Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Fundamental Biology to Novel Therapies
7:40 pm - 8:20 pm
"Defective Megakaryopoiesis in the Myeloproliferative Neoplasms"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Novel Insights into Glycans and Hematopoiesis"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Genomic Mechanisms Regulating Platelet Receptors for Collagen and Thrombin Signaling"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"In Search of a Safe Path to Thrombosis Prevention: The Discovery of Orally Active Small Molecule PAR4 Antagonists"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Kupffer Cells Clear Aged, Desialylated Platelets Through Collaboration Between Macrophage Galactose Lectin (MGL) and the Ashwell-Morell Receptor"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"GPIb-IX MSD Dynamics and/or Thrombocytopenia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Platelet Survival and Clearance In Vivo "
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Desialylation and Apoptosis Are Related Events Leading to Platelet Clearance"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Redefining the Lineage: Effect of Environmental Factors on Megakaryocyte Development
7:30 pm - 7:55 pm
"The Cellular Microenvironment of Megakaryopoiesis During Development"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Clonal Stem Cell Heterogeneity and Megakaryocyte Bias in Native and Transplantation Hematopoiesis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Advanced Imaging to Study Thrombopoiesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Thyroid Hormones Induce Acute Platelet Production via a THR-Independent Mechanism Through aVb3, a Novel Pathway of Thrombopoiesis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Engineering Advances in Platelet Production and Platelet-Based Drug Delivery
9:00 am - 9:25 am
"Platelet Generation from iPS Cells"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"New Approaches in 3D Bio-Modelling to Document Megakaryocyte Functional Regulation by Extracellular Matrix Structure and Composition"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"TREM-Like Transcript-1: A Novel Non-Conventional Regulator of Platelet and Megakaryocyte Function"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Platelet-Delivered Immunotherapies"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Bio-Inspired Functional Mimicry of Platelets for Hemostatic and Drug Delivery Nanomaterials"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Human Megakaryocytes Possess Intrinsic Anti-Viral Immunity Through Regulated Induction of IFITM3"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Disruptions in the Bone Marrow Niche
7:30 pm - 7:55 pm
"The Role of the Cell Cycle in Megakaryocyte Fate Decisions"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"New Findings in Bone Marrow Remodeling"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"G6b-B, Congenital Macrothrombocytopenia and Myelofibrosis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"scRNA-Seq Transcriptome Analysis of Native Megakaryocytes Identifies Significant Inflammatory, Metabolic and Mitochondrial Signatures Associated to Platelet Hyperreactivity in Aging and MPN"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Expanding the Horizon of Megakaryocyte and Platelet Biology
9:00 am - 9:25 am
"Platelets on the Move: Boosters of Innate Immunity"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Finding Genes in Genomes to Match with Platelet Disorders"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Soluble Glycoprotein V Is a Novel Antithrombotic Agent"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Platelet Biogenesis in the Lung Circulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Megakaryocytes as Immune Cells"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"The VWF-GPIb Interaction Mediates Thrombo-Inflammation in Experimental Stroke via Recruitment of Monocytes, Neutrophils and T-Cells to the Brain"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Rap1 Effectors for Integrin Activation in Platelets and Leukocytes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Inherited Platelet Disorders: Characterization of Novel Variants and Phenotypic Correction by Gene Therapy"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Class II and III PI3Ks in Platelet Genesis, Thrombosis and Beyond"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Blocking of Integrin-Ga13 Interaction in Platelets or Leukocytes Protects Mice from Death in Severe Sepsis"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Interplay Between the Megakaryocyte Lineage and Inflammation
9:00 am - 9:25 am
"Regulating Thrombopoiesis to Limit Vascular Disease in Diabetes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Role of CCL5 in Megakaryocyte Development, Maturation and Survival"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"NLRP3 Regulates Platelet Integrin aIIbb3 Outside-in Signaling, Hemostasis and Arterial Thrombosis Through IL-1"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Platelet-Neutrophil Interactions: Lessons from Heparin Induced Thrombocytopenia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Understanding the Duality of Platelets in Inflammation: What's at Stake?"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"FcgRIIA Exacerbates Disease Pathogenesis and Platelet Activation in Systemic Lupus Erythematosus"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Single Cell Approaches to Study Megakaryocytes and Platelets
7:30 pm - 7:55 pm
"Building Proteins to Peek and Poke at GTPase Circuits In Vivo "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"One Cell at at Time: Single Cell Approaches to Studying Normal and Malignant Megakaryopoiesis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Mass Cytometry for Platelet and Megakaryocyte Characterization and Functional Analysis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"High Content Analysis of Megakaryocytes and Proplatelet Production via Supervised Machine-Learning"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure