| SUNDAY |
| 2:00pm - 9:00pm | Arrival and check-in |
| 6:00pm | Dinner |
| 7:30pm - 8:00pm | Welcome and announcements:
Sally Kornbluth, Chair, (Duke University MedicalCenter)
Michael Hengartner, Vice-chair, (University of Zurich, Switzerland) |
| Keynote Address |
| 8:00pm - 9:00pm | David L. Vaux (The Walter and Eliza Hall Institute, Australia)
There are two families of BIR-containing proteins: those that inhibit apoptosis and those required for cytokinesis |
| 9:00pm - 9:15pm | Discussion |
| MONDAY |
| 7:30am - 8:30 am | Breakfast |
| 9:00 am-12:00pm | Bcl-2 Family |
| Discussion Leader: Gabriel Nunez (U. Michigan) |
| 9:00 - 9:25 | Marie Hardwick (Johns Hopkins University)
The Role of Bcl-2 Family Proteins in Virus Infections and Neuronal Disease |
| 9:25 - 9:50 | Richard Youle (NIH)
Regulation of Bax mitochondrial translocation |
| 9:50 - 10:05 | Discussion |
| 10:05 - 10:30 | Stanley Korsmeyer (Dana Farber Cancer Institute, Harvard)
The Mitochondrial Gateway to Apoptosis |
| 10:30 - 10:40 | Discussion |
| 10:40 - 11:00 | Coffee Break |
| 11:00 - 11:25 | Craig Thompson (University of Pennsylvania)
Distinguishing Between Genes That Promote Cell
Surival and Those That Prevent Cell Death |
| 11:25 - 11:40 | Discussion |
| 11:40 - 12:05 | Eileen White (Rutgers University)
Regulation of Apoptosis by the Transforming Genes of Adenovirus |
| 12:05 - 12:20 | Discussion |
| 12:30 | Lunch |
| 1:30pm-4:00 | Free time |
| 4:30 - 6:00 | Poster Session/Informal short talks |
| 6:00 | Dinner |
| 7:30-9:30 pm | Signaling Molecules Regulating Cell Death |
| Discussion leader: Kristin White (Massachusetts General Hospital, Harvard) |
| 7:30 - 8:00 | Richard Flavell (Yale University)
Physiological roles of capases |
| 8:00 - 8:15 | Discussion |
| 8:15 - 8:45 | Adi Kimchi (Weizmann Institute, Israel)
Funtion-based genetic selections for the rescue of death-promoting and tumor suppressor genes |
| 8:45 - 9:00 | Discussion |
| 9:00 - 9:30 | Jean Wang (University of California, San Diego)
Death by Abl, a Matter of Location |
| 9:30 - 9:45 | Discussion |
| 10:00 | Continued Discussion in Common Room |
| TUESDAY |
| 7:30am - 8:30 am | Breakfast |
| 9:00-12:30 | Disease and Inflammation |
| Discussion Leader: Richard Flavell (Yale) |
| 9:00 - 9:25 | Stuart Lipton (The Burnham Institute)
Protection from neuronal apoptosis mediated by erythropoietin-induced cross talk between the Jak2 and NF-kappaB pathways. |
| 9:25 - 9:50 | Gabriel Nunez (University of Michigan, Ann Arbor)
Apaf-1-Like Molecules Regulating the Host Response to Pathogens |
| 9:50 - 10:05 | Discussion |
| 10:05 - 10:30 | Chris Bleakley (University of Alberta, Canada)
Cytotoxic T Cell-induced apoptosis |
| 10:30 - 10:40 | Discussion |
| 10:40 - 11:00 | Coffee Break |
| 11:00 - 11:25 | Junying Yuan (Harvard Medical School)
The Peutz-Jegher Gene Product LKB1 is a Mediator of p53-dependent Cell Death in the Small Intestine |
| 11:25 - 11:40 | Discussion |
| 11:40 - 12:05 | Vishva Dixit (Genentech, San Francisco) |
| 12:05 - 12:20 | Discussion |
| 12:30 | Lunch |
| 1:30-4:00 | Free Time |
| 4:30 - 6:00 | Poster Session/Informal short talks |
| 7:30-9:30 | Death Receptors |
| Discussion Leader: Vishva Dixit (Genentech, San Francisco) |
| 7:30 - 8:00 | Marcus Peter (University of Chicago)
CD95 Signal Initiation |
| 8:00 - 8:15 | Discussion |
| 8:15 - 8:45 | Jurg Tschopp (University of Lausanne, Switzerland)
Death domain-like modules in cell death and inflammation |
| 8:45 - 9:00 | Discussion |
| 9:00 - 9:30 | K. Debatin (University Children's Hospital, Germany)
|
| 9:30 - 9:45 | Discussion |
| 10:00 | Continued Discussion in Common Room |
| WEDNESDAY |
| 7:30am - 8:30 am | Breakfast |
| 9:00-12:30 | Genetics of Apoptosis |
| Discussion Leader: Marie Hardwick (Johns Hopkins) |
| 9:00 - 9:25 | John Abrams (UT Southwest)
Cell killing by Reaper, Grim and Hid proteins in Drosophila Melanogaster |
| 9:25 - 9:50 | Monica Driscoll (Rutgers University)
Genetics of necrotic cell death in C. elegans |
| 9:50 - 10:05 | Discussion |
| 10:05 - 10:30 | Tak Mak (Amgen Institute, University of Toronto)
Bcl-10 and cell death signaling in MALT lympomas |
| 10:30 - 10:40 | Discussion |
| 10:40 - 11:00 | Coffee Break |
| 11:00 - 11:25 | Barbara Osborne (University of Massachusetts, Amherst)
Notch as a Regulator of Cell Death in T cells and Drosophila |
| 11:25 - 11:40 | Discussion |
| 11:40 - 12:05 | Kristin White (Massachusetts General Hospital, Harvard)
Genetic analysis of Cell Death in Drosophila |
| 12:05 - 12:20 | Discussion |
| 12:30 | Lunch |
| 4:30 - 6:00 | Poster Session/Informal short talks |
| 7:30-9:30 | Mitochondria and Apoptotic Regulation |
| Discussion Leader: Douglas Green (La Jolla Institute of Allergy and Immunology) |
| 7:30 - 8:00 | Donald Newmeyer (La Jolla Institute of Allergy and Immunology)
Mechanisms of mitochondrial cytochrome c release |
| 8:00 - 8:15 | Discussion |
| 8:15 - 8:45 | Guido Kroemer (Institute Gustav Roussy, France)
Mitochondrial control of cell death in the context of HIV-1 infection |
| 8:45 - 9:00 | Discussion |
| 9:00 - 9:30 | Roberta Gottleib (The Scripps Institute)
Mitochondrial function in calcineurin transgenic mice |
| 9:30 - 9:45 | Discussion |
| 10:00 | Continued Discussion in Common Room |
| THURSDAY |
| 7:30am - 8:30 am | Breakfast |
| 9:00-12:30 | Caspases and their Regulators (and a bit of engulfment too) |
| Discussion leader: Junying Yuan (Harvard) |
| 9:00 - 9:25 | Guy Salvesen (Burnham Institute, La Jolla, CA)
To live or die: Regulation of apoptosis at the molecular level |
| 9:25 - 9:50 | Colin Duckett (NIH)
Novel modulators of the apoptotic cell death pathway |
| 9:50 - 10:05 | Discussion |
| 10:05 - 10:30 | Gerald Cohen (University of Leicester, United Kingdom)
IAPs, Apaf-1, and regulation of the Apoptosome |
| 10:30 - 10:40 | Discussion |
| 10:40 - 11:00 | Coffee Break |
| 11:00 - 11:25 | Don Nicholson (Merck-Frosst, Canada)
Caspase Function and Modulation |
| 11:25 - 11:40 | Discussion |
| 11:40 - 12:05 | Giovanna Chimini (Inserm/CNRS France)
Membrane lipid architecture in macrophage competence to engulf
|
| 12:05 - 12:20 | Discussion |
| 12:30 | Lunch |
| 4:30 - 6:00 | The Gordon Conference Business Meeting |
| 6:00 | Dinner |
| 7:30-9:30 | p53, Oncogenes, and Cell Death Regulation |
| Discussion Leader: Barbara Osborne (Univ. of Massachusetts) |
| 7:30 - 8:00 | Douglas Green (La Jolla Institute of Allergy and Immunology)
Stress and the control of apoptosis |
| 7:30-7:45 | Discussion |
| 7:45-8:15 | Karen Vousden (National Cancer Institute)
Regulation of Cell Growth and Death by p53 |
| 8:15 - 8:45 | Discussion |
| 8:45-9:15 | Gerard Evan (Univ. California, San Francisco) |
| 9:15-9:45 | Marja Jaattela (Danish Cancer Society, Denmark)
Control of tumor cell apoptosis by Heat shock protein 70 |
| 9:45-10:00 | Discussion |
| 10:00 | Party |
