Sunday June 29th, 1997
- 2:00-6:00 pm - REGISTRATION
- 6:00 pm - DINNER
- 7:30-9:30 pm - Session 1: Introduction to Conference
- 7.30-7.-50pm - Welcome and Orientation - Martin Tenniswood, W. Alton Jones Cell Science Center, Lake Placid, NY
- 7:50-8:15pm - Philosophy and Objectives - Douglas Green, La Jolla Institute for Allergy and Immunology, San Diego, CA
- 8:15-8:45pm - Overview of apoptosis, identification of critical issues - Richard Lockshin, St. John's University, Jamaica, NY
- 8:45-9:15pm - Discussion
- 9:15pm - RECEPTION
Monday, June 30th 1997
- 7:00-9:00am - BREAKFAST
- 9:00am-12.30pm - Session 2: Membrane Molecules, Death Domains and Death Effector Domains
Discussion Leader: Dr. Richard Kolesnick, Memorial Sloan-Kettering Cancer Center,New York, NY
- 9:00-9:20am - Introduction to Session by Discussion Leader
- 9:20-9:45am - Complexity of DNA fragmentation in apoptosis: evidence for more than one pathway - Dr. Roy Walker, National Research Council of Canada, Ottawa, Ontario, Canada
- 9:45-10:00am - Discussion
- 10:00- 10:25am - Ceramide: an endogenous mediator of the stress response - Dr. Yusef Hannun, Duke University Medical Center, Durham, NC
- 10:25-10:40am - Discussion
- 10:40-1 1 -.00am - COFFEE BREAK
- 11:00- 11:25am - Title to be announced - Dr. Richard Kolesnick, Memorial Sloan-Kettering Cancer Center, New York, NY
- 11:25-11:40 - Discussion
- 11:40- 12:05 protective roles of cytokines against radiation: induction Of mitochondrial MNSOD - Dr. Grace Wong, Millennium Pharmaceuticals, Cambridge, MA
- 12:05-12:25 - Discussion
- 12:30 pm - LUNCH
- 4:00-6:00pm - POSTER SESSION 1
- 6:00-7:30 pm - DINNER
- 7:30-10:00 pm - Session 3: p53, DNA damage and apoptosis
Discussion Leader: Dr. John Hickman, Paterson Institute for Cancer Research, Manchester, United Kingdom
- 7.30-7.50 pm - Introduction to Session by Discussion Leader
- 7.50-8:15pm - P53-dependent and independent apoptotic pathways of chemotherapy induced apoptosis - Dr. Scott Lowe, Cold Spring Harbor Laboratories, Cold Spring Harbor, NY
- 8:15-8:30pm - Discussion
- 8:30-8:55pm - Granzyme B (GraB) activation of apoptosis - Dr. Arnold Greenberg - University of Manitoba, Winnipeg, Manitoba, Canada
- 8:55-9:1 Opm - Discussion
- 9:10-9:35pm - Nur77 and Notch- I cooperate in the regulation of death - Dr. Barbara Osborne, University of Massachusetts, Amherst, MA
- 9:35-9:50pm Discussion
- 10:00pm- whenever - Informal discussions at bar without set time limits
Tuesday, July lst 1997
- 9:00am-12.30pm - Session 4: Executioner
Discussion Leader: Dr. Mark Wilson, University of Wollongong, Australia
- 9:00-9:20am - Introduction to session by Discussion Leader
- 9:20-9:45 am - CED/ICE-like proteases: transducers and executioners of apoptosis - Dr. Emad Alnemri, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA
- 9:45-10:00am - Discussion
- 10:00-10:25am - The central executioner of apoptosis: mitochondria and/or proteases? - Dr. Guido Kroemer, Centre National de la Recherche Scientifique, Villejuif, France
- 10:25-10:40am - Discussion
- 10:40-11:00am - COFFEE BREAK
- 11:00- 11:25am - Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria - Dr. Donald Newmeyer, La Jolla Institute for Allergy and Immunology, San Diego, CA
- 11:25-11:40am - Discussion
- 11:40-12:05 - Biochemical characterization of CPP32 activation processes in cefl free systems - Dr. Xiaodong Wang, South Western Medical Center, Dallas, TX
- 12:05-12:25pm - Discussion
- 12:30pm - LUNCH
- 3:30-5:30pm - Selected Short Oral Presentations
- 6:00-7:30 pm - DINNER
- 7:30- 9:30pm - Session 5: Nuclear Events, DNA Fragmentation and Proteases
Discussion Leader: Dr. Chris Bleackley, Department of Biochemistry, University of Alberta, AB, Canada
- 7.30- 7.50pm - Introduction to Session by Discussion Leader
- 7.50-8:15pm - Structural Insights into the function of Bcl-2 related proteins - Dr. Craig Thompson, Howard Hughes Medical Institute, University of Chicago, Chicago, IL
- 8:15-8-.30pm - Discussion
- 8:30-8:55pm - Nuclear substrates for ICE family proteases: active participants in cellular execution or innocent bystanders? - Dr. Seamus Martin, Maynooth University College, Maynooth, Ireland
- 8:55-9:10pm - Discussion
- 9:10-9:35pm - A potential mechanism of cross-talk between the p55 tumor necrosis factor receptor and FaslAPO- I - Dr. David Wallach, Weizman Institute of Science, Rehovot, Israel
- 9:35-9-.50pm - Discussion
- 10:00pm- whenever - Informal discussions at bar without set time limits
Wednesday, July 2nd 1997
- 7:00-9:00am - BREAKFAST
- 9:00am-12:30pm - Session 6: Inhibitors of apoptosis
Discussion Leader: Dr. Michael Hengartner, Cold Spring Harbor Laboratories, Cold Spring Harbor, NY
- 9:00-9:20am - Introduction to session by Discussion Leader
- 9:20-9:45 am - Bcl-2 and other cellular inhibitors of apoptosis: mechanisms of action - Dr. John Reed, The Burnham Institute, LaJolla, CA
- 9:45-10:00am - Discussion
- 10:00-10:25am - Identification and characterization of insect IAPS and their dimerization partners - Dr. Lois Miller, University of Georgia, Athens, GA
- 10:25-10:40am - Discussion
- 10:40-11:00am - COFFEE
- 11:00-11:25am - Viral and cellular inhibitors of apoptosis (IAP) proteins - Dr. David Vaux, Walter and Eliza Hall Institute, Victoria, Australia
- 11:25-11:40am - Discussion
- 11:40-12:05pm - Neuronal apoptosis: molecular mechanisms and potential role in ischemic brain injury - Dr. Monanish Deshmukh, Washington University School of Medicine, St Louis, MO
- 12:05-2:20pm - Discussion
- 12:30pm - LUNCH
- 3:30-5:30pm - POSTER SESSION 2
- 6:00 pm - DINNER
- 7:30-10:00pm - Session 7: Phagocytosis and membrane mediated signalling
Discussion Leader: Dr. Zahra Zakeri, Department of Biology, CUNY
- 7:30-7:50pm - introduction to Session by Discussion Leader
- 7.50-8:15pm - Signals in Cell Death - Dr. Zahra Zakeri, Department of Biology, CUNY
- 8:15-8:30pm - Discussion
- 8:30-8:55pm - Transbilayer redistribution of phosphatidylserine targets apoptotic lymphoid cells for destruction - Dr. Robert Schlegel, Pennsylvania State University, University Park, PA
- 8:55-9:10pm - Discussion
- 9:10-9:35pm - The role of platelet activating factor in neuronal apoptosis and progressive neurodegeneration - Dr. Steffany Benneft, W. Alton Jones Cell Science Center, Lake Placid, NY
- 9:35-9:50pm - Discussion
- 10:00pm-whenever - Informal discussions at bar without set time limits
Thursday, July 3rd, 1997
- 9:00-12:30pm - Session 8: Organismal Perspectives of Apoptosis
Discussion Leader: Dr. Marianna Sikorska, National Research Council of Canada, Ottawa, Ontario, Canada
- 9:00-9:20am Introduction to session by Discussion Leader
- 9:20-9:45am - Retinoid regulated expression of tissue transglutaminase: insights into the molecular mechanisms of apoptosis - Dr. Laszlo Nagy, Gene Expression Laboratory, The Salk Institute, LaJolia CA
- 9:45-10: 00am - Discussion
- 10:00-10:25am - Ovarian cell death signalling pathways and prevention of chemotherapy induced oocyte destruction - Dr. Johnathan Tilly, Vincent Center for Reproductive Biology, Harvard Medical School, Boston, MA
- 10:25-10:40am - Discussion
- 10:40-1 1:00am - COFFEE BREAK
- 11:00-11:25am - Genetic modulation of retinal apoptosis - Dr. David Papermaster, University of Connecticut Health Center, Farmington, CT
- 11:25-11:40am - Discussion
- 11:40-12:05 pm - The immune system, apoptosis and the eye - Dr. Tom Ferguson, Washington Oniversity School of Medicine, St. Louis, MO
- 12:05-12:20pm - Discussion
- 12:30pm - LUNCH
- 3:30-5:30pm - Selected Short Oral Presentations-2
- 6:00 pm - BANQUET
- 7:30pm - Session 9: LESSONS
Discussion Leader: Martin Tenniswood
- 7.30-8:10pm - Lessons from Phylogeny - Dr. Jean-Claude Ameisen, Hopital Bichat-Claude Bernard, Paris, France
- 8:10-8:30pm - Discussion
- 8:30-9:10pm - Lessons from the Test Tube - Dr. Yuri Lazebnick, Cold Spring Harbor Laboratories, Cold Spring Harbor, NY
- 9:10-9:25pm - Discussion
- 9:25-9:45pm - Lessons from the Conference-Closing Remarks
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