic Programming
Discussion Leader: Andrew Lassar (Harvard Medical School, USA)
7:30 pm - 7:55 pm
Regis O'Keefe (Washington University in St. Louis, USA)
"Epigenetic Regulation of Cartilage Energy Metabolism and Tissue Catabolism"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Shinsuke Ohba (The University of Tokyo, Japan)
"Exploring the Gene Regulatory Landscape in Skeletal Cells"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Scott Stadler (Shriners Hospital / Oregon Health & Science University, USA)
"An Epigenetic Program Mediated by lncRNA-HIT Is Essential for the Maturation and Homeostasis of Articular Cartilage"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Nora Renthal (Boston Children's Hospital, USA)
"Translating Human Height Genetics to Skeletal Biology by Functional Genomics of the Growth Plate"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Fred Berry (University of Alberta, Canada)
"Foxc1 and Foxc2 Are Required for Growth Plate Organization and Endochondral Bone Formation"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanobiology of Cartilage and Joints
Discussion Leader: Farshid Guilak (Washington University in St. Louis, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Kate Poole (University of New South Wales, Australia)
"Mechanical Activation and Modulation of TRPV4 and PIEZO1 at the Cell-Substrate Interface"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Robert Mauck (University of Pennsylvania, USA)
"The Role of Nuclear Mechanobiology in Mesenchymal Progenitor Cell Differentiation and Tissue Repair"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Danielle Rux (Children's Hospital of Philadelphia, USA)
"Primary Cilia Drive Postnatal Articular Cartilage Morphogenesis by Controlling Proteoglycan Production and Chondrocyte Organization"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Tamara Alliston (University of California, San Francisco, USA)
"Bone/Cartilage Crosstalk in Joint Disease"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Michael Longaker (Stanford University, USA)
"Mechanoresponsive Skeletal Stem Cells in Bone Regeneration"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Kelsey Collins (Washington University in St. Louis, USA)
"A Fat-Free Mouse Model to Study the Contributions of Metabolic Disturbance to Cartilage Physiology and Pathology"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cartilage Matrix
Discussion Leader: Danny Chan (The University of Hong Kong, Hong Kong SAR China)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Alexandra Naba (University of Illinois at Chicago, USA)
"Bioinformatic and Proteomic Approaches to Characterize the ECM of Tissues in Health and Disease"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
David Wilkinson (Newcastle University, United Kingdom)
"Endogenous Serine Proteinase Inhibitors in Cartilage Protection and Chondrogenesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Blandine Poulet (University of Liverpool, United Kingdom)
"Effects of Fibrillin-1 Mutations on Joint Health"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Sarah Calve (Purdue University, USA)
"Perlecan Knockdown Significantly Alters ECM Assembly During Cartilage Development"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Tamas Juhasz (University of Debrecen, Hungary)
"Disturbed Cartilage Matrix Composition and Altered PKA-Regulated Transcription Factor Expression in Articular Cartilage of PACAP and PAC1 Gene Deficient Mice"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic Cartilage Disease
Discussion Leader: Michael Briggs (Newcastle University, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Brendan Lee (Baylor College of Medicine, USA)
"Transcriptional and Replication Defects in Human Chondrodysplasias"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Maurizio Pacifici (The Children's Hospital of Philadelphia, USA)
"Extraskeletal Cartilage Formation in a Congenital Pediatric Disorder: Mechanisms and Treatment"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Prem Yadav (Harvard University, USA)
"Deciphering the Role of Stat3 Dependent Bone Development in the Context of Job Syndrome"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Matthew Warman (Boston Children's Hospital / Harvard University, USA)
"The Role of Superficial Zone Chondrocytes in Articular Cartilage"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Valerie Cormier-Daire (Paris Descartes University, INSERM U1163, France)
"GAG Synthesis Impairment in the Group of Chondrodysplasia with Multiple Dislocations"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Anders Aspberg (Lund University, Sweden)
"Proximity Labelling Proteomics Reveals Intracellular Effects of Pathogenic Aggrecan Gene Variant Expression"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cartilage Degeneration
Discussion Leader: Benjamin Alman (Duke University, USA)
7:30 pm - 7:55 pm
Joyce van Meurs (Erasmus MC, The Netherlands)
"Large Scale Genetic Studies Highlight Diverse Biological Pathways Involved in Cartilage Degeneration"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Frank Beier (University of Western Ontario, Canada)
"Control of Cartilage Homeostasis by the Chromatin Regulator CTCF"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Jennifer Elisseeff (Johns Hopkins University, USA)
"Lessons from Translation: New Targets for Cartilage Repair"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Ling Qin (University of Pennsylvania, USA)
"Regulatory Role of EGFR Signaling in Adult Cartilage Homeostasis and Osteoarthritis"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells and Cartilage Regeneration
Discussion Leader: Christine Hartmann (University of Münster, Germany)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Noriaki Ono (University of Michigan School of Dentistry, USA)
"Resting Zone of the Growth Plate Houses a Unique Class of Skeletal Stem Cells"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Hiroshi Asahara (Tokyo Medical and Dental University, Japan / Scripps Research, USA)
"Cartilage Development and Homeostasis via Pre- and Post-Transcriptional Regulation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Deneen Wellik (University of Wisconsin-Madison, USA)
"Hox Function in the Adult Limb Skeleton"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Xu Cao (Johns Hopkins University, USA)
"Sclerosis of Cartilaginous Endplate Causes Spine Pain"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Ronen Schweitzer (Shriners Research Center, USA)
"Disruption of TGFb Signaling in the Scleraxis Cell Lineage Results in Tenocyte Dedifferentiation and Tendon Progenitor Recruitment"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Kathryn Cheah (The University of Hong Kong, Hong Kong SAR China)
"Insights into the Cellular Basis of Intervertebral Disc Disease Gained from the t-Transcriptomes of Single Cells"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Approaches to Cartilage Therapies
Discussion Leader: Frank Zaucke (Orthopaedic University Hospital Friedrichsheim, Germany)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Jacqueline Hecht (The University of Texas Health Science Center at Houston, USA)
"Mechanism-Driven Treatment Approach for Compopathy/Pseudoachondroplasia"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Raymond Boot-Handford (Wellcome Centre for Cell-Matrix Research, United Kingdom)
"Stimulation of Intracellular Proteolysis as a Treatment Trategy for Dwarfism Caused by Mutations in Type X Collagen"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Leia Shuhaibar (UConn Health, USA)
"Phosphatase Inhibitors Enhance cGMP Production by NPR2 in Growth Plate Chondrocytes and Could Potentially Be Used to Rescue Bone Growth in Achondroplasia"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Vishal Deshmukh (Samumed, LLC, USA)
"SM04690, a Potential Disease-Modifying Treatment for Knee Osteoarthritis, Functions Through Inhibition of CLK2 and DYRK1A, Novel M"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Laurence Legeai-Mallet (Institut Imagine, INSERM U1163, France)
"Theobroma Cacao Extracts as a Treatment for FGFR3-Related Disorders"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure