Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"Control of Differential Growth Rates in Development and Evolution to Establish Skeletal Proportion"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Pyruvate Dehydrogenase Kinase and Bone Hypoxia"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"New Insights into Human Spine Patterning"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Regulation of Osteogenic and Chondrogenic Growth Programs by FGF Signaling Pathways"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The Type I Tgfβ Receptor Functions as an Antagonist of BMP Signaling in Cartilage"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Creb5 Regulates the Formation of Many Synovial Joints and Maintains the Expression of Lubricin in Articular Chondrocytes"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Dissecting the Transactivation and Other Activities of the Master Chondrogenic Factor SOX9"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Mitochondria and HIFs in Skeletal Development"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Identifying Signals for Joint Cartilage Specification Using Novel ES Cell Models"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetic and Epigenetic Programming
7:30 pm - 7:55 pm
"Epigenetic Regulation of Cartilage Energy Metabolism and Tissue Catabolism"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Exploring the Gene Regulatory Landscape in Skeletal Cells"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"An Epigenetic Program Mediated by lncRNA-HIT Is Essential for the Maturation and Homeostasis of Articular Cartilage"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Translating Human Height Genetics to Skeletal Biology by Functional Genomics of the Growth Plate"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Foxc1 and Foxc2 Are Required for Growth Plate Organization and Endochondral Bone Formation"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanobiology of Cartilage and Joints
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Mechanical Activation and Modulation of TRPV4 and PIEZO1 at the Cell-Substrate Interface"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The Role of Nuclear Mechanobiology in Mesenchymal Progenitor Cell Differentiation and Tissue Repair"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Primary Cilia Drive Postnatal Articular Cartilage Morphogenesis by Controlling Proteoglycan Production and Chondrocyte Organization"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Bone/Cartilage Crosstalk in Joint Disease"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Mechanoresponsive Skeletal Stem Cells in Bone Regeneration"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"A Fat-Free Mouse Model to Study the Contributions of Metabolic Disturbance to Cartilage Physiology and Pathology"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Bioinformatic and Proteomic Approaches to Characterize the ECM of Tissues in Health and Disease"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Endogenous Serine Proteinase Inhibitors in Cartilage Protection and Chondrogenesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Effects of Fibrillin-1 Mutations on Joint Health"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Perlecan Knockdown Significantly Alters ECM Assembly During Cartilage Development"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Disturbed Cartilage Matrix Composition and Altered PKA-Regulated Transcription Factor Expression in Articular Cartilage of PACAP and PAC1 Gene Deficient Mice"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic Cartilage Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Transcriptional and Replication Defects in Human Chondrodysplasias"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Extraskeletal Cartilage Formation in a Congenital Pediatric Disorder: Mechanisms and Treatment"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Deciphering the Role of Stat3 Dependent Bone Development in the Context of Job Syndrome"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"The Role of Superficial Zone Chondrocytes in Articular Cartilage"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"GAG Synthesis Impairment in the Group of Chondrodysplasia with Multiple Dislocations"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Proximity Labelling Proteomics Reveals Intracellular Effects of Pathogenic Aggrecan Gene Variant Expression"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Large Scale Genetic Studies Highlight Diverse Biological Pathways Involved in Cartilage Degeneration"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Control of Cartilage Homeostasis by the Chromatin Regulator CTCF"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Lessons from Translation: New Targets for Cartilage Repair"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Regulatory Role of EGFR Signaling in Adult Cartilage Homeostasis and Osteoarthritis"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells and Cartilage Regeneration
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Resting Zone of the Growth Plate Houses a Unique Class of Skeletal Stem Cells"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Cartilage Development and Homeostasis via Pre- and Post-Transcriptional Regulation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Hox Function in the Adult Limb Skeleton"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Sclerosis of Cartilaginous Endplate Causes Spine Pain"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Disruption of TGFb Signaling in the Scleraxis Cell Lineage Results in Tenocyte Dedifferentiation and Tendon Progenitor Recruitment"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Insights into the Cellular Basis of Intervertebral Disc Disease Gained from the t-Transcriptomes of Single Cells"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Approaches to Cartilage Therapies
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Mechanism-Driven Treatment Approach for Compopathy/Pseudoachondroplasia"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Stimulation of Intracellular Proteolysis as a Treatment Trategy for Dwarfism Caused by Mutations in Type X Collagen"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Phosphatase Inhibitors Enhance cGMP Production by NPR2 in Growth Plate Chondrocytes and Could Potentially Be Used to Rescue Bone Growth in Achondroplasia"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"SM04690, a Potential Disease-Modifying Treatment for Knee Osteoarthritis, Functions Through Inhibition of CLK2 and DYRK1A, Novel M"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Theobroma Cacao Extracts as a Treatment for FGFR3-Related Disorders"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure