| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Survival Proteins |
| Discussion Leader: David Vaux (The Walter and Eliza Hall Institute) |
| 7:30 pm - 8:00 pm | David Vaux (The Walter and Eliza Hall Institute)
"Homeostatic control of IAP abundance" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Joseph Opferman (Dana-Farber Cancer Institute)
"Obligate Roles for Anti-Apoptotic MCL-1 in Hematopoiesis" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Ewa Michalak (The Walter and Eliza Hall Institute)
"The role of BH3-only proteins in DNA damage-induced apoptosis" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Photo |
| 9:00 am - 12:30 pm | Caspase Pathways |
| Discussion Leader: Guy Salvesen (The Burnham Institute) |
| 9:00 am - 9:30 am | Guy Salvesen (The Burnham Institute)
"IAPs: caspase inhibitors or caspase regulators?" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Yuri Lazebnik (Cold Spring Harbor Laboratory)
"Apoptosis and oncogenic transformation" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Peter Vandenabeele (University of Gent)
"Necrotic cell death: a controlled way of cellular explosion" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Jurg Tschopp (University of Lausanne)
"Characterization of caspase-activating complexes" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Short talk: Andreas Lengeling (German Research Centre for Biotechnology)
"Characterization of phosphatidylserine receptor function(s) in the mouse" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Alternative Death Pathways |
| Discussion Leader: Maria Jäättelä (Danish Cancer Society) |
| 7:30 pm - 8:00 pm | Maria Jäättelä (Danish Cancer Society)
"Multiple cell death pathways as regulators of tumour initiation and progression" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Eric Baehrecke (University of Maryland)
"Genetic regulation of autophagic cell death during development |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Valina L. Dawson (Johns Hopkins University)
"PAR is a novel nuclear death signal" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regulation of Apoptosis |
| Discussion Leader: Doug Green (La Jolla Institute for Allergy and Immunology) |
| 9:00 am - 9:30 am | Doug Green (La Jolla Institute for Allergy and Immunology)
"Dances with mitochondria" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Shigekazu Nagata (Osaka University Medical School)
"Development of autoimmune disease by defects in clearance of apoptotic cells" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Barbara Conradt (Dartmouth Medical School)
"Regulation and initiation of programmed cell death in C. elegans" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Mike Hemann (Cold Spring Harbor Laboratory)
"Uncoupling proliferation from apoptosis during tumor development" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Short talk: David Helfman (University of Miami School of Medicine)
"The actin cytoskeleton and actomyosin contractility in cell survival" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mitochondria |
| Discussion Leader: Richard Youle (National Institutes of Health) |
| 7:30 pm - 8:00 pm | Wei-Xing Zong (University of Pennsylvania)
"Can necrosis be a programmed cell fate?" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Richard Youle (National Institutes of Health)
"Bax, mitochondria morphology and apoptosis" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Ute Moll (SUNY at Stony Brook)
"p53 has a direct apoptogenic role at the mitochondria in vivo" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Translational Research |
| Discussion Leader: Klaus-Michael Debatin (University Children Hospital, Ulm) |
| 9:00 am - 9:30 am | Saul Rosenberg (Abbott Laboratories)
"Small molecule inhibitors of Bcl-2 family proteins" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Robert Armstrong (Idun Pharmaceuticals Inc.)
"Therapeutic applications of apoptosis modulation" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Klaus-Michael Debatin (University Children Hospital, Ulm)
"Cell death signalling in cancer therapy" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Shailaja Kasibhatla (Maxim Pharmaceuticals)
"Reversing apoptotic resistance in cancer" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Short talk: Petra Ross-MacDonald (Bristol-Myers Squibb)
"Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Apoptosis Signaling |
| Discussion Leader: Peter H. Krammer (German Cancer Research Center) |
| 7:30 pm - 8:00 pm | Peter H. Krammer (German Cancer Research Center)
"The death of a T cell" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | John Eriksson (University of Turku)
"Transcription-independent control of death receptor signaling" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Li Yu (National Institutes of Health)
"The regulation of autophagic cell death in mammalian cells" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Engulfment |
| Discussion Leader: Nathalie Franc (University College London) |
| 9:00 am - 9:30 am | Nathalie Franc (University College London)
"Phagocytosis of apoptotic cells by Drosophila macrophages: a genetic study" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Kodi S. Ravichandran (University of Virginia)
"Signaling to engulfment: The beginnings of a good meal" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Valerian E. Kagan (University of Pittsburgh)
"Oxidative lipidomics of apoptotic signaling" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Christopher D. Gregory (University of Edinburgh)
"Clearance of apoptotic cells by macrophages in normal tissues and tumours" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Short talk: Giovanna Chimini (Marseille)
"ABCA1 influences CED-1-like engulfment receptors" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 8:00 pm | Business meeting |
| 8:00 pm - 9:00 pm | Keynote Lecture |
| Discussion Leader: J. Marie Hardwick (Johns Hopkins University) |
| 8:00 pm - 8:50 pm | Sally Kornbluth (Duke University)
"A tale of two Reapers" |
| 8:50 pm - 9:00 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
