Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Platelets and Inflammation
3:15 pm - 3:20 pm
Introduction by Discussion Leader
3:20 pm - 3:50 pm
"Targeting The Interaction of Platelet Adhesion Receptors with Damage-Associated Molecular Patterns in Thrombo-Inflammation"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Platelets in Health and Disease
5:30 pm - 5:40 pm
"Inflammatory Endothelial Cells Regulate Platelet Reactivity: Using Multi-Omics to Decipher Endothelial (Dys)Regulation of Platelets in Inflammatory Vessel-On-A-Chip-Models"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Platelet Derived Extracellular Vesicles Suppress Transfusion-Related Acute Lung Injury (TRALI)"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"P2Y12 Inhibition Suppresses Platelet Interferon-Associated Responses"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"Platelet Glycoprotein V Spatio-Temporally Controls Fibrin Formation"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"MiR-146a Has a Pleiotropic Role in Platelets Driving Metabolic Reprogramming and Tuning Reactivity and Thrombosis Threshold"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Ribosomal Biogenesis Inhibition Facilitates Megakaryocyte/Platelet-Biased Haematopoiesis"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Novel Mechanisms of Thrombopoietin Generation: The Critical Role of Kupffer Cells"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"A Novel Quantitative Flow Cytometry Approach in Determining Platelet Subpopulations and Quantifying Cell Surface Receptors"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Megakaryocytes in Health and Disease
9:00 am - 9:10 am
"CRISPR Optimization to Screen for Genes That Regulate Fate Specification of Primary Hematopoietic Progenitors"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Live-Monitoring of Human Megakaryocyte Function and Metabolism in a Silk-based Three-dimensional Bone Marrow Niche Model"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Vascularised Bone Marrow Organoids for the Study of Healthy and Diseased Megakaryocyte Biology"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Lung Megakaryocytes are Tissue Resident, Arise Independent of HSCs, and Contribute to Recovery in Low Platelet States"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"De-novo Hematopoiesis from the Fetal Lung"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Pim kinase: A Novel Regulator of Megakaryocyte and Platelet Production and Function"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Effects of the Shp2 Allosteric Inhibitor SHP099 on Megakaryopoiesis and Thrombopoiesis"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Loss of TCF3 Regulation in Megakaryocytes is Associated with Bone Marrow Fibrosis in Myeloproliferative Neoplasms"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Building a Career in Academia
1:30 pm - 2:30 pm
Panel Discussion
Mentorship Panel
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes