Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Molecular Basis of Vascular Intercellular Adhesion
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:40 pm
"Cell-Cell Junctions in Endothelial Fluid Shear Stress Mechanotransduction"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"How Leukocytes Cross the Endothelial Barrier: Spatiotemporal Endothelial Signals Control Extravasation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Insights into the Molecular Composition of Cell Contacts
9:00 am - 9:30 am
"Visualizing Cellular Force-Sensing Through the Actin Cytoskeleton"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"SGEF, a RhoG Specific GEF, Regulates E-Cadherin Stability, Turnover and Transcription in Epithelial Cells"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"A Short Isoform of Tensin1 is a Novel Regulator of Erythroblast Enucleation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Protein Phase Separation Promotes Integrin Receptor Clustering and Downstream Signaling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"The Tight Junction Inhibits Cancer Invasion and Metastasis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Role of ZO1 Membrane Condensation for Tight Junction Assembly"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Interactions at Desmosomes, Tight Junctions and Beyond
7:30 pm - 8:00 pm
"Reimagining the Desmosome as a Multi-Organelle Membrane Domain"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Nanoscale Desmosome Architecture and Cell-Cell Adhesion"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Exploring Cell Interactions
9:00 am - 9:30 am
"Physics of Cell Adhesion in the Regulation of Activation of Natural Killer Cells"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Maintenance and Remodeling of Epithelial Cell-Cell Junctions During Cell Shape Changes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:35 am
"The Adhesion Basis of Robust Spinal Cord Morphogenesis"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Group Photo / Coffee Break
11:10 am - 11:40 am
"Stable and Dynamic Forces in Integrin Based Adhesions"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"An Ensemble of Cadherin-Catenin-Vinculin Complex Employs Vinculin as the Major F-actin Binding Mode"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Afadin and Zonula Occludens-1 form Tension-Responsive Linkages to Nectin and Junctional Adhesion Molecule-A"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Interactions as Integrators of Mechanical Signals
7:30 pm - 8:00 pm
"Cell-Cell Recognition by Cadherin-Based Mechanotransduction."
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"The Role of Mechanical Forces and Cell-Cell Adhesion in the Fate of Extruding Cells"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Signals, Forces, and Cells: Decoding Tissue Morphogenesis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Interactions as Integrators of Cell Signaling
9:00 am - 9:30 am
"Proliferation Signaling from Pseudo-Adhesions"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Metabolic Control of Neural Crest Migration"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Contributions of BOC and CDON Adhesion Receptors to Cytoneme Mediated Sonic Hedgehog Morphogen Deployment and Reception"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"The Tight Junction Inhibits Cancer Invasion and Metastasis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"The Small GTPase ARF3 Controls Invasion Modality and Metastasis by Regulating N-Cadherin Levels"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Post-Mitotic Cell-Cell Adhesion During Collective Cell Migration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Interactions During Morphogenesis
7:30 pm - 8:00 pm
"TUBB3 Mediates Cadherin Localization to Control Ectodermal Proliferation, Migration, and Survival"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Regulation of Planar Cell Polarity by Atypical Cadherin Celsr1"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Coordinating Embryo-Wide Cell Shape Changes During Tissue Folding"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Tissue Engineering and Tissue Models of Organoids
9:00 am - 9:30 am
"Mitotic Polarity Oscillation and Epithelial Tumor Progression"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Gish is a Novel Mechanosensitive Junction Interactor Required for Apical Constriction and Epithelial Folding"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"A Novel Role for the Endoplasmic Reticulum (ER) as A Cell Adhesion Stress Sensor"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"How to Build a Functional Organ. Lessons from the Heart"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Coordination of Cell State Transitions and Morphogenesis by Mechanical Forces"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Novel Cell Adhesion Proteins in Nematostella Vectensis Epithelia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Interactions in Tumor Cell Invasion and Metastasis
7:30 pm - 8:00 pm
"Regulation of Epithelial-Mesenchymal Plasticity by Matrix Rigidity in Carcinoma Metastasis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"The Role of Adhesion Receptors in Regulating Cancer Metastasis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"E-cadherin to F-actin Linkage Reveals Candidate Tumor Suppressors"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure