Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Cartilage Development and Regeneration
Discussion Leader: Terence Capellini (Harvard University, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Deneen Wellik (University of Wisconsin-Madison, United States)
"Loss of Hox11 Function Results in Disrupted Osteochondral Differentiation in Response to Fracture"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Christine Hartmann (University of Münster, Germany)
"Insights Into Bone Marrow Cavity Formation"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Aris Economides (Regeneron Pharmaceuticals, Inc., United States)
"Skeletal Patterning Defects in Fibrodysplasia Ossificans Progressiva (FOP) are Dependent on Activation of FOP-Mutant ACVR1 by Activin A"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Fadia Kamal (Penn State College of Medicine, United States)
"GRK2: A Novel Regulator of Endochondral Ossification and Postnatal Skeletal Development"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Véronique Lefebvre (Children's Hospital of Philadelphia, United States)
"Chondrogenic Roles and Properties of SOX8"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics and Non-Coding RNAs
Discussion Leader: Louise Reynard (Newcastle University Biosciences Institute, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Yolande Ramos (Leiden University Medical Center, The Netherlands)
"Leveraging Epigenetics in OA: Opportunities to Bridge the Translational Gap"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Audrey McAlinden (Washington University, United States)
"Targeting MicroRNAs to Treat Orthopaedic Conditions: Lessons from Limb Development"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Adam Farrier (Newcastle University, United Kingdom)
"TRAF3IP2 Perturbation in Human Articular Chondrocytes Reverses IL17 Induced OA-like Transcriptional Changes"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Sade Clayton (Washington University in St. Louis, United States)
"Multi-modal Transcriptomic Analyses of the Mouse Intervertebral Disc Following Injury Reveals a Temporally Distinct Cascade of Infiltrating Immune Cells"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Terence Capellini (Harvard University, United States)
"Uncovering the Transcriptomic, Epigenomic, and Spatial Profiles of the Developing Human Pelvic Girdle at a Single Cell Level"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Divya Venkatasubramanian (Harvard University, Boston Children's Hospital, United States)
"Gene Regulatory Networks Governing Human Articular and Growth Plate Chondrocyte Development"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Sarah Rice (Newcastle University, United Kingdom)
"Collagen-Modifying Enzyme COLGALT2 as a Mediator of Osteoarthritis Risk"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Francesco Dell'Accio (Queen Mary, University of London, United Kingdom)
"From Regenerative Morphogenesis to Novel Therapeutics in Osteoarthritis"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Sarah Snelling (University of Oxford, United Kingdom), Rosa Serra (University of Alabama at Birmingham, United States) and Gerjo Van Osch (Erasmus MC, University Medical Center Rotterdam, The Netherlands)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Extracellular Matrix
Discussion Leader: Antonio Rossi (University of Pavia - Department of Molecular Medicine, Italy)
6:00 pm - 6:20 pm
Bent Brachvogel (University of Cologne, Germany)
"Metabolism, Skeletal Development and Extracellular Matrix Homeostasis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Blandine Poulet (University of Liverpool, United Kingdom)
"Effects of Fibrillin-1 Deficiency on Osteoarthritis Development"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Sarah Calve (University of Colorado Boulder, United States)
"Visualization of ECM Dynamics During Limb Development"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Dirk Hubmacher (Icahn School of Medicine at Mount Sinai, United States)
"ADAMTS10 and ADAMTS17 Cooperate in Regulating Growth Plate Activity Through Extracellular Matrix Modulation Independent of their Proteolytic Activities"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Jos Malda (UMC Utrecht, The Netherlands)
"Collagen Structures: What Can We Learn From Other Species?"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanobiology
Discussion Leader: Louis DeFrate (Duke University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Andrew Pitsillides (Royal Veterinary College, United Kingdom)
"Imaging Endochondral Interactions Across the Mineralised Phase"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Angus Wann (Kennedy Institute, University of Oxford, United Kingdom)
"Exploring Mechano-Tolerance, Mechano-plasticity and Matrix Remodelling by Targeting the Chondrocyte Ciliome"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Sofia Gonzalez-Nolde (University of Delaware, United States)
"F-actin Reorganization Regulates Cartilage Lubricating Protein, Proteoglycan-4 in Native Superficial Zone Chondrocytes"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Niamh Nowlan (University College Dublin, Ireland)
"Biology and Mechanobiology of Cartilage Development"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Ronald June (Montana State University, United States)
"Mechanotransduction and Metabolism of Articular Chondrocytes"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Qing-Jun Meng (University of Manchester, United Kingdom)
"Daily Mechanical Loading and Osmotic Cycles Reset the Circadian Clocks in Cartilage and Intervertebral Discs"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Joanna Sherwood (University Hospital Münster, Germany)
"Transient Receptor Potential Channel 1 (TRPC1) Links Intracellular Calcium Signaling to Cellular Senescence and is Involved in Osteoarthritis Development"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Biomechanics and Bioengineering
Discussion Leader: Corey Neu (University of Colorado Boulder, United States)
6:00 pm - 6:20 pm
Gerard Ateshian (Columbia University, United States)
"How Stress Mediates Cartilage Wear and the Progression of Tissue Degeneration"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Suzanne Maher (Hospital for Special Surgery, United States)
"Mechanical Phenotyping of Knees: Where we Stand Makes a Difference"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Daniela Mählich (German Sport University Cologne, Germany)
"Plastin-3 Contributes to Mechanosensing in Articular Cartilage"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Markus Wimmer (Rush University Medical Center, United States)
"The Ionic Phase in Cartilage and its Influence on Tissue Tribology"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Katherine Arnold (Mayo Clinic, United States)
"Phlpp1 and Articular Cartilage Tissue Quality in Osteoarthritis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells, Tissue Engineering, and Differentiation
Discussion Leader: Brian Johnstone (Oregon Health & Science University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Rhima Coleman (University of Michigan, United States)
"Anti-Hypertrophic and Anti-Inflammatory Effects of Autonomous RUNX2 Suppression in Engineered Cartilage"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Francis Berenbaum (Sorbonne University, France)
"Glucagon-like Peptide-1 Analogues: Metabolic Roles and Beyond"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Suzanne Eldridge (William Harvey Research Institute, United Kingdom)
"Disease Modification and Symptom Relief in Osteoarthritis Using a Mutated GCP-2/CXCL6 Chemokine"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Solvig Diederichs (Heidelberg University Hospital, Germany)
"Untangling the Signaling Pathways that Direct Chondral Versus Endochondral Cell Differentiation"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Denis Evseenko (USC, United States)
"Inhibition of a Signaling Modality Within Gp130 Receptor Enhances Tissue Regeneration and Mitigates Osteoarthritis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Roberto Narcisi (Erasmus MC, The Netherlands)
"Impact of Cellular Senescence on Stem Cells Chondrogenic Differentiation"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Dana Trompet (Gothenburg University, Sweden)
"Local and Transient Stimulation of Skeletal Stem Cells in the Growth Plate Causes Leg Length Discrepancy"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Osteoarthritis
Discussion Leader: Anne-Marie Malfait (Rush University Medical Center, United States)
6:00 pm - 6:20 pm
Carla Scanzello (University of Pennsylvanit, United States)
"The Role of Pattern-Recognition in Osteoarthritis Pathology and Joint Pain"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
MONA Dvir-Ginzberg (Hebrew University of Jerusalem, Israel)
"Assessing the Role of SIRT1 Cleavage in OA Pathogenesis"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Magdalena Kaneva (William Harvey Research Institute, QMUL, United Kingdom)
"Repurposing Alpha-1-Antitrypsin as a Treatment of Osteoarthritis"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Eleftheria Zeggini (Helmholtz Munich, Germany)
"Translational Genomics of Osteoarthritis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Mohit Kapoor (Schroeder Arthritis Institute, University Health Network, Canada)
"Multi-Omic Profiling in Osteoarthritis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Rare Diseases, Disease Modeling and Aging
Discussion Leader: Uwe Kornak (University Medical Center Göttingen, Germany)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Shireen Lamande (Murdoch Children's Research Institute, Australia)
"Modelling Skeletal Disorders using Human Induced Pluripotent Stem Cells"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Katarzyna Pirog (Newcastle University, United Kingdom)
"Dissecting the Role of Kif22 in Skeletal Development and Health"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Alice Stephan (University of Cologne, Germany)
"Homozygous Kdelr2-Mutant Mice Display Defects in Endochondral and Intramembranous Bone Formation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Alessandra Leone (Università degli Studi di Pavia; Istituto Universitario di Studi Superiori (IUSS), Pavia, Italy)
"Calcium-Activated Nucleotidase 1 Impairment Affects Proteoglycan Synthesis and Cell Homeostasis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Brian Diekman (Univ North Carolina / NC State, United States)
"DNA Damage and Cellular Senescence in Osteoarthritis Pathophysiology"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Christopher Little (University of Sydney, Australia)
"Inflammation and Immunobiology of Joint Injury and Osteoarthritis Risk"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Danielle Rux (Children's Hospital of Philadelphia, United States)
"Superficial Zone Cell Death in Adult Mouse Joints Leads to Early Onset Osteoarthritic Progression"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cartilaginous and Joint Tissues
Discussion Leader: Susanne Graessel (University of Regensburg, Germany)
6:00 pm - 6:20 pm
Devina Purmessur (Walter) (The Ohio State University, United States)
"Non-viral Gene Delivery of Development Factors to Treat Discogenic Back Pain"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Martin Englund (Lund University, Sweden)
"Why Ultrastructure of Extracellular Matrix of Cartilage Matters"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Danny Chan (The University of Hong Kong, Hong Kong SAR China)
"CDO-Associated Apoptosis in Synovial Joint Formation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Chia-Lung Wu (University of Rochester School of Medicine and Dentistry -, United States)
"Integrated scRNA-seq and Spatial Transcriptomics Analysis Uncovers Distinct Cellular Populations and Transcriptomes in Human Hip Synovium Between Patients With FAI and OA"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Arin Oestreich (Washington University School of Medicine Department of Orthopedic Surgery, United States)
"Maternal Transgenic Conversion of Omega-6 to Omega-3 Fatty Acids Enhances Fetal Growth and Mitigates Adult Offspring Pain Behavior in an Injury-induced Osteoarthritis Model"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
