| SATURDAY |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:40 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:40 pm - 4:30 pm | Introduction to Megakaryocyte and Platelet Biology |
| Discussion Leaders: Jonathan Thon (Harvard University) and Milka Koupenova (University of Massachusetts) |
| 3:40 pm - 4:10 pm | Keynote Lecture: Jack Levin (University of California, San Francisco)
"Studies of the megakaryocyte/platelet lineage: A historical perspective" |
| 4:10 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Megakaryocyte and Platelet Biology I |
| Discussion Leaders: Milka Koupenova (University of Massachusetts) and Anthony D'Souza (Yale School of Medicine) |
| 7:30 pm - 7:45 pm | Ian Macaulay (Weatherall Institute of Molecular Medicine)
"Platelet-biased stem cells reside at the apex of the hematopoietic stem cell hierarchy |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Vishal Salunkhe (University College Dublin)
"The MEIS1 interactome in megakaryocytes reveals a role in cell cycle regulation" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Sabrina Zeddis (Sanquin Research)
"The RNA-binding protein ATAXIN-2 regulates megakaryocytic differentiation" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Justin Hamilton (Monash University)
"The Class II PI3K, PI3K-C2a, regulates platelet adhesion receptor function under shear and is important for the in vivo function of mouse platelets" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Martina Lundberg (Queen Mary University of London)
"Synergistic platelet inhibition by prostacyclin, nitric oxide and the P2Y12 inhibitor prasugrel" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Matthew Harper (University of Bristol)
"Coincident stimulation activates canonical transient receptor potential channels in platelets" |
| 9:25 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Megakaryocyte and Platelet Biology II |
| Discussion Leaders: Shinobu Matsuura (Boston University Medical School) and Bethany Kerr (Cleveland Clinic, Ohio) |
| 9:00 am - 9:15 am | Natalie Poulter (University of Birmingham)
"Dynamic imaging of actin nodules in platelet adhesion" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Robert Goggs (University of Bristol)
"Defining the role of RhoG in platelets" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Annachiara Mitrugno (Royal College of Surgeons in Ireland)
"Inhibition of Syk-PKC pathway in platelets impairs prostate cancer cells induced platelet secretion: Novel insights into platelet-cancer cell cross-talk" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Jessica Cedervall (Uppsala University)
"HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Kelly Metcalf Pate (Johns Hopkins University School of Medicine)
"Platelet activation and platelet-monocyte aggregate formation contribute to platelet decline during acute SIV infection in pigtailed macaques" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Amie Waller (University of Reading)
"The role of Staphylococcus aureus wall teichoic acid in potentiating activation of human platelets" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Career Development Round Table Discussion |
| Discussion Leaders: Leslie Parise (University of North Carolina at Chapel Hill), Katya Ravid (Boston University), Joseph Italiano (Harvard University), Steve Watson (University of Birmingham) and Robert Tressler (Cellerant Therapeutics, Inc.) |
| 1:30 pm - 1:45 pm | Career Talk: Leslie Parise (University of North Carolina at Chapel Hill)
"Balancing acts: towards an academic career in platelet biology" |
| 1:45 pm - 2:00 pm | Robert Tressler (Cellerant Therapeutics, Inc.)
"A pharmaceutical approach to platelet translational research" |
| 2:00 pm - 2:30 pm | Round Table Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
