| Sunday, July 25, 1999 | Welcome to Oxford and Introductory Lecture |
5:00-5:15: Welcome, Marie-Françoise Chesselet (UCLA, USA), Conference Chair
5:15-6:30: Introductory Keynote Lecture, Susan Greenfield (Oxford University, UK)
"From chemicals to consciousness: letting the public in on the brain"
6:45PM: Dinner
| Monday, July 26th | Addiction and sensitization: new perspectives |
Session Chair: Terry Robinson (University of Michigan, USA)
8:40: Introduction
8:45-9:25: Terry Robinson (University of Michigan, USA)
"On the inevitability of sensitization following exposure to psychomotor stimulant drugs"
9:25-10:05: Pierre Sokoloff (INSERM,France)
"The dopamine D3 receptor and drug addiction: a novel therapeutic approach"
10:05-10:20: Coffee Break
10:20-11:00: Nora Volkow (Brookhaven National Laboratory, USA)
"Drug reinforcement and addiction in the human brain: the role of dopamine"
11:00-12:00: General Discussion: Discussant: Ann Kelley (University of Wisconsin, USA)
12:00-12:30: Poster Bullets: Chair: Lisa Taylor (Rutgers University, USA)
12:45: Group photo
1:00: Lunch followed by free afternoon
4:00-6:00: Poster Session 1
6:00-7:15: Dinner
| Catecholamines and neurotoxicity: implications for Parkinson's Disease |
Session Chair: Marie-Françoise Chesselet (UCLA, USA)
7:30: Introduction
7:35-8:15: Patricia Sonsalla (The University of Medicine and Dentistry of New Jersey,USA)
"Role of vesicular function (VMAT2) in neurotoxicity produced by drugs or neurotoxins"
8:15-9:05: Karen O' Malley (Washington University Medical School, USA)
"Mechanisms of neuronal death in Parkinson's Disease"
9:05-9:50: General Discussion: Discussant: Patrik Brundin (Lund University, Sweden)
10:00: Specialized workshop #1: Dopamine/glutamate interactions in the striatum.
Moderator: Michael Levine (UCLA, USA) and other workshops organized by conference participants. Poster viewing will continue concurrently until midnight.
| July 27, 1999 | Transporters: new faces, new functions |
Session Chair: Randy Blakely (Vanderbilt University, USA)
8:40: Introduction
8:45-9:25: Jonathan Javitch (Columbia University, USA)
"Probing the structure and function of the dopamine transporter"
9:25-10:05: Edgar Schömig (University of Heidelberg, Germany)
"Non-neuronal catecholamine transporters"
10:05-10:20: Coffee Break
10:20-11:00: Aurelio Galli (The University of Texas Health Science Center at San Antonio, USA)
"Channel functions of dopamine and norepinephrine transporters"
11:00-12:00: General Discussion: Discussant: Bruno Giros (INSERM, France)
12:00-12:30: Poster Bullets
12:45: Lunch followed by free afternoon
2:00: The Informal Career Workshop: "An international experience: what to expect, how to make it successful? Perspective from 'hosts' and from 'visitors'"
4:00-6:00: Poster Session 2
6:00-7:15: Dinner
| New adrenergic therapeutics |
Session Chair: Nancy Zahniser (University of Colorado, USA)
7:30: Introduction
7:35-8:15: Donny Strosberg (CNRS,France)
"New agonists of the human beta3 adreno-receptor for treating obesity"
8:15-9:05: Mervyn Maze (Stanford University, USA)
"Alpha2 adrenergic drugs in anesthesia and antinociception"
9:05-9:50: General Discussion: Discussant: Nancy Zahniser (University of Colorado, USA)
10:00: Specialized workshop #2: Catecholamine amperometry: from whole animals to single channels. Moderator: Greg Gerhardt (University of Colorado, USA) and other workshops organized by conference participants. Poster viewing will continue concurrently until midnight.
| July 28, 1999 | Molecular mechanisms of catecholamine receptor regulation |
Session Chair: Jeff Benovic (Thomas Jefferson University, USA)
8:40: Introduction
8:45-9:25: Jeff Benovic (Thomas Jefferson University, USA)
"Role of GRKs and arrestins in receptor regulation"
9:25-10:05: Michel Bouvier (Université de Montréal, Canada)
"Structural and pharmacological regulation of receptors' constitutive activity"
10:05-10:20: Coffee Break
10:20-11:00: Mark von Zastrow (University of California, San Francisco, USA)
"Receptor internalization"
11:00-12:00: General Discussion: Discussant: Graeme Milligan (University of Glasgow. UK)
12:00-12:30: Poster Bullets
12:45: Lunch followed by free afternoon
4:00-6:00: Poster Session 3
6:00-7:15: Dinner
Roles of catecholamines in cognition and attention:
relevance to schizophrenia and other mental illness |
Session Chair: Patricia Goldman-Rakic (Yale, USA)
7:30: Introduction
7:35-8:15: Marianne Amalric (CNRS-MRS, France)
"Role of dopamine in the basal ganglia: beyond motor control possible involvement in cognitive functions"
8:15-9:05: Graham V. Williams (Yale University, USA)
"Dopamine receptor modulation of local circuits in working memory"
9:05-9:50: General Discussion:Discussant: Trevor Robbins (University of Cambridge, UK)
10:00: Specialized workshop #3: Receptor/transporter trafficking. Moderator: Nancy Zahniser (University of Colorado, USA) and other workshops organized by conference participants. Poster viewing will continue concurrently until midnight.
| July 29, 1999 | Molecular mechanisms of catecholaminergic neurons differentiation and survival |
Session Chair: Arnon Rosenthal (Genentech Inc., USA)
8:40: Introduction
8:45-9:25: Arnon Rosenthal (Genentech Inc., USA)
"Control of cell fate and survival in the vertebrate midbrain"
9:25-10:05: Kwang Soo Kim (Harvard University,USA)
"Molecular mechanisms controlling the neurotransmitter phenotypes of noradrenergic neurons"
10:05-10:20: Coffee Break
10:20-11:00: Steve Thomas (University of Pennsylvania, USA)
"Transmitter identity: what does it mean? A genetic switch from norepinephrine to dopamine in mice"
11:00-12:00: General Discussion: Discussant: Dona Chikaraishi (Duke University, USA)
12:00-12:30: Poster Bullets
12:45: Lunch followed by free afternoon
4:30: Business Meeting
5:00-6:15: Keynote Lecture: Patricia Goldman-Rakic (Yale Univeristy, USA)
"Compartmentalization of neurotransmitter actions on cortical circuitry and cognitive function"
6:30: Pre-dinner drinks
7:00: Banquet
Departure Friday morning.
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