SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Introductory Comments by GRC Site Staff / Welcome from Chairs Leslie Parise & Gilbert White (UNC-CH & BRI-WI) |
7:45 pm - 9:30 pm | BIOLOGICAL INSIGHTS FROM NEW TECHNOLOGIES APPLIED TO MEGAKARYOCYTES AND PLATELETS |
| Discussion Leader: Sanford Shattil (UCSD) |
7:45 pm - 8:10 pm | Willem Ouwehand (University of Cambridge / Wellcome Trust Sanger Institute, UK)
"Platelet genomics" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Jun Lu (Broad Inst./MIT)
"MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Benjamin Cravatt (Scripps)
"Chemical proteomics and its potential applications for platelet biology" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Refreshments |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MEGAKARYOCYTE CELL LINEAGES AND TRANSCRIPTIONAL REGULATION: INSIGHTS FROM OTHER HEMATOPOIETIC LINEAGE PATHWAYS |
| Discussion Leader: Mitchell Weiss (Penn) |
9:00 am - 9:25 am | John Crispino (Northwestern)
"Role of GATA2 in megakaryocyte proliferation and differentiation" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Ramesh Shivdasani (Harvard)
"NFE-2 gene expression" |
10:05 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Coffee Break / Group Photo |
11:00 am - 11:25 am | Gerd Blobel (Penn)
"Lessons in the role of NURD complex in megakaryopoiesis" |
11:25 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Thomas Mercher (Harvard)
"The role of notch in megakaryopoiesis" |
12:05 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PLATELET GRANULES: FORMATION, TRAFFICKING AND RELEASE |
| Discussion Leader: Joseph Italiano (Harvard) |
7:30 pm - 7:55 pm | Mickey Marks (Penn)
"Protein sorting to platelet granules and how it goes awry in Hermansky-Pudlak syndrome: Lessons from pigment cells and fibroblasts" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Brian Storrie (U Arkansas)
"Heterogeneity of platelet granule contents" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Beth Bouchard (UVM)
"Mechanisms regulating megakaryocytic endocytosis, modification and storage of factor V" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm | Social Time |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NEW INSIGHTS INTO MEGAKARYOCYTES AND PLATELET FROM NOVEL MOUSE MODELS |
| Discussion Leader: Amy Geddis (UCSD) |
9:00 am - 9:25 am | Diane Krause (Yale)
"Role of Mkl1 leukemia translocation protein in megakaryocyte development" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Bernhard Nieswandt (R. Virchow Ctr)
"STIM1 and calcium signaling" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Patrick André (Portola)
"Targeting Syk signaling in thrombosis" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Jamey Marth (UCSD)
"Ashwell receptor regulation of platelet homeostasis" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Short Talk: Nathalie Delesque (Sanofi-Aventis)
"shRNA-mediated knockdown of TGS18 in the hematopoietic compartment: A phenotypic comparison with knockout-mice" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TRANSLATIONAL HIGHLIGHTS: THROMBOPOIETIN AND THROMBOPOIETIN MIMETICS |
| Discussion Leader: Katya Ravid (Boston) |
7:30 pm - 7:55 pm | Wei Tong (Penn)
"Thrombopoietin Receptor Signaling in Hematopoietic Stem Cells" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Alan Lazarus (Canadian Blood Srv)
"Mechanisms of Action of IVIg in ITP" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | David Kuter (Boston)
"Clinical rationale for TPO mimetics and ITP" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm | Social Time |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NEW INSIGHTS INTO PLATELET SIGNALING PATHWAYS AND THEIR IMPACT ON THROMBOSIS |
| Discussion Leader: Robert Flaumenhaft (Harvard) |
9:00 am - 9:25 am | Ulhas Naik (U Delaware)
"JAM-A signaling in platelets" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Steve Watson (U Birmingham)
"Comparison of the mechanism of the initiation of platelet activation by GPVI and CLEC-2" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10.50 am | Coffee Break |
10:50 am - 11:30 am | Niamh Moran (DMMC-Ireland)
"Novel integrin binding proteins" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Donna Woulfe (Jefferson)
"GSK3 regulation of platelet function" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Short Talk: Laure Gilles (INSERM U790)
"MKL1/SRF complex is involved in proplatelet formation and megakaryocyte migration by regulation MYL9 (MLC2) and MMP9" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | HOT TOPICS |
| Discussion Leader: Mortimer Poncz (Penn) |
7:30 pm - 7:40 pm | Lawrence "Skip" Brass (Penn)
"A phosphorylated complex of spinophilin with RGS10 and RGS18 provides a time- and context-dependent brake on excessive platelet activation" |
7:40 pm - 7:50 pm | Discussion |
7:50 pm - 8:00 pm | Michele Lambert (Penn)
"Low Density Lipoprotein Receptor Related Protein-1 (LRP1) is Transiently Expressed During Megakaryopoiesis and is the Receptor by which Platelet Factor 4 Inhibits Megakaryocyte Development" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:20 pm | Patricia Maguire (UCD)
"Canonical Wnt signalling negatively regulates human platelet function" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Nicholas Pineault (Hema-QC)
"Long-term and large-field live cell imaging provide new unexpected insights into megakaryocyte development and reveal major fate differences between cord blood and bone marrow derived megakaryocytes" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:00 pm | Alastair Poole (Bristol)
"PKCalpha is a critical regulator of platelet function and thrombosis formation" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Daphne Thijssen-Timmer (Sanquin)
"The role of meisi in the megakaryocytopoiesis" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Social Time |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | THE ROLE OF PLATELETS IN INFLAMMATION |
| Discussion Leader: Lawrence "Skip" Brass (Penn) |
9:00 am - 9:25 am | Jane Freedman (Boston)
"Immunity, Inflammation, and Platelet-dependent Thrombosis" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Klaus Ley (LIAI)
"Platelet - Neutrophil aggregation" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Steffen Massberg (DHM - Germany)
"Trafficking of hematopoetic stem cells - role of platelets" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Denisa Wagner (Harvard)
"Inflammation, hemorrhage & thrombocytopenia" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Short Talk: Maria Anna Kowalska (Penn)
"A unitary model of how PF4 contributes to physiologic thrombosis and to the pathologic disorder of heparin-induced thrombocytopenia (HIT)" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KEYNOTE TALKS |
| Discussion Leader: Jerry Ware (U Arkansas) |
7:30 pm - 8:15 pm | David Bodine (NIH)
"Hematopoietic stem cells" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Mark Ginsberg (UCSD)
"New concepts in the regulation of platelet integrins" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm | Social Time |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |