Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: A Young PI's Path in Cartilage Research / Developments in Spine and IVD Research
Discussion Leader: Edward Mertz (National Institute of Child Health and Human Development, NIH, USA)
3:45 pm - 4:05 pm
Qing-Jun Meng (University of Manchester, United Kingdom)
"Keeping Time in Cartilage: A Journey from a Clock Biologist to a Cartilage Enthusiast"
4:05 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Matthew Veras (Bone and Joint Institute, Western University, Canada)
"Transcriptional Profiling of the Murine Intervertebral Disc and Age-Associated Changes in the Nucleus Pulposus"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: A Seasoned PI's Perspective on Cartilage Research / Skeletal Development: Where It All Starts
Discussion Leader: Venkata Mantripragada (Cleveland Clinic, USA)
7:30 pm - 7:50 pm
Henry Kronenberg (Massachusetts General Hospital / Harvard Medical School, USA)
"A Personal Perspective on the Ever-Changing Cartilage Field"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Juliane Heilig (Cologne Center for Musculoskeletal Biomechanics, Medical Faculty, University of Cologne, Germany)
"The Loss of Collagen Type IX Causes Premature Ossification of the Murine Femoral Head"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Steve Stegen (KU Leuven, Belgium)
"Glutamine Metabolism Controls Chondrocyte Fate and Function During Bone Development"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Christopher Smith (University of Manchester, United Kingdom)
"SIRT1 Activation in ESC Derived Prechondrocytes Promotes Cartilage ECM Expression"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Rosanne Raftery (Boston Children's Hospital, USA)
"Unraveling the Molecular Mechanisms of Articular Chondrocyte Stability Using Human Pluripotent Stem Cells"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Sarah Rice (Newcastle University, United Kingdom)
"Osteoarthritis-Associated Epigenetic Effects Operate in Cartilage and Limb Tissues During Human Fetal Development"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Qiwen Li (West China School of Stomatology, Sichuan University, China)
"Defect of Mettl1/Wdr4-Mediated tRNA M7G Methylome Leads to Primordial Dwarfism"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cartilage and Bone Diseases: From Exotic to Everyday
Discussion Leader: Supinder Kour Bali (The University of Western Ontario, Canada)
9:00 am - 9:10 am
Francesca Beaton (University of Cambridge, United Kingdom)
"Using a Mouse Model of Osteochondral Injury to Understand Bone and Articular Cartilage Repair"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Amalie Engstrøm (Nordic Bioscience, Denmark)
"Long-Term Compressive Loading of Articular Cartilage Confers Anti-Catabolic Effects on Cytokine-Mediated Cartilage Degradation"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Patrick Seifer (Center for Biochemistry, University of Cologne, Germany)
"Role of Matrilin-3 T298M Mutation in the Development of Osteoarthritis"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Chantal Voskamp (Erasmus University Medical Center, The Netherlands)
"TNFa Pretreatment Increased the Chondrogenic Potential of Mesenchymal Stem Cells Under Inflamed Conditions"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Steven Woods (University of Manchester, United Kingdom)
"Using Patient Derived Induced Pluripotent Stem Cells to Model Multiple Epiphyseal Dysplasia"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Yihan Liao (Duke University, USA)
"The Role of Interleukin 6 in Osteoarthritis Associated Cartilage Catabolism and Pain"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Hongyuan Zhang (Duke University, USA)
"Intracellular Cholesterol Biosynthesis Plays a Role in Enchondroma and Chondrosarcoma Tumor Growth"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Léa Loisay (Imagine Institute, France)
"Pathological Features of Activating Fgfr3 Highlighted in the Hypochondroplasia Mouse Model"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Novel Approaches to Target Cartilage Disease: Expanding the Toolbox
Discussion Leader: Kelsey Collins (Washington University in St. Louis, USA)
1:30 pm - 1:40 pm
Anna Albiero (University of Cambridge, United Kingdom)
"DACT1 Can Play a Significant Role Balancing Chondrocyte and Mesenchymal Stromal Cell Survival Through the Tgfβ Family and Wnt Signalling Pathways"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Veronika Georgieva (Center for Biochemistry, University of Cologne, Germany)
"MIR-322: A Posttranscriptional Regulator of Cartilage-Mediated Bone Remodeling"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Paul Humphreys (University of Manchester, United Kingdom)
"Synthetic Photo Receptor Engineering for Optogenetic Control of TGFβ Signalling to Drive Chondrogenesis"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
Paola Occhetta (University Hospital of Basel, Switzerland)
"Hyper-Physiological Compression Triggers Osteoarthritic Features in a Cartilage-on-Chip Model"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes