Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Cell Biology Revolution in Neuroscience
Discussion Leader: Matthijs Verhage (CNCR, The Netherlands)
7:40 pm - 8:25 pm
Reinhard Jahn (Max-Planck-Institute for Biophysical Chemistry, Germany)
"Exocytosis of Synaptic Vesicles: 25 Years of Molecular Research"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Thomas Sudhof (Stanford University, USA)
"Towards a Cell Biology of Synapse Formation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Organelle, Protein and RNA Trafficking
Discussion Leader: Jill Wildonger (University of Wisconsin-Madison, USA)
9:00 am - 9:25 am
Thomas Schwarz (Boston Children's Hospital, USA)
"Making, Breaking and Parking Neuronal Mitochondria"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Franck Polleux (Columbia University, USA)
"The ER-Mitochondria Interface Is Critical for Calcium Homeostasis and Synaptic Function in Mammalian Neurons"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Eva Karasmanis (Drexel University, USA)
"Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor-Cargo During Entry into Dendrites by a Microtubule-Associated Septin"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:25 am
Juan Bonifacino (National Institute of Child Health and Human Development, NIH, USA)
"Neuroaxonal Dystrophy and Autophagy Defects Caused by Failure of AP-4-Mediated Export of ATG9A from the TGN"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Subhojit Roy (University of Wisconsin-Madison, USA)
"Axonal Transport of Actin: A New Trafficking Paradigm"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Damien Jullie (University of California, San Francisco, USA)
"Opioid Receptors Reveal a Parallel Cycle of Regulated Presynaptic Membrane Trafficking"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Valeria Cavalli (Washington University in St. Louis, USA) and Erika Holzbaur (University of Pennsylvania, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transcriptional, Translational and Posttranslational Regulation
Discussion Leader: Matthew Dalva (Thomas Jefferson University, USA)
7:30 pm - 7:55 pm
Valeria Cavalli (Washington University in St. Louis, USA)
"Epigenetic Regulation of Axon Regeneration: The Role of Gene Repression"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Jens Hjerling Leffler (Karolinska Institutet, Sweden)
"Single-Cell Transcriptomics and the Study of the Brain"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Benita Turner-Bridger (University of Cambridge, United Kingdom)
"Single Molecule Analyses of Endogenous β-Actin mRNA Trafficking Reveal a Mechanism for Compartmentalised mRNA Localization in Axons"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Antonina Roll-Mecak (National Institutes of Health, USA)
"The Tubulin Code: How Cells Encode Specificity into Their Microtubule Networks"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synapse Dynamics and Function
Discussion Leader: Daniel Colón-Ramos (Yale University, USA)
9:00 am - 9:25 am
Volker Haucke (Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Germany)
"Mechanisms of Presynaptic Biogenesis and Function"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Erik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA)
"Shaping Membrane During Ultrafast Endocytosis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Noa Lipstein (Max Planck Institute of Experimental Medicine, Germany)
"Ca2+ -Dependent Control of the Synaptic Vesicle Replenishment Rate"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Timothy Ryan (Weill Cornell Medicine, USA)
"Metabolic Basis of Synaptic Performance"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Sai Krishnan (Universitätsklinikum Münster, Germany)
"Visualizing Compensatory Endocytosis in 'Xenapses', TIRF-Amenable Synapses"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
August Smit (Center for Neurogenomics and Cognitive Research, The Netherlands)
"SynGO: Evidence-Based Annotation of Synaptic Genes"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Grant Kusick (Johns Hopkins University School of Medicine, USA)
"Exocytosis Frozen in Time: Synchronous, Asynchronous and Multivesicular Release"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neurons in Context
Discussion Leader: Marc Hammarlund (Yale University, USA)
7:30 pm - 7:55 pm
Monica Driscoll (Rutgers University, USA)
"Trash Talk: C. elegans Neurons Throw out Garbage (Aggregates, Mitochondria)"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Thomas Kuner (Heidelberg University, Germany)
"Excitatory Neurogliomal Synapses Drive Brain Tumor Proliferation"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Peri Kurshan (Stanford University, USA)
"Gamma-Neurexin and Frizzled Mediate Parallel Synaptogenic Pathways Antagonized by Receptor Endocytosis"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Avital Rodal (Brandeis University, USA)
"Trafficking Mechanisms for Neuronal Extracellular Vesicle Cargoes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synaptic Alignment and Connectivity
Discussion Leader: Kang Shen (Stanford University, USA)
9:00 am - 9:25 am
Thomas Blanpied (University of Maryland School of Medicine, USA)
"Mechanism of Nanoscale Transsynaptic Alignment"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Yu-Ting Mao (Thomas Jefferson University, USA)
"Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
Pascal Kaeser (Harvard Medical School, USA)
"Assembly and Function of the Presynaptic Active Zone"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Joris de Wit (VIB Center for Brain and Disease Research, KU Leuven, Belgium)
"An Input-Specific Synaptic Organizing Complex Controls Mossy Fiber Synapse Development and Function"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Marinka Brouwer (Center for Neurogenomics and Cognitive Research / Vrije Universiteit Amsterdam, The Netherlands)
"SALM1 Controls Synapse Development by Regulating F-Actin/PIP2-Dependent Clustering of Neurexin"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Erin Barnhart (New York University, USA)
"Mitochondrial Dynamics and Dendritic Computation in the Drosophila Visual System"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Heather Broihier (Case Western Reserve University, USA)
"An Activity-Dependent Autocrine BMP Pathway Organizes Presynaptic Terminals at the Drosophila NMJ"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Homeostasis, Aggregation and Autophagy
Discussion Leader: Patrik Verstreken (VIB-KU Leuven Center for Brain and Disease Research, Belgium)
7:30 pm - 7:55 pm
Ai Yamamoto (Columbia University, USA)
"Oligodendroglial Autophagy"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Zu-Hang Sheng (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Energy Homeostasis in Health and Disease: Importance of Remobilizing Mitochondria in Distal Axons"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Andrea Stavoe (University of Pennsylvania, USA)
"Expression of WIPI2B Counteracts Age-Related Decline in Autophagosome Biogenesis in Neurons"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Ira Milosevic (European Neuroscience Institute / University Medical Center Göttingen, Germany)
"Regulation of Vesicle Acidification at the Neuronal Synapse"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Makoto Kinoshita (Nagoya University Graduate School of Science, Japan)
"An Activity-Regulated Septin Subunit Is Required for the Entry of Endoplasmic Reticulum into Dendritic Spines and Spatial Discrimination"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Biology of Neuronal Degeneration and Regeneration
Discussion Leader: Shelley Halpain (University of California, San Diego / Sanford Consortium for Regenerative Medicine, USA)
9:00 am - 9:25 am
Yishi Jin (University of California, San Diego, USA)
"Distinct Roles of Multiple RNA-Mediated Pathways in Axon Regeneration"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
William Hancock-Cerutti (Yale University, USA)
"VPS13A and VPS13C, Proteins Linked to Chorea-Acanthocytosis and Parkinson's, Are Lipid Transporters at Membrane Contact Sites"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
Charlotte Sumner (Johns Hopkins University School of Medicine, USA)
"Disrupted Motor Axonal Development in Motor Neuron Disease"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Xinnan Wang (Stanford University School of Medicine, USA)
"Mitochondrial Homeostasis in Parkinsonian Neurodegeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Meng-meng Fu (Stanford University, USA)
"The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ryan Insolera (University of Michigan, USA)
"Inhibition of Mitophagy Through the Loss of Ataxia Gene Vps13D Reveals Novel Neuron-Glia Coordination of Mitochondrial Destruction"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Cahir O'Kane (University of Cambridge, United Kingdom)
"Modeling a Dynamic Axonal ER Network by Hereditary Spastic Paraplegia Proteins"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: From Static Images to Imaging Dynamics in Living Neurons
Discussion Leader: Erika Holzbaur (University of Pennsylvania, USA)
5:30 pm - 6:15 pm
Lily Jan (University of California, San Francisco, USA)
"The Enigmatic TMEM16 Family"
6:15 pm - 6:30 pm
Discussion
6:30 pm - 7:15 pm
Jennifer Lippincott-Schwartz (Howard Hughes Medical Institute, USA)
"Spatial and Temporal Dynamics of ER-Organelle Contact Sites in Neurons"
7:15 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure