SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | CELL DEATH PERSPECTIVES AND INSIGHTS |
| Discussion Leader: Guy Salvesen (Burnham Institute) |
7:45 pm - 8:10 pm | Michael Hengartner (University of Zurich)
"Regulation of programmed cell death in C. elegans" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Sally Kornbluth (Duke University)
"Cell Death in the oocyte" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Douglas Green (St. Judes Children's Research Hospital)
"Life after cytochrome c release: The iMOMP adventure" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | THE DIVERSITY OF DEATH PATHWAYS |
| Discussion Leader: Sally Kornbluth (Duke University) |
9:00 am - 9:05 am | Introduction |
9:05 am - 9:30 am | John Abrams (University of Texas Southwestern Medical Center)
"Programmed, Unprogrammed and Collective Cell Death" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Eric Baehrecke (University of Massachusetts)
"Genetic regulation of autophagic cell death in Drosophila" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break / Group Photo |
10:45 am - 11:10 am | Jennifer Cox (University of British Columbia)
"Delayed neutrophil apoptosis in MMP deficient mice" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Gary Silverman (University of Pittsburgh)
"Are intracellular serpins antidotes to necrotic cell death?" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Boris Turk (Josef Stefan Institute)
"Lysosomal pathways to cell death" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session 1 |
5:30 pm - 7:30 pm | DEATH RECEPTORS |
| Discussion Leader: Eric Baehrecke (University of Massachusetts) |
5:30 pm - 5:40 pm | Introduction |
5:40 pm - 6:05 pm | Avi Ashkenazi (Genentech)
"New insights into proapoptotic receptor signaling" |
6:05 pm - 6:15 pm | Discussion |
6:15 pm - 6:40 pm | Andreas Strasser (Walter and Eliza Hall Institute of Medical Research)
"Death ligand-death receptor signaling revisited" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Stefan Riedl (Burnham Institute)
"Death inducing complexes" |
7:15 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
9:30 pm | More Informal Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PHARMACEUTICAL STRATEGIES |
| Discussion Leader: Huseyin Mehmet (Merck) |
9:00 am - 9:05 am | Introduction |
9:05 am - 9:30 am | Vishva Dixit (Genentech)
"Targeting the Inhibitor of Apoptosis Proteins" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | David Vaux (La Trobe University)
"IAPs - Structure/Function" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Colin Duckett (University of Michigan)
"Multiple roles for IAPs in apoptosis and intracellular signaling" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Phil Barker (McGill University)
"Mechanisms of IAP-induced cancer cell survival" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Bree Aldridge (Harvard Medical School)
"Quantitative analysis of the mitochondrial-pathway requirement for receptor-mediated apoptosis in single cell" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session 2 |
5:30 pm - 7:30 pm | MOLECULAR BASES OF CELL DEATH - 1 |
| Discussion Leader: Vishva Dixit (Genentech) |
5:30 pm - 5:40 pm | Introduction |
5:40 pm - 6:05 pm | Francesca Marassi (Burnham Institute)
"Membrane mediated interactions of the Bcl2 family proteins" |
6:05 pm - 6:15 pm | Discussion |
6:15 pm - 6:40 pm | Hao Wu (Weill Cornell Medical College)
"Assembly of death domain complexes: versatile platform for variable components and stoichiometry" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Seamus Martin (Trinity College Dublin)
"Uncoupling Bax/Bak-initiated mitochondrial fragmentation and apoptosis" |
7:15 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
9:30 pm | More Informal Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DEATH/SURVIVAL IN THE NERVOUS SYSTEM |
| Discussion Leader: Douglas Green (St. Judes Children's Research Hospital) |
9:00 am - 9:05 am | Introduction |
9:05 am - 9:30 am | Mohanish Deshmukh (University of North Carolina)
"Death Defying Tricks in Neurons and Cancer Cells" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Carol Troy (Columbia University)
"Is beta-amyloid an obligate killer?" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Mauro Piacentini (University of Rome)
"Regulation of autophagy in mammals by AMBRA1 and its partners" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Christine Hawkins (La Trobe University)
"Exploiting yeast to probe caspase specificity and regulation" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Ben Hoffstrom (Columbia University)
"Connecting protein misfolding to apoptosis: a novel role for chaperone proteins" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session 3 |
5:30 pm - 7:30 pm | MOLECULAR BASES OF CELL DEATH - 2 |
| Discussion Leader: David Vaux (La Trobe University) |
5:30 pm - 5:40 pm | Introduction |
5:40 pm - 6:05 pm | Xuejun Jiang (Memorial Sloan-Kettering Cancer Center)
"Targeting the apoptosome" |
6:05 pm - 6:15 pm | Discussion |
6:15 pm - 6:40 pm | Gerry Melino (University of Rome)
"p73, apoptosis and cancer: is it a tumor suppressor?" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | John Reed (Burnham Institute)
"Endoplasmic Reticulum Stress and Cell Death Regulation" |
7:15 pm - 7:25 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
9:30 pm | More Informal Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CELL DEATH FATES IN CANCER |
| Discussion Leader: Colin Duckett (University of Michigan) |
9:00 am - 9:05 am | Introduction |
9:05 am - 9:30 am | Jan-Paul Medema (University of Amsterdam)
"Betulinic acid induced cell death. A bit of everything?" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Pascal Meier (Institute of Cancer Research)
"Ubiquitin-mediated survival signalling" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Eileen White (Rutgers University)
"Role of Autophagy in in Tumor Suppression and Therapeutic Response" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Peter Vandenabeele (University of Gent)
"Identification and validation of caspase substrates" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Jurg Tschopp (University of Lausanne)
"The PIDDosome and detection of UV damage" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session 4 |
5:30 pm - 6:55 pm | LATE BREAKING HOT TOPICS |
| Discussion Leader: Richard Youle (NINDS) |
5:30 pm - 5:50 pm | Sharad Kumar (Hanson Institute)
"Caspase-2 function in cell death and disease" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Mariuz Karbowski (University of Maryland)
"Identification of a novel E3 ubiquitin ligase that controls turnover of Bax and apoptosis" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:45 pm | Mauro Degli Esposti (University of Manchester)
"Death by lethal injection in activated T cells" |
6:45 pm - 6:55 pm | Discussion |
6:55 pm - 7:30 pm | KEYNOTE ADDRESS |
6:55 pm - 7:20 pm | J. Marie Hardwick (Johns Hopkins University)
"Mitochondrial dynamics, the long and short of it" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
9:30 pm | Party |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |