SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Cell Contact and Adhesion in Perspective |
| Discussion Leaders: Andrew Kowalczyk (Emory University) and Cara Gottardi (Northwestern University) |
7:40 pm - 8:10 pm | Pamela Cowin (New York University)
"Perspectives: 40 Years of Cell Contact and Adhesion"
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8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Kathleen Green (Northwestern University Feinberg School of Medicine)
"Desmosomes: Building specialized membrane scaffolds important for morphogenesis of complex tissues"
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8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | John Wallingford (HHMI, University of Texas at Austin)
"Planar cell polarity: From collective cell movement to human disease"
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9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Going with the Flow: Adhesion in Cardiovascular Biology |
| Discussion Leader: Elisabetta Dejana (IFOM, FIRC Institute of Molecular Oncology Foundation) |
9:00 am - 9:20 am | Elisabetta Dejana (IFOM, FIRC Institute of Molecular Oncology Foundation)
"Endothelial cell to cell junctions in vascular pathology"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Dietmar Vestweber (Max-Planck-Institute of Molecular Biomedicine)
"Mechanisms that regulate VE-cadherin and endothelial cell contacts"
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9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:50 am | Martin Schwartz (Yale University)
"VE-cadherin in mechanotransduction"
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10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Johan de Rooji (The Hubrecht Institute)
"Vinculin and associated proteins in Cadherin Mechanotransduction"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Mario Delmar (New York University)
"Plakophilin-2, connexin43 and the sodium channel complex: Partners in a heartbeat"
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11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Julie Gavard (CNRS/French National Center for Scientific Research)
"VE-cadherin endocytosis in vascular permeability"
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12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Cell Adhesion and Signaling in Morphogenesis |
| Discussion Leader: Jennifer Zallen (Sloan-Kettering Institute) |
5:30 pm - 5:50 pm | Jennifer Zallen (Sloan-Kettering Institute)
"Shaping the embryo: Cellular dynamics in development"
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5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Mark Peifer (University of North Carolina at Chapel Hill)
"The tumor Suppressor APC: A machine modulating Wnt signaling and genome stability"
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6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Stefano Piccolo (University of Padua School of Medicine)
"Mechanotransduction through YAP/TAZ: coupling cell adhesion to gene expression"
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6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:15 pm | Glenn Radice (Jefferson Medical College)
"Linking Cell Adhesion to Cardiac Regeneration"
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7:15 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Motility: Staying in Touch While on the Move |
| Discussion Leader: Al Reynolds (Vanderbilt University) |
9:00 am - 9:20 am | Al Reynolds (Vanderbilt University)
"Novel roles for p120 and Kaiso in colon cancer"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Masatoshi Takeichi (RIKEN Center for Developmental Biology)
"Contact-dependent promotion of cell motility by delta2-protocadherins"
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9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Sandrine Etienne-Mannville (Institut Pasteur - CNRS)
"Adherens junctions in collective cell migration"
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10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Gregory Longmore (Washington University School of Medicine)
"Epithelial Morphogenesis during Cancer Metastasis"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Rachel Hazan (Albert Einstein College of Medicine)
"N-cadherin signaling to invasion, survival and metastasis"
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11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Panos Z. Anastasiadis (Mayo Clinic)
"Polarity complexes and RhoA signaling in cell adhesion and directed cell migration"
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12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Making Connections and Forming Barriers |
| Discussion Leader: Carien Niessen (Center for Molecular Medicine Cologne) |
5:30 pm - 5:50 pm | Carien Niessen (Center for Molecular Medicine Cologne)
"Classical cadherins in the regulation of intercellular junctions: lessons learned from skin"
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5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | David Kelsell (Queen Mary University of London)
"Human skin disease and exome sequencing: insights within the desmosome"
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6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Alan Fanning (University of North Carolina at Chapel Hill)
"Role of Zonula Occludens-1 and -2 proteins in Epithelial Morphogenesis"
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6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:15 pm | Yusuke Toyama (National University of Singapore)
"Regulation of cell adhesion and mechanical forces during apoptosis in development"
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7:15 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Contact Regulation and Diversity |
| Discussion Leader: Frans Van Roy (University of Ghent) |
9:00 am - 9:20 am | Frans Van Roy (University of Ghent)
"Versatile functions of catenins in various cell types"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Eduard Batlle (Institute for Research in Biomedicine Barcelona)
"Formation of compartments in normal and tumor tissues by EphB/ephrinB signaling"
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9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Larry Shapiro (Columbia University)
"Structure and specificity of nectin family adhesion proteins"
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10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Sergey Troyanovsky (Northwestern University Feinberg School of Medicine)
"Actin and nectin in cadherin cluster formation and maintenance"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Roberto Cattaneo (Mayo Clinic)
"Viruses and nectins: ancient love, strategic exit"
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11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Scott W. Crawley (Vanderbilt University)
"Protocadherins form inter-microvillar adhesion links that are required for brush border assembly"
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12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Carrying the Load: Adhesion Receptors and Mechanotransduction |
| Discussion Leader: Andrés J. García (Georgia Institute of Technology) |
5:30 pm - 5:50 pm | Andrés J. García (Georgia Institute of Technology)
"Regulation of Cell Adhesive Forces"
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5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Sanjeevi Sivasankar (Iowa State University)
"Tuning the mechanics of cadherin adhesion"
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6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Jean-Paul Thiery (National University of Singapore)
"E-cadherin-mediated adhesion strengthening and mechanosensing"
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6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:15 pm | Noboru Ishiyama (Ontario Cancer Institute)
"Open and closed conformations of alpha-catenin control force-dependent modulation of cell-cell adhesion"
|
7:15 pm - 7:25 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Internal Affairs of Adhesion Receptors |
| Discussion Leader: Helen McNeill (Mount Sinai Hospital) |
9:00 am - 9:20 am | Helen McNeill (Mount Sinai Hospital)
"Fat cadherins in Hippo kinase regulation and PCP from flies to mice and men"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Pierre McCrea (University of Texas MD Anderson Cancer Center)
"Emerging nuclear roles of the larger catenin family"
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9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Vivian Tang (University of Illinois, Urbana-Champaign)
"Biochemical Dissection of Actin Regulation at the Adherens Junction" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | William Weis (Stanford University)
"Force transduction and conformational regulation of alpha-catenin"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Cara Gottardi (Northwestern University Feinberg School of Medicine)
"Cadherin/catenin phospho-regulation and signaling"
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11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Cécile Gauthier-Rouvière (CNRS - Macromolecular Biochemistry Research Center)
"Flotillin microdomains stabilize Cadherins at cell-cell junctions" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Dynamics of Adhesion Receptors at the Cell Cortex |
| Discussion Leader: Andrea McClatchey (MGH/Harvard Medical School) |
5:30 pm - 5:50 pm | Andrea McClatchey (MGH/Harvard Medical School)
"Organization of the Cell Cortex During Epithelial Morphogenesis"
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5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Dorit Hanein (Sanford Burnham Medical Research Institute)
"Viewing in 3D the molecular architecture of matrix adhesion machinery"
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6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Alpha Yap (University of Queensland)
"Mechanobiology, the active cortex and cadherin junctions"
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6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:15 pm | Roland Le Borgne (CNRS/Institute of Genetics and Development of Rennes)
"Dynamics of E-Cadherin dependent anchoring of cytokinesis ring and arrested cleavage furrows during Drosophila development"
|
7:15 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |