Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Metal Homeostasis in Development and Disease
Discussion Leader: Roland Lill (Philipps-Universitaet Marburg, Germany)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Svetlana Lutsenko (Johns Hopkins University, USA)
"The Role of Copper Homeostasis in Lipid Metabolism"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Ralf Mendel (Braunschweig University of Technology, Germany)
"Molybdenum Metabolism: Pathways, Atomic Structures, Diseases"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metals in Enzyme Function
Discussion Leader: David Giedroc (Indiana University, USA)
9:00 am - 9:25 am
Nigel Robinson (Durham University, United Kingdom)
"A Cellular Logic for Enzyme Metalation"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Daniel Kosman (State University of New York at Buffalo, USA)
"Multicopper Metallo-Oxidases in Cellular Iron and Copper Metabolism"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Clorissa Washington-Hughes (University of South Carolina, USA)
"A Direct Correlation Between Enterobactin Transport and Nickel Resistance in E. coli "
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
Selected from Poster Abstracts: Thomas Kehl-Fie (University of Illinois at Urbana-Champaign, USA)
"You Are What You Don't Eat: Bacterial Adaptation to Nutritional Immunity"
10:35 am - 10:40 am
Discussion
10:40 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Vishal Gohil (Texas A&M University, USA)
"New Insights into Mitochondrial Copper Delivery to Cytochrome c Oxidase"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Sabeeha Merchant (University of California, Los Angeles, USA)
"Dynamic Metal Storage in Intracellular Organelles"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Kevin Waldron (Newcastle University, United Kingdom)
"Evolutionarily-Driven Cambialism in a Key Metalloenzyme Important During Staphylococcal Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structural Basis of Metalloprotein Function
Discussion Leader: Amy Rosenzweig (Northwestern University, USA)
7:30 pm - 7:55 pm
Amie Boal (Pennsylvania State University, USA)
"Metallocofactor Assembly in a Novel Manganese-Dependent Class I Ribonucleotide Reductase"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Hans Christensen (Technical University of Denmark, Denmark)
"The Structure of Dopamine β-Hydroxylase: The Cu Enzyme that Converts Dopamine to Norepinephrine"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Oriana Fisher (Northwestern University, USA)
"Characterization of a Unique Copper-Binding Protein from Methanotrophs"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Richard Ortega (Centre National de la Recherche Scientifique (CNRS), France)
"Imaging Bio-Metals in Neurons with X-Ray Nanobeams"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Metal Homeostasis
Discussion Leader: David Eide (University of Wisconsin-Madison, USA)
9:00 am - 9:25 am
Mitchell Knutson (University of Florida, USA)
"ZIP14 and ZIP8: Novel Players in Manganese Transport and Homeostasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Somshuvra Mukhopadhyay (The University of Texas at Austin, USA)
"Unexpected Hypothyroidism in Mice Lacking the Manganese Efflux Transporter SLC30A10"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Tom Bartnikas (Brown University, USA)
"Mechanisms of Mammalian Metal Excretion"
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
Selected from Poster Abstracts: Ciro Cubillas (Washington University in St. Louis, USA)
"A Genomic Analysis of Zinc-Regulated Transcription in Caenorhabditis elegans "
10:35 am - 10:40 am
Discussion
10:40 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Frederic Barras (Aix Marseille University / CNRS, France)
"Antibiotics and Metals: New Facts to an Old Story"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Ute Kraemer (Ruhr University Bochum, Germany)
"An Integrated Analysis of Metal Hyperaccumulation in Arabidopsis halleri "
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Caiyong Chen (Zhejiang University, China)
"TNGO-2 Regulates Cellular Heme Homeostasis in Metazoa"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metal Sensing and Dynamics
Discussion Leader: Daniela Buccella (New York University, USA)
7:30 pm - 7:55 pm
Ankona Datta (Tata Institute of Fundamental Research, India)
"Balancing Selectivity and Cellular Localization: Toward Optimal Sensors for Tracking Mn(II)"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Amit Reddi (Georgia Institute of Technology, USA)
"Heme Gazing: Probing Heme Trafficking, Signaling, and Dynamics with Fluorescent Sensors and Affinity Reagents"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
James Imlay (University of Illinois at Urbana-Champaign, USA)
"Molecular Explanations for the Toxicity of Oxygen"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Patricia Kiley (University of Wisconsin-Madison, USA)
"The Impact of Oxygen on Iron Homeostasis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metalloprotein Biogenesis and Signaling
Discussion Leader: Frederic Barras (Aix Marseille University / CNRS, France)
9:00 am - 9:25 am
Amanda Bird (The Ohio State University, USA)
"Metallation of the Pho8 Alkaline Phosphatase in Fission Yeast"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Simon Labbe (University of Sherbrooke, Canada)
"Spotlight on Schizosaccharomyces pombe Heme Acquisition Proteins"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Sven Freibert (Philipps-Universität Marburg, Germany)
"Structural and Functional Insights into Mitochondrial Fe/S Cluster Synthesis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
Selected from Poster Abstracts: Byung-Eun Kim (University of Maryland, USA)
"The Ctr1 Cu+ Transporter in Cardiovascular Function and Systemic Copper Signaling"
10:35 am - 10:40 am
Discussion
10:40 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Donita Brady (University of Pennsylvania, USA)
"Tracing Copper Utilization by Kinase Signal Transduction Pathways: Implications for Cancer Cell Metabolic Processes"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Silke Leimkuhler (University of Potsdam, Germany)
"The Connection of Molybdenum Cofactor Biosynthesis to Other Cellular Pathways at a Glance"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Kurt Warnhoff (Massachusetts General Hospital, USA)
"Interkingdom Transfer of Molybdenum Cofactor from E. coli to C. elegans "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Metals in Host-Pathogen Interactions
Discussion Leader: Elizabeth Nolan (Massachusetts Institute of Technology, USA)
7:30 pm - 7:55 pm
Pascal Arnoux (Institute of Biosciences and Biotechnology (BIAM), Aix-Marseille University, France)
"The Old Roots of Nicotianamine: Discovery of Analogs in Pathogenic Bacteria"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Christopher McDevitt (The University of Adelaide, Australia)
"The Antimicrobial Role of Zinc at the Host-Pathogen Interface"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Dennis Thiele (Duke University School of Medicine, USA)
"How Mammals and Fungal Pathogens Engage in a Tug-of-War over Copper"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Alejandro Vila (National University of Rosario, Argentina)
"Metallo-Beta-Lactamases: Periplasmic Raiders of the Lost Zinc"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metals in Physiology and Disease
Discussion Leader: Valeria Culotta (Johns Hopkins University, USA)
9:00 am - 9:25 am
Marla Berry (University of Hawaii at Manoa, USA)
"Selenium and Sex: Competition Between Brain and Testes for Se Results in Male-Specific Consequences in Mice and Men"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Elizabeth Leibold (University of Utah, USA)
"Iron Deficiency Caused by Loss of Iron-Regulatory Protein 2 Disrupts Mitochondrial Function and Comprises β-Cell Function"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Aslam Khan (University of Missouri, USA)
"A Role for Ceruloplasmin in Innate Immunity"
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
Selected from Poster Abstracts: Sarju Patel (National Institutes of Health, USA)
"A Novel Interaction Between Cytosolic Iron Chaperones PCBP1 and BolA2"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Stefano Rivella (Children's Hospital of Philadelphia, USA)
"The Dark Side of Iron in Erythropoiesis"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Daniel Kornitzer (Technion - Israel Institute of Technology, Israel)
"Structure of a Fungal Heme-Iron Acquisition Pathway"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Sargurunathan Subashchandrabose (Wake Forest School of Medicine, USA)
"Protective Role of Copper During Urinary Tract Infection"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Daniela Buccella (New York University, USA)
"Targeted Fluorescent Sensors Reveal Sub-Cellular Mg2+ Dynamics in Cell Death"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Metal Homeostasis from Worms to Mammals
Discussion Leader: Michael Petris (University of Missouri, USA)
7:30 pm - 8:10 pm
Vadim Gladyshev (Brigham and Women's Hospital, Harvard Medical School, USA)
"Two Hundred Years of Selenium Research"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 9:00 pm
Iqbal Hamza (University of Maryland, USA)
"Heme Trafficking: Lessons from Bloodless Worms"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
