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Cartilage Biology and Pathology

Gordon Research Conference

Cartilage Biology, Structure and Function: From Development to Regeneration

March 19 - 24, 2023

Chairs

and

Vice Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The Cartilage Biology and Pathology GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The GRC on Cartilage Biology and Pathology covers a broad range of topics and new technologies as cartilage is not only the earliest skeletal tissue that supports skeletal development from embryos to adulthood, but also serves an essential skeletal component of a functional adult skeletal system. In this regard, diseases that result in cartilage malformation or degeneration significantly affect the lifespan and quality of life of a large part of the population. The GRC will highlight recent advances and challenges in understanding cartilage biology and diseases. Established scientists and talented new investigators will report and discuss their most recent exciting findings according to this theme and will provide insights into the remaining challenges towards understanding the various aspects of cartilage biology, disease, and translational approaches. We expect the 2023 GRC on Cartilage Biology and Pathology to empower researchers across disciplines to make significant progress towards understanding cartilage biology and improving human health.

Related Meeting

This GRC will be held in conjunction with the "Cartilage Biology and Pathology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Cartilage Development and Regeneration Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Loss of Hox11 Function Results in Disrupted Osteochondral Differentiation in Response to Fracture"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Insights Into Bone Marrow Cavity Formation"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Skeletal Patterning Defects in Fibrodysplasia Ossificans Progressiva (FOP) are Dependent on Activation of FOP-Mutant ACVR1 by Activin A"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"GRK2: A Novel Regulator of Endochondral Ossification and Postnatal Skeletal Development"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Chondrogenic Roles and Properties of SOX8"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Epigenetics and Non-Coding RNAs Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Leveraging Epigenetics in OA: Opportunities to Bridge the Translational Gap"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Targeting MicroRNAs to Treat Orthopaedic Conditions: Lessons from Limb Development"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	"TRAF3IP2 Perturbation in Human Articular Chondrocytes Reverses IL17 Induced OA-like Transcriptional Changes"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Multi-modal Transcriptomic Analyses of the Mouse Intervertebral Disc Following Injury Reveals a Temporally Distinct Cascade of Infiltrating Immune Cells"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:15 am	"Uncovering the Transcriptomic, Epigenomic, and Spatial Profiles of the Developing Human Pelvic Girdle at a Single Cell Level"
11:15 am - 11:20 am	Discussion
11:20 am - 11:30 am	"Gene Regulatory Networks Governing Human Articular and Growth Plate Chondrocyte Development"
11:30 am - 11:35 am	Discussion
11:35 am - 11:45 am	"Collagen-Modifying Enzyme COLGALT2 as a Mediator of Osteoarthritis Risk"
11:45 am - 11:50 am	Discussion
11:50 am - 12:10 pm	"From Regenerative Morphogenesis to Novel Therapeutics in Osteoarthritis"
12:10 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: , and
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Extracellular Matrix Discussion Leader:
6:00 pm - 6:20 pm	"Metabolism, Skeletal Development and Extracellular Matrix Homeostasis"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Effects of Fibrillin-1 Deficiency on Osteoarthritis Development"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	"Visualization of ECM Dynamics During Limb Development"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"ADAMTS10 and ADAMTS17 Cooperate in Regulating Growth Plate Activity Through Extracellular Matrix Modulation Independent of their Proteolytic Activities"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Collagen Structures: What Can We Learn From Other Species?"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Mechanobiology Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Imaging Endochondral Interactions Across the Mineralised Phase"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Exploring Mechano-Tolerance, Mechano-plasticity and Matrix Remodelling by Targeting the Chondrocyte Ciliome"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	"F-actin Reorganization Regulates Cartilage Lubricating Protein, Proteoglycan-4 in Native Superficial Zone Chondrocytes"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Biology and Mechanobiology of Cartilage Development"
11:10 am - 11:20 am	Discussion
11:20 am - 11:40 am	"Mechanotransduction and Metabolism of Articular Chondrocytes"
11:40 am - 11:50 am	Discussion
11:50 am - 12:00 pm	"Daily Mechanical Loading and Osmotic Cycles Reset the Circadian Clocks in Cartilage and Intervertebral Discs"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:15 pm	"Transient Receptor Potential Channel 1 (TRPC1) Links Intracellular Calcium Signaling to Cellular Senescence and is Involved in Osteoarthritis Development"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Biomechanics and Bioengineering Discussion Leader:
6:00 pm - 6:20 pm	"How Stress Mediates Cartilage Wear and the Progression of Tissue Degeneration"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Mechanical Phenotyping of Knees: Where we Stand Makes a Difference"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"Plastin-3 Contributes to Mechanosensing in Articular Cartilage"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:35 pm	"The Ionic Phase in Cartilage and its Influence on Tissue Tribology"
7:35 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Phlpp1 and Articular Cartilage Tissue Quality in Osteoarthritis"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Stem Cells, Tissue Engineering, and Differentiation Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Anti-Hypertrophic and Anti-Inflammatory Effects of Autonomous RUNX2 Suppression in Engineered Cartilage"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Glucagon-like Peptide-1 Analogues: Metabolic Roles and Beyond"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	"Disease Modification and Symptom Relief in Osteoarthritis Using a Mutated GCP-2/CXCL6 Chemokine"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Untangling the Signaling Pathways that Direct Chondral Versus Endochondral Cell Differentiation"
11:10 am - 11:20 am	Discussion
11:20 am - 11:40 am	"Inhibition of a Signaling Modality Within Gp130 Receptor Enhances Tissue Regeneration and Mitigates Osteoarthritis"
11:40 am - 11:50 am	Discussion
11:50 am - 12:00 pm	"Impact of Cellular Senescence on Stem Cells Chondrogenic Differentiation"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:15 pm	"Local and Transient Stimulation of Skeletal Stem Cells in the Growth Plate Causes Leg Length Discrepancy"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Osteoarthritis Discussion Leader:
6:00 pm - 6:20 pm	"The Role of Pattern-Recognition in Osteoarthritis Pathology and Joint Pain"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Assessing the Role of SIRT1 Cleavage in OA Pathogenesis"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Repurposing Alpha-1-Antitrypsin as a Treatment of Osteoarthritis"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Translational Genomics of Osteoarthritis"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Multi-Omic Profiling in Osteoarthritis"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Rare Diseases, Disease Modeling and Aging Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Modelling Skeletal Disorders using Human Induced Pluripotent Stem Cells"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Dissecting the Role of Kif22 in Skeletal Development and Health"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	"Homozygous Kdelr2-Mutant Mice Display Defects in Endochondral and Intramembranous Bone Formation"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Calcium-Activated Nucleotidase 1 Impairment Affects Proteoglycan Synthesis and Cell Homeostasis"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:25 am	"DNA Damage and Cellular Senescence in Osteoarthritis Pathophysiology"
11:25 am - 11:35 am	Discussion
11:35 am - 11:55 am	"Inflammation and Immunobiology of Joint Injury and Osteoarthritis Risk"
11:55 am - 12:05 pm	Discussion
12:05 pm - 12:15 pm	"Superficial Zone Cell Death in Adult Mouse Joints Leads to Early Onset Osteoarthritic Progression"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Cartilaginous and Joint Tissues Discussion Leader:
6:00 pm - 6:20 pm	"Non-viral Gene Delivery of Development Factors to Treat Discogenic Back Pain"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Why Ultrastructure of Extracellular Matrix of Cartilage Matters"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"CDO-Associated Apoptosis in Synovial Joint Formation"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Integrated scRNA-seq and Spatial Transcriptomics Analysis Uncovers Distinct Cellular Populations and Transcriptomes in Human Hip Synovium Between Patients With FAI and OA"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Maternal Transgenic Conversion of Omega-6 to Omega-3 Fatty Acids Enhances Fetal Growth and Mitigates Adult Offspring Pain Behavior in an Injury-induced Osteoarthritis Model"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute Of Arthritis And Musculoskeletal And Skin Diseases of the National Institutes of Health under Award Number R13AR082210. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Cartilage Biology and Pathology (GRS)

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