Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Metal Nutrition from Plants to Humans
Discussion Leader: Mary Lou Guerinot (Dartmouth College, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Wolfgang Busch (Salk Institute for Biological Studies, United States)
"To Grow or to Defend? Iron at the Nexus of Root Response Programs"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Martin Warren (Quadram Institute Bioscience, United Kingdom)
"Vitamin B12: From Biofortification to Industrial Biotechnology"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
David Mendoza-Cozatl (University of Missouri, United States)
"Uncovering Time-Dependent Iron-Related Phenotypes Using Dynamic Imaging and Computer Vision"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metals in Metabolic Disorders and Disease
Discussion Leader: Valeria Culotta (Johns Hopkins University, United States)
9:00 am - 9:25 am
Donita Brady (University of Pennsylvania, United States)
"Molecular and Cellular Mechanisms of Copper-Dependent Nutrient Signaling and Metabolism"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Young Ah Seo (University of Michigan, United States)
"Role of Manganese in Inflammatory Bowel Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Svetlana Lutsenko (Johns Hopkins Medical Institutes, United States)
"How Studies of Wilsons Disease Helped Discover New Tissue Specific Functions of ATP7B"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Iqbal Hamza (University of Maryland School of Medicine, United States)
"The Ins and Outs of Heme Transport"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Milan Prajapati (Brown University, United States)
"Role of Hepatic Hypoxia Inducible Factors in Inherited Disorder of Manganese Excess due to Slc30a10 Deficiency"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Tslil Ast (The Weizmann Institute of Science, Israel)
"Ironing Out the Details of Mitochondrial Translation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Erin Connolly (Pennsylvania State University, United States) and Adelita Mendoza (Washington University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Environmental Impact of Metals
Discussion Leader: Mak Saito (Woods Hole Oceanographic Institution, United States)
7:30 pm - 7:55 pm
Jaclyn Saunders (University of Georgia, United States)
"Marine Microbial Metaproteomics: Small Engines, Global Cycles"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Joseph Cotruvo, Jr. (The Pennsylvania State University, United States)
"New Principles in Biological Recognition of Lanthanides"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Rene Boiteau (Oregon State University, United States)
"A Molecular Window into the Black Box of Environmental Trace Metal Speciation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Emily Dieter (Montana State University, United States)
"Characterization of a Novel Methanogen Radical SAM/SPASM Domain Enzyme"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Metal Clusters, Cofactors and Catalysis
Discussion Leader: Ralf R. Mendel (Braunschweig University of Technology, Germany)
9:00 am - 9:25 am
Caryn Outten (University of South Carolina, United States)
"Glutathione at the Nexus of Iron and Redox Metabolism"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Kurt Warnhoff (Sanford Research, United States)
"Molybdenum Cofactor Transport and Metabolism in the Nematode C. elegans "
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Jennifer Bridwell-Rabb (University of Michigan, United States)
"Metalloproteins in Chlorophyll Biosynthesis"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Alejandro Vila (IBR - University of Rosario, Argentina)
"Zinc-Dependent In-Cell Kinetic Stability of Metallo-beta-Lactamases is a Key Evolutionary Trait"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Jacob Pullin (John Innes Centre, United Kingdom)
"Investigating the Biochemical Response of BTS-like Proteins"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Rebeccah Warmack (California Institute of Technology, United States)
"Structural Consequences of Turnover-Induced Homocitrate Loss in Nitrogenase"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Sophie Clough (Durham University, United Kingdom)
"Understanding Mis-metalation of Native Versus Heterologously Expressed Proteins"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metal Homeostasis in Cell Death and Aging
Discussion Leader: Patricia Muller (Durham University, United Kingdom)
7:30 pm - 7:55 pm
Michael Petris (University of Missouri, United States)
"Design and Therapeutic Applications of a Small Molecule Inhibitor of Copper Transporting P-type ATPases"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Marcus Conrad (Helmholtz Munich, Germany)
"Modulating Ferroptosis for Disease Prevention"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Peter Tsvetkov (Broad Institute, United States)
"Mechanisms Regulating Copper-Dependent Cell Death"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Alexandra Mandarano (St. Jude Children's Research Hospital, United States)
"Copper Homeostasis Regulates the Host Immune Response"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metal Trafficking, Storage and Regulation
Discussion Leader: Caroline Philpott (NIH, United States)
9:00 am - 9:25 am
Crysten Blaby-Haas (Lawrence Berkeley National Laboratory, United States)
"From Zn Chaperones to Novel Heme Coordination: Genome Mining Provides the Spark"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Andrew Hudson (University of Leicester, United Kingdom)
"Using the Circadian Clock to Uncover the Regulatory Role of Heme in Biology"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Celia Goulding (University of California, Irvine, United States)
"New Insights into Iron Transport in Mycobacterium tuberculosis "
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Sabeeha Merchant (University of California, Berkeley, United States)
"Balancing Copper Economy and Luxury through a Conserved Signaling Pathway"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Ciro Cubillas (Washington University in Saint Louis - School of Medicine, United States)
"Cation Diffusion Facilitator Proteins Mediate Mn Tolerance in C. elegans "
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Noa Marson (University of Bristol, United Kingdom)
"Uncovering Heme Binding Sites with a Bioinformatics Approach"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metals and Developmental Biology
Discussion Leader: Thomas O'Halloran (Michigan State University, United States)
7:30 pm - 7:55 pm
Adelita Mendoza (Washington University, United States)
"Lysosome-Related Organelles Contain an Expansion Compartment that Mediates Zinc Transporter Delivery and Promotes Zinc Homeostasis in C. Elegans "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Karin Tuschl (University College London, United Kingdom)
"From Fishtank to Bedside: Zebrafish to Model Inherited Manganese Transporter Defects"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Fanis Missirlis (Cinvestav, Mexico)
"The Kynurenine Pathway in Systemic Zinc Regulation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Matthew Ross (University of Chicago, United States)
"Copper-Driven Signaling and Transcriptional Responses"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Metals at the Host Pathogen Interface
Discussion Leader: Clare Harding (University of Glasgow, United Kingdom)
9:00 am - 9:25 am
Elizabeth Nolan (Massachusetts Institute of Technology, United States)
"Metals, Secondary Metabolites, and the Variable Host Environment"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Jeffrey Henderson (Washington University School of Medicine, United States)
"Bacterial and Host Metallophores in Infection Pathogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Mario Rivera (Louisiana State University, United States)
"Developing Small Molecule Probes to Perturb Iron Homeostasis"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Philippe Bouloc (CNRS, Université Paris-Saclay, France)
"sRNA-Controlled Iron Homeostasis in Staphylococci"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Caitlin Murdoch (Vanderbilt University Medical Center, United States)
"Maintenance of Organismal and Cellular Homeostasis by an Ancient Zinc Metallochaperone"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Oriana Fisher (Lehigh University, United States)
"Bracing Bacillus for Copper Acquisition"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Imaging Metal Trafficking, Signaling and Reactivity
Discussion Leader: Amit Reddi (Georgia Institute of Technology, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
Christopher Chang (University of California, Berkeley, United States)
"Transition Metal Signaling and Metalloallostery in the Brain and Beyond"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Amy Palmer (University of Colorado Boulder, United States)
"Regulation of Cell Biology by Zinc"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure