Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: From Basic Biology to Novel Therapies
Discussion Leader: Natalie Poulter (University of Birmingham, United Kingdom)
3:15 pm - 3:45 pm
Martine Jandrot-Perrus (Laboratory for Vascular Translational Science (LVTS), Paris Diderot University, France)
"From Basic Biology to Novel Therapies"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Megakaryocyte and Platelet Signalling and
Development
Discussion Leaders: Alex Bye (University of Reading, United Kingdom) and Benjamin Tourdot (University of Michigan, USA)
5:30 pm - 5:45 pm
Vanessa Scanlon (Yale University, USA)
"Developing Live Imaging Strategies to Analyze MEP Fate Decisions at the Single Cell Level"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Veronica Palma Barqueros (Hospital General Universitario Morales Meseguer, Spain)
"Role of Immunoreceptor Tyrosine-Based Activation/Inhibition Motif (ITAM/ITIM)-Containing Receptors in Neonatal Platelet Reactivity"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Samantha Moore (University of Bristol, United Kingdom)
"Phosphorylation of GSK-3 Alpha Restrains GPVI-Mediated Platelet Function"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Chiara Pallini (College of Medical and Dental Sciences, University of Birmingham, United Kingdom)
"Investigating Collagen Receptor Organization and Signalling in Platelets Using Super Resolution Microscopy and Cluster Analysis"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Joanne Dunster (University of Reading, United Kingdom)
"The Importance of Regulation in GPVI Signal Transduction: A Systems Biology Approach"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Alex Slater (University of Nottingham, United Kingdom)
"Complement Receptor gC1qR Interaction with Coagulation Factor XII and Kininogen"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Megakaryocytes and Platelets in Health and
Disease
Discussion Leaders: Amanda Dalby (University of Cambridge, United Kingdom) and Marie-Blanche Onselaer (University of Birmingham, United Kingdom)
9:00 am - 9:15 am
Belinda Guo (University of Western Australia, Australia)
"Platelet Transcriptome Provides a Unique Insight on the Status of Bone Marrow Fibrosis in Patients with Myeloproliferative Neoplasms"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Marten Hansen (Sanquin, The Netherlands)
"GFI1B Regulates Megakaryocyte Development
Through LSD1 Interaction"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Abdullah Khan (University of Birmingham, United Kingdom)
"CRISPR-Cas9 Mediated Labelling of Genes Implicated in Thrombocytopenia for Super-Resolution Microscopy"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Andreas Wersall (University of Bristol, United Kingdom)
"Deletion of Ral GTPases in Mouse Platelets Reveals a Major Role in Regulation of a -Granule P-Selectin Exposure, but Not in the Release of a -Granule Content"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Amanda Unsworth (University of Reading, United Kingdom)
"Inhibition of Platelet Activity by Pim Kinase Inhibitors. A Novel Mechanism of Regulation of Thromboxane A2 Receptor Signalling"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Pierre Cunin (Brigham and Women's Hospital, USA)
"Emperipolesis Is a Novel Cell-in-Cell Phenomenon that Mediates Transfer of Neutrophil Membrane to Megakaryocytes and Platelets"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Careers in Academia and
Beyond
Discussion Leaders: Benjamin Kile (Walter and Eliza Hall Institute of Medical Research, Australia) and Wolfgang Bergmeier (University of North Carolina at Chapel Hill, USA)
1:30 pm - 1:45 pm
Nicola Mutch (University of Aberdeen, United Kingdom)
"Balancing Life with Haemostasis"
1:45 pm - 2:00 pm
Discussion
2:00 pm - 2:15 pm
Jonathan Thon (Brigham and Women's Hospital, USA)
"Combining Academia and Industry: My Experience"
2:15 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes