Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Molecular Basis of Vascular Intercellular Adhesion
Discussion Leader: Mark Peifer (University of North Carolina at Chapel Hill, United States)
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:40 pm
Martin Schwartz (Yale School of Medicine, United States)
"Cell-Cell Junctions in Endothelial Fluid Shear Stress Mechanotransduction"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Jaap van Buul (University of Amsterdam, The Netherlands)
"How Leukocytes Cross the Endothelial Barrier: Spatiotemporal Endothelial Signals Control Extravasation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Insights into the Molecular Composition of Cell Contacts
Discussion Leader: Yulia Komarova (University of Illinois at Chicago, United States)
9:00 am - 9:30 am
Gregory Alushin (The Rockefeller University, United States)
"Visualizing Cellular Force-Sensing Through the Actin Cytoskeleton"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Rafael Garcia-Mata (University of Toledo, United States)
"SGEF, a RhoG Specific GEF, Regulates E-Cadherin Stability, Turnover and Transcription in Epithelial Cells"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Velia Fowler (University of Delaware, United States)
"A Short Isoform of Tensin1 is a Novel Regulator of Erythroblast Enucleation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Lindsay Case (MIT, United States)
"Protein Phase Separation Promotes Integrin Receptor Clustering and Downstream Signaling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Junior West (Johns Hopkins University School of Medicine, United States)
"The Tight Junction Inhibits Cancer Invasion and Metastasis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Alf Honigmann (Technical University Dresden, Germany)
"Role of ZO1 Membrane Condensation for Tight Junction Assembly"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Andrew Kowalczyk (Penn State University, United States) and Cara Gottardi (Northwestern University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Interactions at Desmosomes, Tight Junctions and Beyond
Discussion Leader: Carien Niessen (University of Cologne, Germany)
7:30 pm - 8:00 pm
Andrew Kowalczyk (Penn State University, United States)
"Reimagining the Desmosome as a Multi-Organelle Membrane Domain"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Mikio Furuse (National Institute for Physiological Sciences, Japan)
"Tricellular Junctions"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Alexa Mattheyses (University of Alabama at Birmingham, United States)
"Nanoscale Desmosome Architecture and Cell-Cell Adhesion"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Exploring Cell Interactions
Discussion Leader: Adam Kwiatkowski (University of Pittsburgh School of Medicine, United States)
9:00 am - 9:30 am
Ana Suncana Smith (FAU Erlangen Nürnberg Germany/ Ruder Boškovic Institute, Zagreb, Croatia, Germany)
"Physics of Cell Adhesion in the Regulation of Activation of Natural Killer Cells"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Ann Miller (University of Michigan, United States)
"Maintenance and Remodeling of Epithelial Cell-Cell Junctions During Cell Shape Changes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:35 am
Tony Tsai (Washington University in St. Louis, United States)
"The Adhesion Basis of Robust Spinal Cord Morphogenesis"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Group Photo / Coffee Break
11:10 am - 11:40 am
Tristan Driscoll (FAMU-FSU College of Engineering, United States)
"Stable and Dynamic Forces in Integrin Based Adhesions"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Zimei Bu (City College of New York, CUNY, United States)
"An Ensemble of Cadherin-Catenin-Vinculin Complex Employs Vinculin as the Major F-actin Binding Mode"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Alex Dunn (Stanford University, United States)
"Afadin and Zonula Occludens-1 form Tension-Responsive Linkages to Nectin and Junctional Adhesion Molecule-A"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Interactions as Integrators of Mechanical Signals
Discussion Leader: Tristan Driscoll (FAMU-FSU College of Engineering, United States)
7:30 pm - 8:00 pm
Alpha Yap (University of Queensland, Australia)
"Cell-Cell Recognition by Cadherin-Based Mechanotransduction."
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Benoit Ladoux ( CNRS Université Paris Cité, France)
"The Role of Mechanical Forces and Cell-Cell Adhesion in the Fate of Extruding Cells"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Jennifer Zallen (Sloan Kettering Institute, United States)
"Signals, Forces, and Cells: Decoding Tissue Morphogenesis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Interactions as Integrators of Cell Signaling
Discussion Leader: Cara Gottardi (Northwestern University, United States)
9:00 am - 9:30 am
Gaudenz Danuser (UT Southwestern Medical Center, United States)
"Proliferation Signaling from Pseudo-Adhesions"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Marcos Simoes-Costa (Harvard University, United States)
"Metabolic Control of Neural Crest Migration"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Stacey Ogden (St. Jude Children's Research Hospital, United States)
"Contributions of BOC and CDON Adhesion Receptors to Cytoneme Mediated Sonic Hedgehog Morphogen Deployment and Reception"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Junior West (Johns Hopkins University School of Medicine, United States)
"The Tight Junction Inhibits Cancer Invasion and Metastasis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
David Bryant (Cancer Research UK Beatson Institute, United Kingdom)
"The Small GTPase ARF3 Controls Invasion Modality and Metastasis by Regulating N-Cadherin Levels"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Holly Lovegrove (University of Manchester, UK, United Kingdom)
"Post-Mitotic Cell-Cell Adhesion During Collective Cell Migration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Interactions During Morphogenesis
Discussion Leader: Rashmi Priya (The Francis Crick Institute, London, United Kingdom)
7:30 pm - 8:00 pm
Crystal Rogers (UC Davis, United States)
"TUBB3 Mediates Cadherin Localization to Control Ectodermal Proliferation, Migration, and Survival"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Sara Stahley (Penn State College of Medicine, United States)
"Regulation of Planar Cell Polarity by Atypical Cadherin Celsr1"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Adam Martin (Massachusetts Institute of Technology, United States)
"Coordinating Embryo-Wide Cell Shape Changes During Tissue Folding"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Tissue Engineering and Tissue Models of Organoids
Discussion Leader: Sara Stahley (Penn State College of Medicine, United States)
9:00 am - 9:30 am
Ulrich Tepass (University of Toronto, Canada)
"Mitotic Polarity Oscillation and Epithelial Tumor Progression"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Mo Weng (University of Nevada Las Vegas, United States)
"Gish is a Novel Mechanosensitive Junction Interactor Required for Apical Constriction and Epithelial Folding"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Coryn Hoffman (Penn State College of Medicine, United States)
"A Novel Role for the Endoplasmic Reticulum (ER) as A Cell Adhesion Stress Sensor"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Rashmi Priya (The Francis Crick Institute, London, United Kingdom)
"How to Build a Functional Organ. Lessons from the Heart"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Sara Wickstrom (Max Planck Institute for Molecular Biomedicine, Germany)
"Coordination of Cell State Transitions and Morphogenesis by Mechanical Forces"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Katerina Ragkousi (Amherst College, United States)
"Novel Cell Adhesion Proteins in Nematostella Vectensis Epithelia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Interactions in Tumor Cell Invasion and Metastasis
Discussion Leader: Gaudenz Danuser (UT Southwestern Medical Center, United States)
7:30 pm - 8:00 pm
Jing Yang (University of California, San Diego, United States)
"Regulation of Epithelial-Mesenchymal Plasticity by Matrix Rigidity in Carcinoma Metastasis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Andrew Ewald (Johns Hopkins University, United States)
"The Role of Adhesion Receptors in Regulating Cancer Metastasis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Patrick Derksen (UMC Utrecht, The Netherlands)
"E-cadherin to F-actin Linkage Reveals Candidate Tumor Suppressors"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure