| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Metals and Cancer |
| Discussion Leader: Valeria Culotta (Johns Hopkins University) |
| 7:40 pm - 7:45 pm | Introductions by Discussion Leader |
| 7:45 pm - 8:15 pm | Thomas O’Halloran (Northwestern University)
"Metal Homeostasis Signatures in Development and Cancer" |
| 8:15 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:15 pm | Keynote Speaker: Stephen Lippard (M.I.T.)
"Understanding and Improving Platinum Anticancer Drugs" |
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Metals and Oxidative Stress |
| Discussion Leader: Sabeeha Merchant (UCLA) |
| 9:00 am - 9:25 am | Michael Daly (Uniform Services University of the Health Sciences, Bethesda, MD)
"Manganous Phosphate Proteome-Shields in Deinococcus radiodurans" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Eugen Urzica (UCLA)
"Transcriptome analysis of Chlamydomonas in different iron nutritional conditions" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break / Group Photo (10:15 am) |
| 10:30 am - 10:55 am | Vadim Gladyshev (U. Nebraska)
"Comparative genomics and evolution of metal utilization" |
| 10:55 am - 11:10 am | Discussion |
| 11:10 am - 11:35 am | Wayne Outten (U. South Carolina)
"The Suf pathway: Fe-S cluster biosynthesis at the convergence of iron starvation and oxidative stress" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Jim Imlay (U. Illinois, Urbana-Champaign)
"Oxidative stress and mononuclear metalloenzymes" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Metals and Neurodegeneration |
| Discussion Leader: Caryn Outten (U. S Carolina) |
| 7:30 pm - 7:55 pm | Gerd Multhaup (U. Berlin)
"Copper in Alzheimer’s disease" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Stephen Kaler (NICHD, NIH)
"Mechanisms of neurodegeneration in ATP7A copper transporter-related disorders" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Michael Aschner (Vanderbilt U)
"Mechanisms of manganese transport and neurotoxicity" |
| 9:15 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Biology of iron disorders |
| Discussion Leader: Jodie Babitt (Harvard Medical School) |
| 9:00 am - 9:15 am | Jodie Babitt overview of session |
| 9:15 am - 9:40 am | Randall Peterson (Harvard Medical School)
"In vivo discovery of small molecules that modify iron homeostasis" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:05 am | Jonathan Silberg (Rice U)
"In vivo fluorescent detection of 2Fe2S clusters coordinated by human glutaredoxin 2" |
| 10:05 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Andrew Dancis (U. Pennsylvania)
"Fe/S clusters in the mitochondrial intermembrane space" |
| 10:55 am - 11:10 am | Discussion |
| 11:10 am - 11:35 am | Jan Abkowitz (U. Washington)
"Heme trafficking, erythropoiesis and iron homeostasis" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Caroline Philpott (NIDDK, NIH)
"The PCBP family of iron chaperones" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Metals and immunity |
| Discussion Leader: David Giedroc (Indiana University) |
| 7:30 pm - 7:55 pm | Ivana De Domenico (U. Utah)
"The molecular basis of cellular iron export is linked to the transcriptional modulation of inflammation" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Iqbal Hamza (U. Maryland)
"To heme we bow: Transport and trafficking in eukaryotes" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | David Giedroc (Indiana University)
"Metal homeostasis and microbial pathogens" |
| 9:15 pm - 9:30 | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Monitoring metal in cells |
| Discussion Leader: David Eide (U. Wisconsin, Madison) |
| 9:00 am - 9:25 am | Jim Penner-Hahn (U. Michigan, Ann Arbor)
"XRF explorations of inorganic physiology" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Elisa Tomat (M.I.T.)
"Addressing Challenges of Mobile Zinc Detection in Biology Using Fluorescent Sensors" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Amy Palmer (U. Colorado, Bolder)
"Genetically targeted zinc sensors for monitoring the spatial distributions of zinc in live cells" |
| 10:55 am - 11:10 am | Discussion |
| 11:10 am - 11:35 am | Christoph Fahrni (Georgia Institute of Technology)
"Dynamic imaging of zinc by two-photon and x-ray fluorescence microscopy" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Chris Chang (U. California, Berkeley)
"Molecular Imaging Approaches to Understanding Copper Biology in the Brain" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Metal ion selectivity in cells |
| Discussion Leader: Megan McEvoy (U. Arizona) |
| 7:30 pm - 7:55 pm | Nigel Robinson (Newcastle University, UK)
"Protein-folding location determines whether Mn or Cu binds to
structurally similar proteins" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Jaekwon Lee (U. Nebrasksa)
"Cadmium-transporting P-type ATPase in yeast" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Barry Rosen (Florida International University)
"Evolution of metal(loid) binding sites in transcriptional repressors" |
| 9:15 pm - 9:30 | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Metal co-factor biogenesis | |
| Discussion Leader: Andrew Dancis (U. Pennsylvania) |
| 9:00 am - 9:25 am | William Walden (U. Illinois, Urbana-Champaign)
"Cytosolic FeS cluster biogenesis: Mechanisms and link to cellular iron
regulation" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Forian Bittner (Technische U. Braunschweig)
"The mitochondrial ABC transporter ATM3 as crosspoint between extramitochondrial iron-sulfur cluster assembly and molybdenum cofactor biosynthesis" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Dennis Dean (Virginia Tech U)
"In vivo analysis of Fe-S protein maturation" |
| 10:55 am - 11:10 am | Discussion |
| 11:10 am - 11:35 am | Simone Ciofi (U. Florence)
"Interplay between cysteine redox chemistry and metal binding in the
assembly of cytochrome c oxidase" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Janneke Balk (Cambridge University, UK)
"The role of mitochondrial ABC transporters in metal cofactor
biosynthesis" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Metal Metabolism and Development |
| Discussion Leader: Walter Schaffner (U. Zurich) |
| 7:30 pm - 7:40 pm | Introductions by Discussion Leader |
| 7:40 pm - 8:10 pm | Jerry Kaplan (U. Utah)
"The origin and function of serum ferritin" |
| 8:10 pm - 8:25 pm | Discussion |
| 8:25 pm - 9:15 pm | Keynote Speaker: Dennis Thiele (Duke University)
"Cellular and Systemic Regulation of Copper Absorption in Mammals" |
| 9:15 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
