Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: From Stem Cells to Megakaryocyte and Platelet Production
Discussion Leader: Kirk Taylor (Imperial College London, United Kingdom)
3:45 pm - 4:15 pm
Cedric Ghevaert (University of Cambridge, United Kingdom)
"Producing Platelets In Vitro : The Challenges of MK Production and Platelet Release or Clinical Use: Numbers and Quality"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Megakaryocyte and Platelet Development and Signalling
Discussion Leaders: Carsten Deppermann (University of Calgary, Canada) and Shauna French (Brigham and Women's Hospital / Harvard Medical School, USA)
7:30 pm - 7:45 pm
Seema Bhatlekar (University of Utah, USA)
"Anti-Apoptotic BCL2L2 Promotes Megakaryocyte Expansion and In Vitro Platelet Production"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Dorsaf Ghalloussi (University of North Carolina at Chapel Hill, USA)
"Sustained Integrin aIIbĪ²3 Activation in Megakaryocytes Impairs Platelet Release in the Bone Marrow"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Tobias Heib (University Hospital Würzburg, Germany)
"Redundant and Non-Redundant Roles of RhoA and Cdc42 in Platelet Function and Biogenesis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Laura Menke (Queen Mary University of London, United Kingdom)
"Dihomo-Gamma-Linolenic Acid Alters the Proteomic Releasate Profile and Reduces Platelet Reactivity"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Tiffany Ni (University of Toronto, Canada)
"Two Birds, One Stone: Salvianolic Acids Inhibits Platelet Aggregation and Blood Coagulation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Alicia Eustes (University of Utah, USA)
"Signal Dependent Golgi Formation and De Novo Glycosylation in Human Platelets"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Megakaryocytes and Platelets in Health and Disease
Discussion Leaders: Pavel Davizon (University of Colorado, USA) and Frederik Denorme (Kulak Kortrijk Campus, KU Leuven, Belgium)
9:00 am - 9:15 am
Yacine Boulaftali (Laboratory for Vascular Translational Science, INSERM U1148, France)
"Critical Role of Platelets During Lung Fibrosis"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Aaron Petrey (Cleveland Clinic, USA)
"Platelet Hyaluronidase-2 Safeguards Against Inflammation by Regulating Endothelial Hyaluronan in Inflammatory Bowel Disease"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Patricia Davenport (Boston Children's Hospital, USA)
"Liberal Platelet Transfusions in the Setting of Neonatal Sepsis Increase Mortality and Modulate the Systemic Inflammatory Response"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Belinda Guo (University of Western Australia, Australia)
"Platelets as a Novel Indicator of Bone Marrow Fibrosis in Patients with Myeloproliferative Neoplasms"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Li Guo (University of Utah, USA)
"Platelets Directly Suppress CD8+ T Cells in Sepsis Through MHC Class I"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Ujjal Didar Singh Sekhon (Case Western Reserve University, USA)
"Nanomaterial Based Modular Integration of Pro-Coagulant Mechanisms on a Liposomal Template for Targeted Augmentation of Hemostasis"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Developing a Career in Academia: Insights and Perspectives
Discussion Leader: Amanda Unsworth (University of Reading, United Kingdom)
1:30 pm - 1:45 pm
Kellie Machlus (Harvard Medical School, USA)
"Developing a Career in Academia"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Zhen Gu (University of California, Los Angeles, USA)
"Career Insights and Perspectives"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:30 pm
Panel Discussion
A Career in Academia: Insights and Perspectives
Wolfgang Bergmeier (University of North Carolina at Chapel Hill, USA)
Elizabeth Gardiner (Australian National University, Australia)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes