Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Mechanisms of Intracellular Membrane Traffic |
| Discussion Leader: Claudia Bagni (University of Rome Tor Vergata, Italy / University of Lausanne, Switzerland) |
7:40 pm - 8:30 pm | Pietro De Camilli (Yale University, USA) "Membrane Contact Sites Within Neurons: An Inter-Organelle 'Connectome'" |
8:30 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Enqi He (Vrije University Amsterdam, The Netherlands) "Munc13-1 and Munc18-1 Prevent NSF-Dependent De-Priming of Synaptic Vesicles" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Shigeki Watanabe (Johns Hopkins University, USA) "Molecular Mechanisms of Ultrafast Endocytosis" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Trans-Synaptic Transfer in Development and Disease |
| Discussion Leader: Ryohei Yasuda (Max Planck Florida Institute for Neuroscience, USA) |
9:00 am - 9:20 am | Holly Cline (Scripps Research Institute, USA) "Trans-Cellular Protein Transfer in the CNS" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Larry Benowitz (Boston Children's Hospital / Harvard Medical School, USA) "Trans-Synaptic Zinc Signaling Regulates Cell Survival and Axon Regeneration After CNS Injury: The Optic Nerve Model" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Group Photo / Coffee Break |
10:30 am - 10:40 am | Kapil Ramachandran (Johns Hopkins Medicine, USA) "Identification and Characterization of a 20S Transmembrane Proteasome Complex that Generates a New Class of Extracellular Peptides to Modulate Neuronal Signaling" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Vivian Budnik (University of Massachusetts Medical School, USA) "Exosomes in Trans-Synaptic Signaling" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Erika Holzbaur (Perelman School of Medicine, University of Pennsylvania, USA) "Action at a Distance: Mechanisms Regulating Axonal Transport Initiation in the Distal Axon" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Chenghua Gu (Harvard Medical School, USA) "Transcytosis Regulation at the Blood-Brain Barrier" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Giordano Lippi (University of California, San Diego, USA) "MicroRNA-101 Constrains the Development of Neural Networks to Balance Excitation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Protein and RNA Trafficking in Dendrites and Axons |
| Discussion Leader: Erika Holzbaur (Perelman School of Medicine, University of Pennsylvania, USA) |
7:30 pm - 7:50 pm | Casper Hoogenraad (Utrecht University, The Netherlands) "Cytoskeletal Remodeling and Polarized Cargo Sorting" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Kelsey Martin (University of California, Los Angeles, USA) "Spatial Regulation of Gene Expression During Neuronal Plasticity" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Angelika Harbauer (Boston Children's Hospital, USA) "mRNA Transport and Local Protein Translation in Axons for Mitochondrial Clearance" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Gary Banker (Oregon Health and Science University, USA) "Identifying the Kinesins that Mediate Axonal and Dendritic Transport" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Amy Ghiretti (Perelman School of Medicine, University of Pennsylvania, USA) "Depolarization-Dependent Regulation of Distinct Transport and Microtubule Dynamic Functions of the Dendritic Kinesin KIF21B" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Assembly and Plasticity of Postsynaptic Structures |
| Discussion Leader: Yishi Jin (University of California, San Diego, USA) |
9:00 am - 9:20 am | Yimin Zou (University of California, San Diego, USA) "Signaling Mechanisms for Glutamatergic Synapse Development and Plasticity" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Daniel Choquet (CNRS, France) "Linking Glutamatergic Synapse Function and Nanoscale Dynamic Organization" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:40 am | Vidhya Rangaraju (Max Planck Institute for Brain Research, Germany) "Mitochondrial Compartments in Dendritic Local Protein Synthesis" |
10:40 am - 10:45 am | Discussion |
10:45 am - 10:55 am | Alexandros Kanellopoulos (VIB, KU Leuven, Belgium) "Reduced dCYFIP Affects Metabolism-Relevant Signaling Pathways Provoking Neuropsychiatric-Like Behavior" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Eunjoon Kim (Institute of Basic Science, KAIST, South Korea) "NMDA Receptor Dysfunctions in Autism Spectrum Disorders" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Peter Scheiffele (Biozentrum, University of Basel, Switzerland) "Alternative Splicing Programs for Synapse Specification" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Suzanne Zukin (Albert Einstein College of Medicine, USA) "The Memory Protein CPEB3 Coordinates AMPA Receptor mRNA Targeting to Dendrites and Transcription in Hippocampal Neurons of Fragile X Mice" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Mitchell Omar (Yale University, USA) "Late Developmental Changes in Dendrite Stability Are Controlled by Neuronal Laminin Alpha 5" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Assembly of Presynaptic Structures |
| Discussion Leader: Timothy Ryan (Weill Cornell Medicine, USA) |
7:30 pm - 7:50 pm | Kang Shen (Stanford University, USA) "Mechanisms of Neuronal Polarity in C. elegans" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Jiaxing Li (University of Michigan, USA) "A Kinesin Motor Regulates Synaptogenesis by Restraining a Nuclear Signaling Cascade" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Daniel Colon-Ramos (Yale University, USA) "Powering the Brain: Glycolytic Enzymes Localize to Synapses Under Energy Stress to Support Synaptic Function" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Matthew Pecot (Harvard Medical School, USA) "Selective Expression of ERM/dFezf Controls Layer Specificity in Analogous Cell Types Within the Drosophila Visual System" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Brock Grill (Scripps Florida, USA) "RPM-1 Regulates Axon Termination by Impacting Growth Cone Collapse and Microtubule Disassembly" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Signalling and Cell Growth in Neurons |
| Discussion Leader: Susumu Tomita (Yale School of Medicine, USA) |
9:00 am - 9:20 am | Dorothy Schafer (University of Massachusetts Medical School, USA) "Neural-Immune Mechanisms Regulating Activity-Dependent Refinement of Brain Circuits" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Michelle Monje (Stanford University, USA) "Myelin Plasticity in Health and Disease" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:40 am | Lesley Colgan (Max Planck Florida Institute for Neuroscience, USA) "PKCalpha Serves as a Coincident Detector of NMDAR and TrkB Activation to Induce Plasticity and Learning" |
10:40 am - 10:45 am | Discussion |
10:45 am - 10:55 am | Mark Dell'Acqua (University of Colorado School of Medicine, USA) "The ER Ca2+ Sensor STIM1 Directs L-Type Ca2+ Channel-Dependent Dendritic Spine Structural Plasticity and NFAT Signaling to the Nucleus" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Freda Miller (University of Toronto, Canada) "Translational Regulation of Cortical Neurogenesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Rosalind Segal (Harvard Medical School / Dana-Farber Cancer Institute, USA) "An RNA Regulon Coordinates Axonal Survival" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Tetsuya Takano (Graduate School of Medicine, Nagoya University, Japan) "Long-Range Inhibitory Signaling Ensures Single Axon formation" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Shiri Yaniv (Weizmann Institute of Science, Israel) "The Role of Actin in Axon Regrowth Following Pruning" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Function and Plasticity of the Synaptic Vesicle
Cycle |
| Discussion Leader: Matthijs Verhage (Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, The Netherlands) |
7:30 pm - 7:50 pm | Graeme Davis (University of California, San Francisco, USA) "Homeostatic Plasticity: Signaling from the Synaptic Cleft and Presynaptic Endoplasmic Reticulum" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Patrik Verstreken (VIB, KU Leuven, Belgium) "Protein Turnover at Synapses" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Ghazaleh Ashrafi (Weill Cornell Medicine, USA) "Activity-Driven Glut4 Mobilization at Nerve Terminals Is Critical for Energetic Support of Sustained Synaptic Transmission" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Matthijs Verhage (Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, The Netherlands) "Short Term Plasticity Mechanisms" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Kenneth Miller (Oklahoma Medical Research Foundation, USA) "Keeping Neuronal Cargoes on the Right Track: New Insights into Regulators of Axonal Transport" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Biology of Neuronal Degeneration and
Regeneration |
| Discussion Leader: Erik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA) |
9:00 am - 9:20 am | Aaron Diantonio (Washington University School of Medicine in St. Louis, USA) "The Role of MAP Kinase Signaling for SARM1-Dependent Axon Degeneration" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Marc Freeman (University of Massachusetts Medical School, USA) "Life and Death of the Axon" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:40 am | Ping Yue Pan (Icahn School of Medicine at Mount Sinai, USA) "Impaired Synaptic Vesicle Trafficking in LRRK2 Models of Parkinson's Disease" |
10:40 am - 10:45 am | Discussion |
10:45 am - 10:55 am | David Simon (The Rockefeller University, USA) "Control of Developmental Axon Degeneration by the Neuronal Cell Body" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Valeria Cavalli (Washington University School of Medicine in St. Louis, USA) "Activating Axon Regeneration Programs: From Histone Modifications to Lipid Synthesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Alison Lloyd (MRC Laboratory for Molecular Cell Biology, University College London, United Kingdom) "The Cellular Complexity of Peripheral Nerve Regeneration" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Francesca Bartolini (Columbia University, USA) "A Novel Role for Formin-Mediated Microtubule Hyperstabilization in Amyloid-β Synaptotoxicity" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Sean Sweeney (University of York, United Kingdom) "Regulation of Synaptic Growth by Rab8, IK2/TBK1 and AKT, Modifiers of Frontotemporal Dementia" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Keynote Session: Protein Aggregation and Neuropathology |
| Discussion Leader: Thomas Schwarz (Boston Children's Hospital, USA) |
5:30 pm - 5:50 pm | Frank Bradke (German Center for Neurodegenerative Diseases, Germany) "Transcriptome Analysis Identifies the Calcium Channel Subunit Alpha2delta2 as a Key Regulator of Axon Regeneration" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:10 pm | Qiaojin Lin (University of Cambridge, United Kingdom) "The Role of ALS-Associated Protein FUS in Local Protein Synthesis and Axon Maintenance" |
6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:25 pm | Tommy Lewis (Columbia University Medical Center, USA) "Molecular Mechanisms Underlying Polarized Mitochondria Structure and Function in Cortical Neurons" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 7:20 pm | Beth Stevens (Boston Children's Hospital, USA) "How Microglia Prune Specific Synapses in Health and Disease" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |