Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Metal Nutrition from Plants to Humans
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"To Grow or to Defend? Iron at the Nexus of Root Response Programs"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Vitamin B12: From Biofortification to Industrial Biotechnology"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Uncovering Time-Dependent Iron-Related Phenotypes Using Dynamic Imaging and Computer Vision"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metals in Metabolic Disorders and Disease
9:00 am - 9:25 am
"Molecular and Cellular Mechanisms of Copper-Dependent Nutrient Signaling and Metabolism"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Role of Manganese in Inflammatory Bowel Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"How Studies of Wilsons Disease Helped Discover New Tissue Specific Functions of ATP7B"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"The Ins and Outs of Heme Transport"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Role of Hepatic Hypoxia Inducible Factors in Inherited Disorder of Manganese Excess due to Slc30a10 Deficiency"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Ironing Out the Details of Mitochondrial Translation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Environmental Impact of Metals
7:30 pm - 7:55 pm
"Marine Microbial Metaproteomics: Small Engines, Global Cycles"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"New Principles in Biological Recognition of Lanthanides"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"A Molecular Window into the Black Box of Environmental Trace Metal Speciation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Characterization of a Novel Methanogen Radical SAM/SPASM Domain Enzyme"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Metal Clusters, Cofactors and Catalysis
9:00 am - 9:25 am
"Glutathione at the Nexus of Iron and Redox Metabolism"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Molybdenum Cofactor Transport and Metabolism in the Nematode C. elegans "
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Metalloproteins in Chlorophyll Biosynthesis"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Zinc-Dependent In-Cell Kinetic Stability of Metallo-beta-Lactamases is a Key Evolutionary Trait"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Investigating the Biochemical Response of BTS-like Proteins"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structural Consequences of Turnover-Induced Homocitrate Loss in Nitrogenase"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Understanding Mis-metalation of Native Versus Heterologously Expressed Proteins"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metal Homeostasis in Cell Death and Aging
7:30 pm - 7:55 pm
"Design and Therapeutic Applications of a Small Molecule Inhibitor of Copper Transporting P-type ATPases"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Modulating Ferroptosis for Disease Prevention"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Mechanisms Regulating Copper-Dependent Cell Death"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Copper Homeostasis Regulates the Host Immune Response"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metal Trafficking, Storage and Regulation
9:00 am - 9:25 am
"From Zn Chaperones to Novel Heme Coordination: Genome Mining Provides the Spark"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Using the Circadian Clock to Uncover the Regulatory Role of Heme in Biology"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"New Insights into Iron Transport in Mycobacterium tuberculosis "
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Balancing Copper Economy and Luxury through a Conserved Signaling Pathway"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Cation Diffusion Facilitator Proteins Mediate Mn Tolerance in C. elegans "
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Uncovering Heme Binding Sites with a Bioinformatics Approach"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metals and Developmental Biology
7:30 pm - 7:55 pm
"Lysosome-Related Organelles Contain an Expansion Compartment that Mediates Zinc Transporter Delivery and Promotes Zinc Homeostasis in C. Elegans "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"From Fishtank to Bedside: Zebrafish to Model Inherited Manganese Transporter Defects"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"The Kynurenine Pathway in Systemic Zinc Regulation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Copper-Driven Signaling and Transcriptional Responses"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Metals at the Host Pathogen Interface
9:00 am - 9:25 am
"Metals, Secondary Metabolites, and the Variable Host Environment"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Bacterial and Host Metallophores in Infection Pathogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Developing Small Molecule Probes to Perturb Iron Homeostasis"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"sRNA-Controlled Iron Homeostasis in Staphylococci"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Maintenance of Organismal and Cellular Homeostasis by an Ancient Zinc Metallochaperone"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Bracing Bacillus for Copper Acquisition"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Imaging Metal Trafficking, Signaling and Reactivity
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
"Transition Metal Signaling and Metalloallostery in the Brain and Beyond"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Regulation of Cell Biology by Zinc"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure