Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Neuronal Cell Biology and Diseases
Discussion Leader: Yishi Jin (University of California San Diego, United States)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Erika Holzbaur (University of Pennsylvania, United States)
"Organelle Quality Control in Neurons"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Matthew Rasband (Baylor College of Medicine, United States)
"The Functional Organization of Axons"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Controlling Neuronal Shape, Size and Repair
Discussion Leader: Binhai Zheng (University of California, San Diego, United States)
9:00 am - 9:20 am
Mike Fainzilber (Weizmann Institute of Science, Israel)
"RNA Localization for Neuronal Growth Regulation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Alyson Fournier (McGill University, Canada)
"Polypharmacological Approaches to Promoting Axon Regeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Oshri Avraham (Washington University School of Medicine, United States)
"Satellite Glial Cells Promote Axon Regeneration in Sensory Neurons"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:10 am
Oren Schuldiner (Weizmann Institute of Science, Israel)
"Mechanisms of Neuronal Remodeling"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Andrea Serio (The Francis Crick Institute & King's College London, United Kingdom)
"Shape Matters: Engineering Human Stem Cells Models to Understand the Relationship Between Form and Function in Neural Cells"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Alex Nechiporuk (Oregon Health & Science University, United States)
"Distinct Transcriptional Profile of Pioneer Neurons"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Marc Hammarlund (Yale University, United States)
"New Mechanisms in Axon Degeneration"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Rejji Kuruvilla (Johns Hopkins University, United States) and Cagla Eroglu (Duke University Medical Center, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene Regulation and Phase Transition in Health and Disease
Discussion Leader: Pietro De Camilli (Yale University, United States)
7:30 pm - 7:50 pm
Antonella Riccio (University College London, United Kingdom)
"RNA Metabolism in Developing Neurons"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Haiyang Yu (UT Southwestern Medical Center, United States)
"TDP-43 Multi-Phase Transition: from Cell Biology to Neurodegeneration"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Daehun Park (Yale University/HHMI, United States)
"Synaptic Vesicle Proteins and ATG9A Self-Organize in Distinct Vesicle Phases Within Synapsin Condensates"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Christian Hoffmann (German Center for Neurodegenerative Diseases (DZNE), Germany)
"Alpha-Synuclein: a Surfactant of Synaptic Condensates"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Lin Mei (Case Western Reserve University, United States)
"Membraneless Condensates by Phase Separation as a Platform for Neuromuscular Junction Formation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synaptic Transmission
Discussion Leader: Patrik Verstreken (VIB-KU Leuven Center for Brain and Disease Research, Belgium)
9:00 am - 9:20 am
Matthew Dalva (Thomas Jefferson University, United States)
"Synapse Formation and Plasticity: Roles for Biological-Sex and Synaptic Nanostructure"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Camin Dean (DZNE/Charite, Germany)
"Molecular Mechanisms of Forgetting"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Kamyra Edokpolor (Emory University, United States)
"Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2 Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Ege Kavalali (Vanderbilt University, United States)
"Unconventional Pathways Regulating Neurotransmission"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Peri Kurshan (Albert Einstein College of Medicine, United States)
"Intracellular Interactions Recruit Neurexin and Drive Presynaptic Stabilization in C. elegans"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
David Perrais (Interdisciplinary Institute of Neuroscience, France)
"Localization and Function of Endocytic Zones in Neuronal Dendrites in situ"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Matthijs Verhage (Center for Neurogenomics and Cognitive Research (CNCR), The Netherlands)
"Trafficking and Secretion of Neuropeptides and Neurotrophins in Human and Rodent CNS Neurons"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mitochondria and Cytoskeleton
Discussion Leader: Peri Kurshan (Albert Einstein College of Medicine, United States)
7:30 pm - 7:50 pm
Christian Gonzalez-Billault (University of Chile, Chile)
"Redox Biology Mechanisms Controls Axon Elongation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Shaul Yogev (Yale School of Medicine, United States)
"Expanding the Axonal Membrane-Associated Periodic Skeleton"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Rebecca Androwski (Rutgers University, United States)
"Cytoskeletal Remodeling and Nuclear Vesicle Release During Neuronal Extrusion Events"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Andrew Carter (University of Cambridge, United Kingdom)
"Dynein Transport in Neurons"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Vidhya Rangaraju (Max Planck Florida Institute for Neuroscience, United States)
"Spatial Organizers of Mitochondria in Locally Fueling Synaptic Plasticity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Jill Falk (Boston Children's Hospital/Harvard Medical School, United States)
"AMP Kinase Arrests Damaged Mitochondria"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Trafficking and Transport
Discussion Leader: Thomas Schwarz (Boston Children's Hospital, United States)
9:00 am - 9:20 am
Rejji Kuruvilla (Johns Hopkins University, United States)
"Neurotrophin Trafficking and Signaling Mechanisms in Neural Development"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Giampietro Schiavo (University College London, United Kingdom)
"Axonal Transport of Neurotrophic Factors and Their Therapeutic Applications"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Erica Dresselhaus (Brandeis University, United States)
"Biogenesis of Neuronal Extracellular Vesicles via the ESCRT Machinery"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Le Ma (Thomas Jefferson University, United States)
"Microtubule Regulation and Function at Axonal Branch Junctions"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Kelsie Eichel (Stanford University, United States)
"Receptor Endocytosis in the Axon Initial Segment Maintains Neuronal Polarity"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Jung Eun Shin (Dong-A Univeristy, South Korea)
"Regulation of Axonal Protein Synthesis During Axon Regeneration"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Bettina Winckler (University of Virginia, United States)
"Taking out the Trash: Transport of Late Endosomes in Dendrites"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Translation and Protein Homeostasis in Health and Disease
Discussion Leader: Monica Driscoll (Rutgers University, United States)
7:30 pm - 7:40 pm
Anna-Leigh Brown (University College London, United Kingdom)
"Common ALS/FTD Risk Variants in UNC13A Exacerbate its Cryptic Splicing and Loss Upon TDP-43 Mislocalization"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Yudong Gao (Duke University, United States)
"Mapping Endogenous Protein Interactomes in Autism Spectrum Disorder"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jeffery Twiss (University of South Carolina, United States)
"Spatial and Temporal Control of The Axonal Proteome"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Yishi Jin (University of California San Diego, United States)
"Protein Translation Regulation of Neuronal Activity"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Chun Han (Cornell University, United States)
"The Role of Phosphatidylserine Exposure in Neuronal Degeneration"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neuron-Glia Interaction and Communication
Discussion Leader: Cagla Eroglu (Duke University Medical Center, United States)
9:00 am - 9:20 am
Nicola Allen (Salk Institute for Biological Studies, United States)
"Astrocyte Regulation of Neuronal Synapses"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Aiman Saab (University of Zurich, Switzerland)
"Axon-Glia Crosstalk and Energy Homeostasis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Chinyere Agbaegbu Iweka (Stanford University, United States)
"Reduced Expression of Core Clock Protein, Bmal1, in Myeloid-Lineage Cells Impairs Microglia Function and Accelerates Cognitive Decline in Aged Mice"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Dilek Colak (Weill Cornell Medical College, United States)
"Astrocyte Pathology in ASD"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Ryan Baumert (Duke University, United States)
"Balancing of Neuronal Autophagy and Synaptic Growth by Huntingtin/a2d-1 Interaction"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Caterina Sanchini (Sapienza University, Italy)
"Microglia Reactivity Entails Microtubule Remodeling from Acentrosomal to Centrosomal Arrays"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Michael Granato (University of Pennsylvania, United States)
"A Glia Cell Derived Signaling Pathway Directs Target-Selective Peripheral Nerve Regeneration"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: New Technologies in Neuronal Cell Biology
Discussion Leader: Erika Holzbaur (University of Pennsylvania, United States)
5:30 pm - 5:40 pm
Closing Remarks
5:40 pm - 6:20 pm
Edward Boyden (Massachusetts Institute of Technology, Howard Hughes Medical Institute, United States)
"Optical Tools for Mapping and Controlling Complex Biological Systems"
6:20 pm - 6:35 pm
Discussion
6:35 pm - 7:15 pm
Xiaowei Zhuang (Harvard University, United States)
"Illuminating Neurobiology at the Nanoscale and Genome-Scale by Imaging"
7:15 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure