Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Adhesion and Disease
Discussion Leader: Matthew Kutys (Boston University, USA)
3:45 pm - 3:50 pm
Opening Remarks
3:50 pm - 4:05 pm
Amber Caldara (Emory University, USA)
"A Novel Desmoglein 1 Mutation Abrogates Lipid Raft Targeting and Causes SAM Syndrome"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Adrian Luna (University of New Mexico Health Science Center, USA)
"The Interplay Between HPV Oncogene Expression and Contact Inhibition"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Adhesion Mechanics
Discussion Leaders: Junior West (University of Toronto, Canada) and Henri Huppert (Institute of Medical Biology, A*STAR, Singapore / University of Manchester, United Kingdom)
7:30 pm - 7:45 pm
Samantha Barrick (University of Illinois at Urbana-Champaign, USA)
"Salt Bridges Gate Alpha-Catenin Activation at Intercellular Junctions"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Anant Chopra (Boston University, USA)
"Force Generation via β-Muscle Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Focal Adhesions"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Anna-Lena Cost (Max Planck Institute of Biochemistry, Germany)
"Developing a Desmoplakin Tension Sensor"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Kathryn Rosowski (ETH Zurich, Switzerland)
"Stiffening and Reinforcement of Adherent Fibroblasts During Stretch and Its Vinculin Dependence"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Zainab Rahil (University of Illiniois at Urbana-Champaign, USA)
"Mechanoselectivity: Cell's Guide to Force Transduction"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Cornelia Schwayer (IST Austria, Austria)
"Mechanochemical Feedback Loop Driving Epithelial Tissue Spreading During Zebrafish Development"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Molecules to Organisms
Discussion Leaders: Anant Chopra (Boston University, USA) and Anna-Lena Cost (Max Planck Institute of Biochemistry, Germany)
9:00 am - 9:15 am
Shafali Gupta (Institute of Molecular Biosciences, University of Queensland, Australia)
"Active Response of E-Cadherin Junctions During Collective Cell Migration"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Junior West (University of Toronto, Canada)
"An Actomyosin-Arf-GEF Negative Feedback Loop for Tissue Elongation Under Stress"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Prateek Arora (Tata Institute of Fundamental Research, Mumbai, India)
"Reciprocal Interactions Between aPKC and Lgl with E-Cadherin Establish a Mechanically Robust Bi-Layered Epidermis During Zebrafish Development"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Teresa Bonello (University of North Carolina at Chapel Hill, USA)
"Defining the Network of Proteins Driving Apical-Basal Polarity Establishment in Early Drosophila Development"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Tony Tsai (Harvard Medical School, USA)
"Cracking the Adhesion Code Underlying Robust Pattern Formation in Zebrafish Spinal Cord"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Sarah Imtiaz (Max Planck Institute of Molecular Physiology, Germany)
"Studying the Formation and Function of Adhesion Sites by the Quantitative Multi-Parametric Analysis"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Remodeling Adhesion
Discussion Leader: Torey Arnold (University of Michigan, USA)
1:30 pm - 1:45 pm
Saranyaraajan Varadarajan (University of Michigan, USA)
"The Role of Calcium Influx in Remodeling of Epithelial Cell-Cell Junctions"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Henri Huppert (Institute of Medical Biology, A*STAR, Singapore / University of Manchester, United Kingdom)
"Regulation of Desmosome Internalisation"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Matthew Kutys (Boston University, USA)
"A Mechanosensitive Notch Complex Regulates Vascular Endothelial Junctions and Barrier Function"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
