SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments |
7:40 pm - 9:30 pm | Cell Death Perspectives and New Insights |
| Discussion Leader: Doug Green (St. Jude Children's Research Hospital) |
7:40 pm - 8:05 pm | Doug Green (St. Jude Children's Research Hospital)
"Life after MOMP?" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Sally Kornbluth (Duke University)
"Links between metabolism and apoptosis in the oocyte" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | David Vaux (La Trobe University, Australia)
"Mammalian IAPs and the proteins that bind to them: important, or not?" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | New Pathways and Therapeutic Targets |
| Discussion Leader: Vishva Dixit (Genentech) |
9:00 am - 9:25 am | Vishva Dixit (Genentech)
"The Inflammasome, a dynamic caspase activating apparatus" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Tudor Moldoveanu (McGill University)
"Bak - A Zinc-Inhibited Redox Sensor?" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Gabriel Nuñez (University of Michigan)
"Role of NOD-like receptors in Host Defense and Disease" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Peter Vandenabeele (Ghent University)
"Skin differentiation as a specialized form of cell death and the implication of caspases" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Short talk: Brent Stockwell (Columbia University)
"Context-dependent cell death in cancer and neurodegeneration" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Short talk: Srinivas Chunduru (Tetralogic)
"Potent antitumor activity of small molecule IAP antagonists" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I (N-Z) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Death-Survival Conflicts in the Nervous System |
| Discussion Leader: Pierluigi Nicotera (University of Leicester - UK) |
7:30 pm - 7:55 pm | Pierluigi Nicotera (University of Leicester - UK)
"Calcium signals and neuronal death/survival" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Elizabeth Jonas (Yale University)
"Synaptic apoptosis: Regulation of synaptic transmission by BCL-xL" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Zheng Li (National Institutes of Health/NIMH)
"The mitochondrial apopototic pathway in synaptic plasticity" |
9:05 pm - 9:15 pm | Discussion |
9:15 am - 9:25 pm | Short talk: Suzanne Zukin (Albert Einstein)
"Ischemic preconditioning: Neuronal survival in the face of caspase-3 activation" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | More Informal Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mitochondria Structure and Function |
| Discussion Leader: Richard Youle (National Institutes of Health / NINDS) |
9:00 am - 9:25 am | Richard Youle (National Institute for Neurological Disease and Stroke)
"Role of Bax and Bak in mitochondrial morphogenesis" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | David Nicholls (The Buck Institute)
"The interplay of oxidative stress and energy crises in neuronal cell death" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Len Kaczmarek (Yale University)
"BCL-2 proteins regulate mitochondrial ion channels and strength of neuronal signaling" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Ian Dawes (University of New South Wales)
"Cellular responses to redox imbalance" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Short talk: Sung-Ok Yoon (Ohio State)
"Activation of JNK3 after injury induces cytochrome c release by facilitating Pin1-dependent degradation of Mcl-1" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Short talk: Emad Alnemri (Thomas Jefferson University) "The pyrin inflammasome in autoinflammatory diseases" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I (N-Z) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Molecular Mechanisms of Cell Death |
| Discussion Leader: Junying Yuan (Harvard) |
7:30 pm - 8:05 pm | Junying Yuan (Harvard)
"A chemiproteomic approach for studying ER stress induced cell death signaling pathways" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Kristin White (Harvard)
"Mitochondrial disruption in Drosophila apoptosis" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Emily Cheng (Washington University)
"Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies" |
9:05 pm - 9:15 pm | Discussion |
9:15 am - 9:25 pm | Short talk: Clark Distelhorst (Case Western)
"Life-death decisions in immature T cells are encoded by distinct Bcl-2 sensitive and insensitive Ca2+ signals" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | More Informal Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Non-Apoptotic Pathways |
| Discussion Leader: Tak Mak (Toronto, Canada) |
9:00 am - 9:25 am | Tak Mak (Campbell Family Institute, Toronto)
"Scythe no more, ladies, scythe nor more" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Eric Baehrecke (University of Maryland)
"Genetic regulation of autophgic programmed cell death" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Karen Vousden (The Beatson Institute, Scotland)
"Pro- and anti-apoptotic functions of p53" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Fedor Severin (Belozersky Institute, Moscow)
"Modeling programmed cell death in yeast" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Short talk: Kevin Ryan (Beatson Institute, Glasgow)
"Linking cell death to drug resistance downstream of E2F1" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Short talk: Hannah Heath-Engel (McGill University, Canada)
"ER-restricted BCL-2 inhibits cell death induced by p20BAP31 in BAX/BAK-double knockout mouse cells" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II (A-M) |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Cell Death Mechanisms in Cancer and Aging |
| Discussion Leader: Jean Wang (UCSD Cancer Center) |
7:30 pm - 7:55 pm | Jean Wang (University of California San Diego)
"Impaired Caspase-8 Activation by Type I TNF Receptor in Cells Expressing Caspase-Resistant RB" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Richard Flavell (Yale University)
"Kinase signaling cascades to caspase activation" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Valter Longo (University of Southern California)
"A Cell Death and Aging Regulatory Network" |
9:05 pm - 9:15 pm | Discussion |
9:15 am - 9:25 pm | Short talk: Milton Werner (Rockefeller University)
"Defining the mechanism of TNF receptor-mediated cell death: bridging FADDs cluster death receptors to assemble extended cell-killing arrays with a dispensable transmembrane domain" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | More Informal Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Death in Disease Pathogenesis |
| Discussion Leader: Eileen White (Rutgers University) |
9:00 am - 9:25 am | Eileen White (Rutgers University)
"Role of autophagy in cancer" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Yoshihide Tsujimoto (Osaka University, Japan)
"Cell death induced by ischemia/reperfusion" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Richard Kolesnick (Sloan-Kettering Cancer Institute)
"Ionizing radiation remodels mitochondrial membranes to facilitate Bax insertion" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Nigel Waterhouse (Peter Mac Institute, Australia)
"Cell Wars; cell killing by cytotoxic lymphocytes" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Short talk: Yonatan Tzur (Hebrew University)
"Matefin/SUN-1 is a nuclear envelope receptor for CED-4" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Short talk: Blake Hill (Johns Hopkins)
"C. elegans CED-9 retains apoptotic regulatory functions in the absence of the C-terminal mitochondrial localization signal" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II (A-M) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Lecture |
7:30 pm - 8:20 pm | Keynote Speaker: Michael Hengartner (Universität Zürich)
"Roads to ruin: apoptotic pathways in the nematode C. elegans" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Short talk: Brendan Eckelman (Burnham Institute)
"Elucidating the consequences of NAIP/caspase interactions" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Short talk: Wen-Chih Cheng (Johns Hopkins)
"Activation of the TOR pathway compensates for loss of mitochondrial fission protein in yeast" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Short talk: Heidi Galonek (Johns Hopkins)
"Bcl-12, a novel Bcl-2 family protein, regulates Bcl-xL" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm - | More Informal Discussion / Special Entertainment |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |