| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Insights into the Cure of Skeletal
Diseases |
| Discussion Leader: Pallavi Bhattaram (Cleveland Clinic, USA) |
| 3:45 pm - 4:15 pm | Bjorn Olsen (Harvard School of Dental Medicine, USA)
"At the Beginning, There Was Cartilage...." |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New
Discoveries in Cartilage Structure, Function, and Regulation from Development
to Aging |
| Discussion Leaders: Yingzi Yang (Harvard School of Dental Medicine, USA) and Solvig Diederichs (Heidelberg University Hospital, Germany) |
| 7:30 pm - 7:40 pm | Chia-Feng Liu (Cleveland Clinic Lerner Research Institute, USA)
"SOX9 and SOX5/SOX6 Interact Genome-Wide to Implement the Chondrocyte Differentiation Program" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 7:55 pm | George Coricor (University of Alabama, Birmingham, USA)
"Modulation of SOX9 by TGFβ Signaling and Its Effect on Chondrogenesis" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Amjad Askary (University of Southern California, USA)
"The Iroquois Transcription Factors Irx7 and Irx5a Promote Joint Development in Zebrafish by Arresting Chondrocyte Maturation at the Interzone" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Rebekah Decker (Children's Hosptial of Philadelphia, USA)
"New Insights into Mouse Limb Synovial Joint Morphogenesis Using Novel Cell Lineage Tracing Techniques" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Matthew Karolak (Vanderbilt University Medical Center, USA)
"FGFR1 Signaling in Hypertrophic Chondrocytes Is Attenuated by the Ras-GAP Neurofibromin During Endochondral Bone Formation" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Tatjana Holzer (Center for Biochemistry, Germany)
"mir-26a Modulates Extracellular Matrix Homeostasis in Cartilage" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Matthias Kamper (University of Cologne, Germany)
"Loss of Col IX Strongly Alters Spine Development and Leads to an Early Onset of Disc Degeneration" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Jennifer Zieba (University of California, Los Angeles, USA)
"Absence of FLNB Causes Vertebral Fusions Through Increased TGFβ/BMP Signaling and Ectopic Intervertebral Disc Ossification" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Mechanistic
Advances in Understanding Cartilage Diseases and Regeneration |
| Discussion Leaders: Frank Beier (Western University, Canada) and Blandine Poulet (University College London, United Kingdom) |
| 9:00 am - 9:10 am | Tiffany Au (The University of Hong Kong, China)
"Understanding the Molecular Impact of SOX9 Y440X in Campomelic Dysplasia" |
| 9:10 am - 9:15 am | Discussion |
| 9:15 am - 9:25 am | Ludovic Martin (Institut Imagine, France)
"Primary Cilia of the Cartilage Is Abnormal in FGFR3-Related Disorders" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:40 am | Honghao Zhang (University of Michigan, USA)
"Mutation in Ciliary Protein EVC2 Leads to Dwarfism Through Elevated FGF Signaling Mediated by Compromised Hedgehog Signaling and Elevated WNT Signaling" |
| 9:40 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Federica Sgariglia (Children's Hospital of Philadelphia, USA)
"Previously Unsuspected Defects in the Cranial Base of a Mouse Model of Hereditary Multiple Exostoses" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | Mateusz Kudelko (University of Hong Kong, China)
"Hypertrophic Chondrocytes Survive ER Stress by Maintaining Glycolysis and Mitochondrial Membrane Polarity" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Matthew McCann (Western University, Canada)
"Repeated Exposure to Whole-Body Vibration Negatively Affects Musculoskeletal Joints" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 10:40 am | Yang Wang (Massachusetts Institute of Technology, USA)
"Quantitative Proteomics Analysis of Phosphorylation Changes in Human Knee and Ankle Chondrocytes Following Treatment with IL-1, IGF-1, and Dexamethasone" |
| 10:40 am - 10:45 am | Discussion |
| 10:45 am - 10:55 am | Hidetoshi Tsushima (Duke University, USA)
"Kynurenine and Kynurenic Acid Metabolites Demonstrate Protective Effects on Cartilage Degeneration" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Art of Publishing and Obtaining Funding |
| Discussion Leader: Wilson Chan (University of Hong Kong, China) |
| 1:30 pm - 2:00 pm | Philippe Soriano (Mount Sinai School of Medicine, USA)
"Tips to Build an Independent Scientific Career" |
| 2:00 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
