Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Genetic and Immunological Approaches to Cartilage and Extracellular Matrix Dysregulation
Discussion Leader: Matthew McCann (Columbia University, USA)
3:15 pm - 3:35 pm
Farshid Guilak (Washington University in St. Louis, USA)
"Targeted Genome Engineering to Develop Cell-Based Vaccines for Arthritis"
3:35 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
Matthew Veras (Western University, Canada)
"Loss of ENT1 Alters Cell Cycle Processes in the Annulus Fibrosus of the Intervertebral Disc"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Skeletal and Cartilage Pathology
Discussion Leader: Farshid Guilak (Washington University in St. Louis, USA)
5:30 pm - 5:40 pm
Anusha Ratneswaran (University of Western Ontario, Canada)
"Differences in Osteoarthritis Pathogenesis Between C57/B6 and CD1 Mice"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Jason Klein (University of Washington, USA)
"Characterizing Genetic Risk Factors for Osteoarthritis Through CRISPR/Cas9-Mediated Saturation Genome Editing of the GDF5 5' UTR"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Adrianne Stone (Baylor College of Medicine, USA)
"Combinatorial Gene Therapy of PRG4 and IL1Ra Is Protective of Cartilage Volume and Surface Area Compared to Monotherapy in a Murine Post-Traumatic Model of Osteoarthritis"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Mark Kim (University of Western Ontario, Canada)
"Characterization of the Mechano-Response of Annulus Fibrosus Cells to Cyclic Tensile Strain"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Marie Wehenkel (St. Jude Children's Research Hospital, USA)
"Investigating the Contributions of the Immune System to the Development of Cartilage Tumors"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Mateusz Aleksander Kudelko (The University of Hong Kong, Hong Kong SAR China)
"Proteomic Landscape of Murine Intervertebral Disc Reveals Mechanisms Involved in Homeostasis and Disc Structure Maintenance"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Andreas Finnøy (Norwegian University of Science and Technology (NTNU), Norway)
"What Can We Learn About Articular Cartilage Postnatal Maturation Using Second-Harmonic Generation Microscopy?"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Keynote Session: Stem-Cell Based Approaches for Cartilage Repair / Cartilage Development and Regeneration
Discussion Leader: Marina Feigenson (Harvard School of Dental Medicine, USA)
9:00 am - 9:20 am
April Craft (Boston Children's Hospital, USA)
"Cartilage from Embryonic Stem Cells: We All Gotta Start Somewhere"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Steven Woods (University of Manchester, United Kingdom)
"MATN3 V194D Mutant Human iPSCs Display Premature Hypertrophy and ER Stress During Chondrocyte Differentiation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Cheng Wang (The University of Hong Kong, Hong Kong SAR China)
"Mechanistic Insights into ER Stress Induced Skeletal Defects Identify Therapeutic Opportunities"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Beth Gibson (University of Newcastle, United Kingdom)
"The Disease Mechanisms of Skeletal Dysplasia Caused by Two Novel Aggrecan Mutations"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Manuela Rodrigues (University of Sao Paulo, Brazil)
"Thyroid Hormone Locally Interacts with the Sympathetic Nervous System to Control Bone Linear Growth"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Eran Assaraf (Weizmann Institute of Science, Israel)
"The Role of Proprioception and Specific Muscle Activity Patterns in Hip Joint Development and Maturation"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Shiri Kult (Weizmann Institute of Science, Israel)
"Tendon-to-Bone Attachment Unit – Two Faced Tissue"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Cell Metabolism and Regulation
Discussion Leader: Blandine Poulet (University of Liverpool, United Kingdom)
1:30 pm - 1:40 pm
Margaret Man-Ger Sun (University of Western Ontario, Canada)
"Investigating the Role of the Retinoid X Receptor in Cartilage Development and Homeostasis"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
James Anderson (University of Liverpool, United Kingdom)
"Equine Synovial Fluid Metabolite Profiles in Septic and Non-Septic Joint Pathologies"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Julia Etich (University of Cologne, Germany)
"MicroRNAs: Posttranscriptional Modulators of Cellular and Extracellular Cartilage Compartments"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes