Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Fundamental Biology to Novel Therapies
Discussion Leader: Leslie Parise (University of North Carolina at Chapel Hill, USA)
7:40 pm - 8:20 pm
John Crispino (Northwestern University, USA)
"Defective Megakaryopoiesis in the Myeloproliferative Neoplasms"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Karin Hoffmeister (Blood Research Institute, BloodCenter of Wisconsin, USA)
"Novel Insights into Glycans and Hematopoiesis"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Platelet Receptors
Discussion Leader: Xiaoping Du (University of Illinois at Chicago, USA)
9:00 am - 9:25 am
Paul Bray (University of Utah, USA)
"Genomic Mechanisms Regulating Platelet Receptors for Collagen and Thrombin Signaling"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Jing Yang (Bristol-Myers Squibb, USA)
"In Search of a Safe Path to Thrombosis Prevention: The Discovery of Orally Active Small Molecule PAR4 Antagonists"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Carsten Deppermann (University of Calgary, Canada)
"Kupffer Cells Clear Aged, Desialylated Platelets Through Collaboration Between Macrophage Galactose Lectin (MGL) and the Ashwell-Morell Receptor"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Renhao Li (Emory University, USA)
"GPIb-IX MSD Dynamics and/or Thrombocytopenia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Benjamin Kile (Monash University, Australia)
"Platelet Survival and Clearance In Vivo "
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Renata Grozovsky (Brigham and Women's Hospital, USA)
"Desialylation and Apoptosis Are Related Events Leading to Platelet Clearance"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Renhao Li (Emory University, USA) and Ilaria Canobbio (University of Pavia, Italy)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Redefining the Lineage: Effect of Environmental Factors on Megakaryocyte Development
Discussion Leader: Walter Kahr (University of Toronto, Canada)
7:30 pm - 7:55 pm
Nathalie Brouard (Établissement Français du Sang (EFS), France)
"The Cellular Microenvironment of Megakaryopoiesis During Development"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Alejo Rodriguez-Fraticelli (Boston Children's Hospital / Harvard University, USA)
"Clonal Stem Cell Heterogeneity and Megakaryocyte Bias in Native and Transplantation Hematopoiesis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
David Stegner (University of Würzburg, Germany)
"Advanced Imaging to Study Thrombopoiesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Amie Waller (University of Cambridge, United Kingdom)
"Thyroid Hormones Induce Acute Platelet Production via a THR-Independent Mechanism Through aVb3, a Novel Pathway of Thrombopoiesis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Engineering Advances in Platelet Production and Platelet-Based Drug Delivery
Discussion Leader: Cedric Ghevaert (University of Cambridge, United Kingdom)
9:00 am - 9:25 am
Koji Eto (Kyoto University, Japan)
"Platelet Generation from iPS Cells"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Alessandra Balduini (Tufts University, USA)
"New Approaches in 3D Bio-Modelling to Document Megakaryocyte Functional Regulation by Extracellular Matrix Structure and Composition"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Alexandra Mazharian (University of Birmingham, United Kingdom)
"TREM-Like Transcript-1: A Novel Non-Conventional Regulator of Platelet and Megakaryocyte Function"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Zhen Gu (University of California, Los Angeles, USA)
"Platelet-Delivered Immunotherapies"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Anirban Sen Gupta (Case Western Reserve University, USA)
"Bio-Inspired Functional Mimicry of Platelets for Hemostatic and Drug Delivery Nanomaterials"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Robert Campbell (University of Utah, USA)
"Human Megakaryocytes Possess Intrinsic Anti-Viral Immunity Through Regulated Induction of IFITM3"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Disruptions in the Bone Marrow Niche
Discussion Leader: Katya Ravid (Boston University, USA)
7:30 pm - 7:55 pm
Diane Krause (Yale University, USA)
"The Role of the Cell Cycle in Megakaryocyte Fate Decisions"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Harald Schulze (University Hospital Würzburg, Germany)
"New Findings in Bone Marrow Remodeling"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Yotis Senis (University of Birmingham, United Kingdom)
"G6b-B, Congenital Macrothrombocytopenia and Myelofibrosis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Pavel Davizon (University of Colorado, USA)
"scRNA-Seq Transcriptome Analysis of Native Megakaryocytes Identifies Significant Inflammatory, Metabolic and Mitochondrial Signatures Associated to Platelet Hyperreactivity in Aging and MPN"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Expanding the Horizon of Megakaryocyte and Platelet Biology
Discussion Leader: Lawrence Brass (University of Pennsylvania, USA)
9:00 am - 9:25 am
Florian Gaertner (Institute of Science and Technology Austria, Austria)
"Platelets on the Move: Boosters of Innate Immunity"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Kathleen Freson (KU Leuven, Belgium)
"Finding Genes in Genomes to Match with Platelet Disorders"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Sarah Beck (University of Würzburg, Germany)
"Soluble Glycoprotein V Is a Novel Antithrombotic Agent"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Mark Looney (University of California, San Francisco, USA)
"Platelet Biogenesis in the Lung Circulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Peter Nigrovic (Harvard Medical School, USA)
"Megakaryocytes as Immune Cells"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Frederik Denorme (Kulak Kortrijk Campus, KU Leuven, Belgium)
"The VWF-GPIb Interaction Mediates Thrombo-Inflammation in Experimental Stroke via Recruitment of Monocytes, Neutrophils and T-Cells to the Brain"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Platelet Signaling
Discussion Leader: A. Koneti Rao (Sol Sherry Thrombosis Research Center, Temple University, USA)
7:30 pm - 7:55 pm
Mark Ginsberg (University of California, San Diego, USA)
"Rap1 Effectors for Integrin Activation in Platelets and Leukocytes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Maria Lozano (University of Murcia, Spain)
"Inherited Platelet Disorders: Characterization of Novel Variants and Phenotypic Correction by Gene Therapy"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Sonia Severin (Délégation Régionale Occitanie Pyrénées, INSERM, France)
"Class II and III PI3Ks in Platelet Genesis, Thrombosis and Beyond"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Ni Cheng (University of Illinois at Chicago, USA)
"Blocking of Integrin-Ga13 Interaction in Platelets or Leukocytes Protects Mice from Death in Severe Sepsis"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Interplay Between the Megakaryocyte Lineage and Inflammation
Discussion Leader: Craig Morrell (Aab Cardiovascular Research Institute (CVRI), University of Rochester School of Medicine, USA)
9:00 am - 9:25 am
Andrew Murphy (Baker Heart and Diabetes Institute, Australia)
"Regulating Thrombopoiesis to Limit Vascular Disease in Diabetes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Kellie Machlus (Harvard Medical School, USA)
"Role of CCL5 in Megakaryocyte Development, Maturation and Survival"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Jianlin Qiao (Xuzhou Medical University, China)
"NLRP3 Regulates Platelet Integrin aIIbb3 Outside-in Signaling, Hemostasis and Arterial Thrombosis Through IL-1"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Lubica Rauova (Children's Hospital of Philadelphia / University of Pennsylvania, USA)
"Platelet-Neutrophil Interactions: Lessons from Heparin Induced Thrombocytopenia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Benoit Ho-Tin-Noe (Laboratory for Vascular Translational Science (INSERM U1148), France)
"Understanding the Duality of Platelets in Inflammation: What's at Stake?"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Imene Melki (Centre de Recherche du CHU de Québec (CHUL), Université Laval, Canada)
"FcgRIIA Exacerbates Disease Pathogenesis and Platelet Activation in Systemic Lupus Erythematosus"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Single Cell Approaches to Study Megakaryocytes and Platelets
Discussion Leader: Debra Newman (BloodCenter of Wisconsin, USA)
7:30 pm - 7:55 pm
Klaus Hahn (University of North Carolina at Chapel Hill, USA)
"Building Proteins to Peek and Poke at GTPase Circuits In Vivo "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Bethan Psaila (University of Oxford, United Kingdom)
"One Cell at at Time: Single Cell Approaches to Studying Normal and Malignant Megakaryopoiesis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Andrew Frelinger (Center for Platelet Research Studies, Boston Children's Hospital, Harvard Medical School, USA)
"Mass Cytometry for Platelet and Megakaryocyte Characterization and Functional Analysis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Shauna French (Brigham and Women's Hospital / Harvard Medical School, USA)
"High Content Analysis of Megakaryocytes and Proplatelet Production via Supervised Machine-Learning"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure