Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Fundamental Biology to Novel Therapies
7:40 pm - 8:20 pm
"The Evolving Roles of Platelets in Health and Disease"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"GPVI: From Accessory Physiological Role to Major Therapeutic Asset"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Platelet Signaling: Lipids, Granules and Membranes
9:00 am - 9:25 am
"Activation of Platelet Function Through Adhesion G Protein-Coupled Receptors"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Putting It All Together: Integrating the Platelet Signaling Network and the Hemostatic Response to Injury"
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
"12-HETrE Exerts Its Antithrombotic Effects Through the Prostacyclin Receptor"
10:30 am - 10:35 am
Discussion
10:35 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Platelet Ballooning: Transforming Cell Shape for Procoagulant Activity"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Class II PI3Ks in Platelet Membrane Structure and Function"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"AADACL1
Regulates Platelet Granule Secretion and Thrombosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Embryonic and Ontological Development of Megakaryocytes and Platelets
6:00 pm - 6:25 pm
"Exploring the Mechanism of Platelet Formation During Prenatal Life"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Insights into the Transition from Neonatal to Adult Megakaryopoiesis"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Single Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Haematopoietic Cells"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Developing Live Imaging Strategies to Analyze MEP Fate Decisions at the Single Cell Level"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Achilles' Heels: Identifying the Causes of Congenital Platelet Disorders
9:00 am - 9:25 am
"Inherited Thrombocytopenias: Bleeding and Much More"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"ETV6-Related Thrombocytopenia: Lessons from Humans and Animal Models"
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Programmed Cell Death of Platelets and Megakaryocytes in Wiscott-Aldrich Syndrome"
10:30 am - 10:35 am
Discussion
10:35 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Finding Novel Genes for Inherited Bleeding Disorders with Platelet Dysfunction"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Role of FLNA and DIAPH1 in Macrothrombocytopenia - From Functional Studies to Diagnosis or Vice-Versa ?"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Inherited Loss of the Arp2/3 Complex Component ARPC1B Results in Microthrombocytes and Predisposes to Inflammatory Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Backbone
of the Lineage: TPO and c-Mpl Signalling in Health and Disease
6:00 pm - 6:25 pm
"Expression and Roles of the Mpl Receptor in Health and Disease"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"New Insights into Thrombopoietin Receptor Activation"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Clinical Effects of TPO Agents Inform Disease Biology"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Endocytosis of the Thrombopoietin Receptor Mpl Regulates both Megakaryocyte and Erythroid Progenitors and Is Critical for Myelofibrosis Development"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Myeloproliferative Neoplasms and Acute Megakaryoblastic Leukemia
9:00 am - 9:25 am
"Mechanisms of Acute Megakaryoblastic Leukemia in Non-Down Syndrome Patients"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia"
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
"One Cell at a Time: A Single-Cell Approach to Exploring Normal and Malignant Megakaryopoiesis"
10:30 am - 10:35 am
Discussion
10:35 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Aberrant Megakaryopoiesis in the Myeloproliferative Neoplasms"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Activation of the Thrombopoietin Receptor by Mutant Calreticulin in CALR-Mutant Myeloproliferative Neoplasms"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Activation of JAK/STAT Signaling in Megakaryocytes Is Necessary and Sufficient for Myeloproliferation In Vivo "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Form and Function: Cytoskeletal Regulation in Megakaryocytes and Platelets
6:00 pm - 6:25 pm
"Role of Cytoskeleton-Regulatory Proteins in Platelet Production and Function"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Actomyosin, Key Player at Multiple Steps in Platelet Biogenesis"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Platelet Actin Organisation – Peeking Beyond the Diffraction Limit"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Water Channel Aquaporin-1 Regulates Platelets' Procoagulant Response and In Vivo Thrombus Formation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Platelets, Inflammation and Innate Immunity
9:00 am - 9:25 am
"Platelets and Innate Immunity: From Mechanism to Populations"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Platelets and Platelet-Derived Microparticles in Antibody-Mediated Inflammatory Responses"
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Platelet Desialylation: Novel Mechanism of Immune Tolerance"
10:30 am - 10:35 am
Discussion
10:35 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Inflammation-Induced Emergency Hematopoiesis"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"The Balance Between Inflammation and Thrombosis During Gram-Negative Infection"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Emperipolesis Is a Novel Cell-in-Cell Phenomenon that Mediates Transfer of Neutrophil Membrane to Megakaryocytes and Platelets"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Tumour Cells and Platelets: Une Affaire Compliquée
6:00 pm - 6:25 pm
"Signaling Roles of Platelets During Metastatic Seeding"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Emerging Role of Platelets in Adaptive Changes to Anti-Angiogenesis Therapy"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Platelets and Tumor Cells: Breaking the Cycle"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Inhibition of Platelet Activity by Pim Kinase Inhibitors. A Novel Mechanism of Regulation of Thromboxane A2 Receptor Signalling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure