Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Thrombopoiesis and Thrombosis: Now and Tomorrow |
| Discussion Leader: Debra Newman (Blood Center of Wisconsin, USA) |
7:40 pm - 8:20 pm | John Hartwig (Brigham and Women's Hospital, USA) "Twenty Five Years of Platelet Biology" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Shaun Jackson (Heart Research Institute, Australia) "New Pathways Regulating the Proinflammatory Function of Platelets" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Platelets Beyond Hemostasis |
| Discussion Leader: Sidney Whiteheart (University of Kentucky, USA) |
9:00 am - 9:30 am | Mark Kahn (University of Pennsylvania, USA) "Platelets and Lymphangiogenesis" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Sandra Pinho (Albert Einstein College of Medicine, USA) "Role of the Megakaryocytic Niche in Hematopoietic Stem Cell Maintenance" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | John Semple (St. Michael's Hospital, Canada) "Platelets and Immunity" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Simon Foote (Australian National University, Australia) "Platelets Act as Primitive Hunter-Killer Cells in Malarial Infections" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Blood Pharming: Making In Vitro Platelets |
| Discussion Leader: Mortimer Poncz (Perelman School of Medicine at the University of Pennsylvania, USA) |
6:00 pm - 6:25 pm | Marloes Tijssen (University of Cambridge, United Kingdom) "Novel Regulatory Mechanisms of Megakaryopoiesis and Their Role in the In Vitro Production of Platelets" |
6:25 pm - 6:40 pm | Discussion |
6:40 pm - 7:05 pm | Koji Eto (Kyoto University, Japan) "Platelet Production from Human Pluripotent Stem Cells In Vitro" |
7:05 pm - 7:20 pm | Discussion |
7:20 pm - 7:45 pm | Alessandra Balduini (Tufts University / University of Pavia, Italy) "Autocrine and Environmental Factors in Megakaryocyte Regulation" |
7:45 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Signals that Direct Megakaryocytes and Platelets |
| Discussion Leader: Steve Watson (Birmingham University, United Kingdom) |
9:00 am - 9:30 am | Wolfgang Bergmeier (University of North Carolina at Chapel Hill, USA) "Platelet Signaling and Vascular Integrity" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Bernhard Nieswandt (University Clinic of Wuerzburg, Germany) "Platelet Adhesion Mechanisms in Arterial Thrombosis and Stroke" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Ulhas Naik (Thomas Jefferson University, USA) "Novel Suppressor of Platelet Integrin Signaling" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Michael Holinstat (University of Michigan Medical School, USA) "Oxylipin Regulation of Platelet Signaling and Thrombosis" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Seeing Is Believing: Visualizing New Platelet and Megakaryocyte Biology |
| Discussion Leader: Laura Gutierrez (Sanquin Research and Landsteiner Laboratory, The Netherlands) |
6:00 pm - 6:25 pm | Steffen Massberg (LMU Klinikum of University of Munich, Germany) "In Vivo Imaging of Platelet Production" |
6:25 pm - 6:40 pm | Discussion |
6:40 pm - 7:05 pm | Harry Heijnen (University Medical Center Utrecht, The Netherlands) "Platelets on the Run: Membrane Dynamics Under Flow" |
7:05 pm - 7:20 pm | Discussion |
7:20 pm - 7:45 pm | Renhao Li (Emory University, USA) "Platelet Mechanosensing by Membrane Receptor Unfolding" |
7:45 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Platelet and Megakaryocyte Membrane Dynamics |
| Discussion Leader: Walter Kahr (University of Toronto, Canada) |
9:00 am - 9:30 am | Martyn Mahaut-Smith (University of Leicester, United Kingdom) "Regulation of the Surface Membrane Invagination Systems of the Megakaryocyte and Platelet" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Jonathan Gibbins (University of Reading, United Kingdom) "New Gaps in Our Understanding of Platelet Function Regulation" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Donna Woulfe (University of Delaware, USA) "TMEM16f and Microparticles in Thrombus Formation" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Marcos Malumbres (Spanish National Cancer Research Center, Spain) "Cell Cycle Control in Megakaryocytes" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Late-Breaking Topics |
| Discussion Leader: Robert Flaumenhaft (Beth Israel Deaconess Medical Center, USA) |
6:00 pm - 6:10 pm | Stefanie Novakowski (University of British Columbia, Canada) "Delivery of Exogenous RNA to Platelets by Nanoliposomes" |
6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:25 pm | Florian Gaertner (LMU Munich, Germany) "Single Cell Tracking Reveals Autonomous Locomotion as a Platelet Function Facilitating Thrombus Reorganization" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Julia Geddings (University of North Carolina, USA) "Tumor Microvesicles Enhance Thrombosis in a Platelet-Dependent Manner" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 6:55 pm | Harald Schulze (University Hospital Wuerzburg, Germany) "Glycoprotein VI Interactions with Collagen Type I Selectively Inhibit Proplatelet Formation" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Vivien Chen (Concord Hospital / ANZAC Research Institute, Australia) "A Novel Marker for Imaging Procoagulant Platelets In Vitro and In Vivo" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Ejaife Agbani (University of Bristol, United Kingdom) "4D Imaging Reveals Coordinated Membrane Ballooning and Procoagulant Spreading in Human Platelets" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:40 pm | Massiel Stolla (University of Rochester, USA) "P-Selectin Expression and Platelet Function Are Developmentally Regulated" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Xiuli Sim (Children's Hospital of Philadelphia, USA) "Identification of Two In Vitro Megakaryocyte Pools" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Megakaryocyte and Platelet-Associated Diseases |
| Discussion Leader: Marco Vitale (University of Parma, Italy) |
9:00 am - 9:30 am | Katya Ravid (Boston University, USA) "Lysyl Oxidase: A Newly Identified Modulator of Megakaryocyte-Induced Myelofibrosis and Thrombosis" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Heyu Ni (University of Toronto / Canadian Blood Services, Canada) "Immune-Mediated Thrombocytopenia: Molecular and Cellular Events Following Antibody Targeting GPIba and aIIbβ3 Integrin" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Thomas Diacovo (Columbia University, USA) "Exploiting the Kinetic Interplay Between GPIba-VWF Binding Interfaces to Regulate Hemostasis and Thrombosis" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Jessica Cardenas (The University of Texas Health Science Center, USA) "Inhibition of TACE-Mediated GPib Alpha Receptor Shedding for Hemorrhage Control Following Trauma" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Peter Newman (Blood Research Institute, BloodCenter of Wisconsin, USA) "Gene Editing iPS Cells with CRISPR to Create Antigenically Distinctive Megakaryocyte Progenitors" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Regulating the Trillion Platelets in Our Blood |
| Discussion Leader: Benjamin Kile (Walter and Eliza Hall Institute for Medical Research, Australia) |
6:00 pm - 6:35 pm | Emma Josefsson (Walter and Eliza Hall Institite of Medical Research, Australia) "Regulation of Megakaryocyte and Platelet Survival" |
6:35 pm - 7:00 pm | Discussion |
7:00 pm - 7:35 pm | Karin Hoffmeister (Brigham and Women's Hospital / Harvard Medical School, USA) "Novel Mechanisms of Platelet Homeostasis" |
7:35 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |