Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Metals in the Omics Era
Discussion Leader: Vadim Gladyshev (Brigham and Women's Hospital / Harvard Medical School, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
David Eide (University of Wisconsin-Madison, USA)
"Meeting Your Quota: The Cellular Economy of Zinc"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Chu Wang (Peking University, China)
"Mining Metalloproteome by Chemical and Computational Proteomics"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Lucia Banci (University of Florence, Italy)
"Structural and Functional Characterization of Processes for Copper Transport and FeS Protein Biogenesis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metals at the Host-Pathogen Interface
Discussion Leader: Angela Wilks (University of Maryland, USA)
9:00 am - 9:25 am
Anirban Banerjee (National Institutes of Health, USA)
"In Vitro Reconstitution and Mechanistic Dissection of Iron Transport at the Host-Pathogen Interface for Legionella pneumophila "
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Montserrat Elias-Arnanz (University of Murcia, Spain)
"Vitamin B12 and Other Metal-Based Mechanisms in Bacterial Light Sensing and Signaling"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Duncan Wilson (University of Aberdeen, United Kingdom)
"Feeding on the Host: How Do Human Fungal Pathogens Acquire Essential Trace Metals During Infection?"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Paul Sigala (University of Utah School of Medicine, USA)
"Iron Utilization by Malaria Parasites"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Thomas Kehl-Fie (University of Illinois at Urbana-Champaign, USA)
"Bacterial Adaptation to Manganese Starvation: A Tale of Two Enzymes"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Aaron Smith (Duke University, USA)
"Transcriptional and Translational Reprogramming in Response to Copper Status in the Pathogenic Fungus Cryptococcus neoformans "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Amy Medlock (University of Georgia, USA) and Caryn Outten (University of South Carolina, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Metal Sensation and Homeostasis
Discussion Leader: Nigel Robinson (Durham University, United Kingdom)
6:00 pm - 6:25 pm
David Giedroc (Indiana University, USA)
"Molecular Mechanisms of Bacterial Metallostasis"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Sergi Puig (Instituto de Agroquimica y Tecnologia de Alimentos (IATA-CSIC), Spain)
"Regulatory and Metabolic Responses to Iron Deficiency"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Kerry Kornfeld (Washington University School of Medicine, USA)
"Zinc Sensing and Signaling in C. elegans "
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Selected from Poster Abstracts: Joseph Cotruvo, Jr. (Pennsylvania State University, USA)
"Selective Recognition and Utilization of Lanthanides in Biology"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am
Group Photo
9:00 am - 12:30 pm
Systemic Metal Sensing
Discussion Leader: Caroline Philpott (National Institutes of Health, USA)
9:00 am - 9:25 am
Yatrik Shah (University of Michigan, USA)
"A Novel Liver/Gut/Microbiota Axis Control Iron Homeostasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Jodie Babitt (Massachusetts General Hospital / Harvard Medical School, USA)
"Serum and Tissue Iron Sensing by the Liver"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Byung-Eun Kim (University of Maryland, USA)
"An Unexpected Role for Metal Transporters in Systemic Metabolism"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Martina Muckenthaler (Heidelberg University, Germany)
"Out-of-Balance: Pathophysiological Consequences of Iron Overload"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Kimberly Jett (University of Saskatchewan, Canada)
"Hepatic Bioenergetic Deficiency Induces a Novel Signal that Systemically Suppresses the Immune System"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Sivakumar Sambandan (Max Planck Institute for Biophysical Chemistry, Germany)
"Role of Zinc at Neuronal Nerve Terminals"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Rebecca Haeusler (Columbia University, USA)
"Bile Acid Regulation of Intestinal Manganese Transport"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Metal Partitioning
Discussion Leader: Sabeeha Merchant (University of California, Berkeley, USA)
6:00 pm - 6:25 pm
Adam Hughes (University of Utah, USA)
"Ironing-out the Connection Between Mitochondria and Lysosomes"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Paul Cobine (Auburn University, USA)
"Mitochondrial Copper Transporter Modulates Targets Inside and Outside of Mitochondria"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Amit Reddi (Georgia Institute of Technology, USA)
"Handling Heme: Probing the Mechanisms Underlying Heme Trafficking and Utilization"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Selected from Poster Abstracts: Caiyong Chen (Zhejiang University, China)
"Grab Regulates Endosomal Trafficking of The Transferrin Receptor in Developing Erythroblasts"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metallocofactors
Discussion Leader: Ralf Mendel (Braunschweig University of Technology, Germany)
9:00 am - 9:25 am
Guenter Schwarz (University of Cologne, Germany)
"Molybdenum Cofactor Synthesis and Enzymes in Mitochondria"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Gunhild Layer (University of Freiburg, Germany)
"Enzymology of Heme Biosynthesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Martin Warren (University of Kent, United Kingdom)
"The Special Relationship Between Cobalt and the Corrin Ring of Vitamin B12"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Amy Medlock (University of Georgia, USA)
"Unraveling the Complex(ity) of Heme Synthesis and Distribution"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Tessa Young (Durham University, United Kingdom)
"Understanding Cobalt Acquisition for Vitamin B12"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Satoshi Watanabe (Tohoku University, Japan)
"Structural Basis of Zinc-Dependent Protein Quality Control in the Early Secretory Pathway"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Marco Videira (ITQB-NOVA, Portugal)
"Control of Heme Biosynthesis and Acquisition in Staphylococcus aureus "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Paradigms in Metal Metabolism
Discussion Leader: Daniel Kosman (State University of New York at Buffalo, USA)
6:00 pm - 6:25 pm
Dennis Thiele (Duke University School of Medicine, USA)
"How Cells Import Copper and Cope with Copper Deficiency"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Peng Chen (Cornell University, USA)
"Understanding Bacterial Metal Defense via Single-Molecule/Cell Microscopy"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Amy Palmer (University of Colorado Boulder, USA)
"Zinc Regulation of the Mammalian Cell Cycle"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Selected from Poster Abstracts: Melissa Zastrow (University of Houston, USA)
"Uncovering Essential Metal Interactions in the Gut Microbiota: A Study on Lactobacillus plantarum and Zinc"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Metals in Physiology and Disease
Discussion Leader: Tom Bartnikas (Brown University, USA)
9:00 am - 9:25 am
Samira Lakhal-Littleton (University of Oxford, United Kingdom)
"Cardiovascular Iron Homeostasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Somshuvra Mukhopadhyay (The University of Texas at Austin, USA)
"Manganese Homeostasis and Induced-Parkinsonism: Insights from Studies of a Rare Genetic Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Herve Puy (Hôpitaux Universitaires Paris Nord Val de Seine, France)
"Lessons from Porphyrias: Disproportion of Iron and Heme"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Stephen Kaler (National Institutes of Health, USA)
"Mechanisms of ATP7A-Related Copper Transport Diseases"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Katherine Vest (University of Cincinnati, USA)
"Post-Transcriptional Regulation of Atp7a mRNA in Skeletal Muscle Myoblasts"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Malay Haldar (University of Pennsylvania, USA)
"New Roles of Transcription Factor Spic in Inflammation and Iron Metabolism"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Malek El Muayed (Northwestern University School of Medicine, USA)
"Cadmium Accumulation in Insulin Producing Beta Cells in the Pathophysiology of Type 2 Diabetes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Cellular Metal Compartmentalization and Regulation
Discussion Leader: Michael Petris (University of Missouri, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:45 pm
Mary Lou Guerinot (Dartmouth College, USA)
"Metal Dynamics: From the Soil to the Seed"
6:45 pm - 7:00 pm
Discussion
7:00 pm - 7:05 pm
Introduction by Discussion Leader
7:05 pm - 7:45 pm
Roland Lill (Philipps-Universität Marburg, Germany)
"Biogenesis of Iron-Sulfur Proteins in Eukaryotes: Mitochondria, Mitosomes, Mechanisms and Maladies"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure