Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Integrating Adhesion and Polarity to Shape Epithelial Barriers
Discussion Leader: Patrick Willoughby (University of Toronto, Canada)
3:15 pm - 3:55 pm
Carien Niessen (University of Cologne, Germany)
"Integrating Adhesion and Polarity to Shape Epithelial Barriers"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Adhesion During Morphogenesis
Discussion Leaders: Anna-Lena Cost (Max Planck Institute of Biochemistry, Germany) and Mateusz Sikora (Max Planck Institute of Biophysics, Germany)
5:30 pm - 5:45 pm
Debanjan Barua (University of Toronto, Canada)
"Molecular Modulation of Cell Adhesion Affects Structure and Organization of Distinct Classes of Cell-Cell Contacts Within Embryonic Tissues"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Shahana Chumki (University of Michigan, Ann Arbor, USA)
"Using Optogenetic Tools to Determine How Local Tight Junction Leaks and the Rho Flare Repair Mechanism Are Triggered"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Kia Perez (University of North Carolina at Chapel Hill, USA)
"Defining the Role of the Adherens Junction-Actin Cytoskeletal Linker Canoe/Afadin in Epithelia Integrity and Morphogenesis"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Tony Tsai (Harvard Medical School, USA)
"An Adhesion Code Enables Robust Pattern Formation in the Zebrafish Spinal Cord"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Patrick Willoughby (University of Toronto, Canada)
"The Small GTPase Rab25 Regulates Epithelial Cell Remodelling During Zebrafish Morphogenesis"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Wei Yang (The University of Hong Kong, Hong Kong SAR China)
"Vangl2 Phosphorylation Gradient Provides a New Model in Planar Cell Polarity Establishment"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Adhesion Dynamics
Discussion Leaders: Yekaterina Miroshnikova (Helsinki Institute of Life Science, Finland) and Saima Ahmed (Imperial College London, United Kingdom)
9:00 am - 9:15 am
Youmna Atieh (The University of Texas MD Anderson Cancer Center, USA)
"Dynamic Actomyosin Pulses Induce Tension Imbalance to Drive Epithelial Cell Extrusion"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Tiama Hamkins-Indik (University of California, Berkeley, USA)
"Affinity of ZO-1 to Actin Modulates Barrier Function"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Alexandra Rusu (University of Nottingham, United Kingdom)
"An In Vivo Loss-of-Function Analysis of Tumor Progression Identifies CG7379/ING1 as a Multifaceted Invasion Suppressor and a Regulator of Cell-Cell Junction Integrity"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Clémentine Villeneuve (Institut Curie, France)
"aPKCi Triggers Oncogenic Basal Extrusion by Modulating Vinculin Localisation and Cell Contractility"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Mateusz Sikora (Max Planck Institute of Biophysics, Germany)
"Truss-Like Arrangement of Cadherins Is Responsible for Desmosome Strength"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Qiutan Yang (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"Tissue Self-Organized Mechanical Forces in Intestinal Organoid Crypt Morphogenesis"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Physics of Adhesion
Discussion Leader: Debanjan Barua (University of Toronto, Canada)
1:30 pm - 1:45 pm
Mahesh Agarwal (Indian Association for the Cultivation of Science, India)
"Cellular Adhesion and Rheology Control Differentiation, Phagocytosis and Pattern Formation"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Anna-Lena Cost (Max Planck Institute of Biochemistry, Germany)
"The Desmosome Is Mechanically Loaded in Response to Externally Applied Stress"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Alicia Salvi (University of Iowa, USA)
"Investigating the Metabolic Changes in Response to Force on E-Cadherin"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
