Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Molecular Basis of Intercellular Adhesion
Discussion Leader: John Wallingford (University of Texas at Austin, USA)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:40 pm
Masatoshi Takeichi (RIKEN Center for Biosystems Dynamics Research, Japan)
"Cell-Cell Adhesion Studies: History and Perspective"
8:40 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Regulation of Cell-Cell Junctions
Discussion Leader: Fanny Jaulin (Institut Gustave Roussy, France)
9:00 am - 9:25 am
Sandra Citi (University of Geneva, Switzerland)
"Mechanisms of Signalling at Apical Epithelial Junctions"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Kathleen Green (Northwestern University, USA)
"Surprising Functions of Desmosomal Cadherins in Development and Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Selected from Poster Abstracts: Junichi Ikenouchi (Kyushu University, Japan)
"Reciprocal Regulation of AJ and TJ During the Assembly of Apical Adhesion Complex"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Andrea McClatchey (Massachusetts General Hospital / Harvard Medical School, USA)
"Cytoskeletal Integration of Biochemical and Adhesive Cues"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Kris DeMali (Carver College of Medicine, University of Iowa, USA)
"Coupling Mechanotransduction and Cell Metabolism"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Shahana Chumki (University of Michigan, USA)
"Using Optogenetic Tools to Determine How Local Tight Junction Leaks and the Rho Flare Repair Mechanism Are Triggered"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Kris DeMali (Carver College of Medicine, University of Iowa, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanotransduction Through Adhesion Receptors
Discussion Leader: Deborah Leckband (University of Illinois at Urbana-Champaign, USA)
6:00 pm - 6:25 pm
Alex Dunn (Stanford University, USA)
"Force-Dependent Allosteric Regulation of Alpha-Catenin Binding to F-Actin by Vinculin"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
Selected from Poster Abstracts: Anna-Lena Cost (Max Planck Institute of Biochemistry, Germany)
"The Desmosome Is Mechanically Loaded in Response to Externally Applied Stress"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
Mary Lisa Manning (Syracuse University, USA)
"Modeling the Collective Behavior of Confluent Adhesive Cells"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
Selected from Poster Abstracts: Youmna Atieh (The University of Texas MD Anderson Cancer Center, USA)
"Dynamic Actomyosin Pulses Induce Tension Imbalance to Drive Epithelial Cell Extrusion"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Adhesion as a Regulatory Mechanism During Development
Discussion Leader: Mark Peifer (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:25 am
Yohanns Bellaiche (Genetics and Developmental Biology Unit (U934/UMR3215), Institut Curie, France)
"Dynamics of Proliferative Epithelial Tissue"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Suzanne Eaton (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
"Molecular and Mechanical Regulation of Tissue Morphogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Selected from Poster Abstracts: Kia Perez-Vale (University of North Carolina at Chapel Hill, USA)
"Defining the Role of the Adherens Junction-Actin Cytoskeletal Linker Canoe/Afadin in Epithelia Integrity and Morphogenesis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Thomas Lecuit (IBDM, Aix-Marseille Université / CNRS / College de France, France)
"Control and Self-Organization in Tissue Morphogenesis"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Ulrich Tepass (University of Toronto, Canada)
"Multi-Level Regulation of the Crumbs Polarity Protein Controls the Dynamics of Epithelial Cell Ingression"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Jeff Hardin (University of Wisconsin-Madison, USA)
"Mind the srGAP: Novel Roles for a Slit-Robo GAP During Epithelial Morphogenesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Quantitative Analysis of Adhesion Dynamics
Discussion Leader: Alex Dunn (Stanford University, USA)
6:00 pm - 6:25 pm
Daniel Fletcher (University of California, Berkeley, USA)
"Mind the Gap: Physical Segregation of Proteins at Cell-Cell Contacts"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
Selected from Poster Abstracts: Cara Gottardi (Northwestern University, USA)
"Cell-Cell Adhesion Regulation in Mitosis and Ploidy"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
Deborah Leckband (University of Illinois at Urbana-Champaign, USA)
"Cadherins and Growth Factor Receptors in Force Transduction"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
Selected from Poster Abstracts: Stephan Huveneers (Academic Medical Center / University of Amsterdam, The Netherlands)
"Sensing of Forces by Asymmetric Endothelial Junctions for Angiogenesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Adhesive Regulation of Cell Behavior
Discussion Leader: Andrea McClatchey (Massachusetts General Hospital / Harvard Medical School, USA)
9:00 am - 9:25 am
Xavier Trepat (Institute for Bioengineering of Catalonia (IBEC), Spain)
"Mechanobiology of Epithelial Growth and Folding"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Sara Wickstrom (University of Helsinki, Finland)
"Mechanisms of Nuclear Mechanoprotection and Mechanoadaptation"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Selected from Poster Abstracts: Rene-Marc Mege (Institut Jacques Monod / CNRS, France)
"Emergence of Single Cell Mechanical Behavior and Polarity Within Epithelial Monolayers Drives Collective Cell Migration"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Danijela Matic Vignjevic (Institut Curie, France)
"Epithelial Renewal in Gut Homeostasis"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Venkataramana Sidhaye (Johns Hopkins University, USA)
"Epithelial Function and Monolayer Integrity in Chronic Obstructive Pulmonary Disorder"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Roberto Cattaneo (Mayo Clinic , USA)
"Nectin-Elicited Cytoplasm Transfer: A Process Accounting for Infection of Neurons by Measles Virus"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Non-Canonical Roles of Adhesion Receptors
Discussion Leader: Sara Wickstrom (University of Helsinki, Finland)
6:00 pm - 6:25 pm
Fanny Jaulin (Institut Gustave Roussy, France)
"Upside Down Polarity"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
Selected from Poster Abstracts: Yarden Opatowsky (Bar Ilan University, Israel)
"Structural Principles in Robo Activation and Auto-Inhibition"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
Lucy O'Brien (Stanford University, USA)
"Collective Cell Dynamics of Organ Renewal"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
Tony Tsai (Harvard Medical School, USA)
"An Adhesion Code Enables Robust Pattern Formation in the Zebrafish Spinal Cord"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Adhesive Regulation of Cancer Cell Invasion and Metastasis
Discussion Leader: Kathleen Green (Northwestern University, USA)
9:00 am - 9:25 am
Patrick Derksen (UMC Utrecht, The Netherlands)
"Loss of Epithelial Cell Adhesion and Breast Cancer Dormancy"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Peter Friedl (Radboud University Nijmegen Medical Centre, The Netherlands)
"Multistep Fluidization of Multicellular Invasion"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Selected from Poster Abstracts: Veena Padmanaban (Johns Hopkins University School of Medicine, USA)
"E-cadherin Is an Invasion Suppressor, Survival Factor, and Metastasis Promoter in Multiple Models of Breast Cancer"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Alpha Yap (University of Queensland, Australia)
"Neighbourhood Watch by Cell-Cell Mechanotransduction"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Martin Schwartz (Yale School of Medicine, USA)
"Flow Signaling at Endothelial Cell-Cell Junctions"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Tiama Hamkins-Indik (University of California, Berkeley, USA)
"Affinity of ZO-1 to Actin Modulates Barrier Function"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Regulation of Morphogenesis by Adhesion
Discussion Leader: Alpha Yap (University of Queensland, Australia)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 7:00 pm
John Wallingford (University of Texas at Austin, USA)
"Planar Cell Polarity: From Cell Adhesion to Tissue Mechanics"
7:00 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
General Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
