SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Past Chair's Lecture and Keynote Address |
| Discussion Leader: Doug Green (St. Jude Children's Research Hospital) |
7:40 pm - 8:20 pm | John Abrams (University of Texas Southwestern Medical Center)
"Repurposing the Death Machine"
|
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Vishva Dixit (Genentech)
"Interplay Between Regulators of Apoptosis and Necroptosis"
|
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Signaling, Survival and Death |
| Discussion Leader: Joan Brugge (Harvard Medical School) |
9:00 am - 9:20 am | Kevin Ryan (The Beatson Institute for Cancer Research)
"p53 Modulates Cytokine Responses to Promote Cell Death"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Andreas Bergmann (University of Massachusetts Medical School)
"Autophagy Regulates Tissue Overgrowth in a Context-Dependent Manner"
|
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Sharad Kumar (University of South Australia)
"How Caspase-2 Might Suppress Tumorigensis?"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Domagoj Vucic (Genentech)
"Targeting XIAP in NOD2 Mediated Inflammatory Diseases"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Nader Yatim (Institut Pasteur)
"Necroptotic Cells Induce Efficient Cross-Priming to Ag-Specific CD8+ T Cells"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Seamus Martin (Trinity College)
"Inflammatory Outcomes of Apoptosis and Necroptosis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mitochondria and Cell Death |
| Discussion Leader: Anthony Letai (Harvard Medical School) |
7:30 pm - 7:50 pm | Marie Hardwick (Johns Hopkins University School of Medicine)
"Bcl-xL and Bax Cooperate to Bend Membranes"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Richard Youle (National Institutes of Health)
"Parkin and Regulation of Mitophagy"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Stephen Tait (Beatson Institute)
"Apoptosis as a Tumor Promoter: Failure to Execute Cell Death Leads to DNA Damage and Genomic Instability"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Andreas Strasser (The Walter and Eliza Hall Institute of Medical Research)
"Control of Cell Deletion During Embryogenesis - Apoptosis, Necroptosis or Something Else?" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Apoptotic Linchpins |
| Discussion Leader: Domagoj Vucic (Genentech) |
9:00 am - 9:20 am | Pascal Meier (Institute of Cancer Research)
"The Ripoptosome as Molecular Timer and Mitotic Checkpoint"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Marion MacFarlane (MRC Toxicology Unit)
"The FLIP Side of the DISC: New Insights into c-FLIP Regulation of Caspase-8"
|
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Jerry Chipuk (Mount Sinai)
"Outer Mitochondrial Membrane Shape Engages BAX a9 to Initiate Terminal Unfolded Protein Responses"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Sandra Zinkel (Vanderbilt University)
"BID as a Central Regulator of Cell Death Fates in Hematopoiesis to Preserve Hematopoietic Homeostasis and Stem Cell Function"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Xin Huang (Amgen Inc.)
"Structural Basis for the Cooperative Anti-Tumor Activity of Apo2L/TRAIL and the Death Receptor 5(DR5) Agonist Antibody Conatumumab"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Guy Salvesen (Sanford-Burnham Medical Research Institute)
"Netosis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Clearance of Dying Cells |
| Discussion Leader: John Abrams (University of Texas Southwestern Medical Center) |
7:30 pm - 7:50 pm | Shige Nagata (Kyoto University)
"Exposure of Phosphatidylserine and Engulfment of Apoptotic Cells" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Lin Lin (University of Massachusetts Medical School)
"Complement Factor Mcr Regulates Autophagy in a Non-Cell-Autonomous Manner"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Francesca Peri (European Molecular Biology Laboratory)
"Neuronal Cell Death Goes Live: How Do Microglia Collect the Dying Neurons?"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Will Wood (University of Bath)
"Inflammatory Decisions in Damage and Death"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Survival and Death in Cancer |
| Discussion Leader: Huseyin Mehmet (Merck Research Laboratories) |
9:00 am - 9:20 am | Marcus Peter (Northwestern University)
"Death Induced by CD95/CD95L Elimination (DICE) Preferentially Targets Cancer Stem Cells"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Joan Brugge (Harvard Medical School)
"Microenvironment Influences on Cell Survival in Cancer"
|
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Ricky Johnstone (Peter MacCallum Cancer Centre)
"Advancing Cancer Treatment by Identifying and Targeting Critical Tumor Cell Survival Pathways"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Silvia von Karstedt (University College London)
"KRAS-Driven Cancer Progression, Invasion and Metastasis Require Constitutive Endogenous TRAIL/TRAIL-R2 Signaling"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Gerry Melino (University of Rome)
"p53 Family Members in Stem Cell Maintenance and Cancer"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Anthony Letai (Harvard Medical School)
"Precision Cancer Therapy with BH3 Profiling" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Cell Survival and Death in the Nervous System |
| Discussion Leader: Marie Hardwick (Johns Hopkins University School of Medicine) |
7:30 pm - 7:50 pm | Phil Barker (McGill University)
"Caspase Regulation in Axonal Degeneration and Synaptic Plasticity"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Cheng-Yu Lee (University of Michigan)
"Regulation of Neural Stem Cell Survival by Suppressing Necrosis"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Beth Stevens (Harvard Medical School)
"Glia, Immune Signaling and Synapse Clearance"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Marc Freeman (HHMI/ University of Massachusetts Medical School)
"Molecular Pathways Promoting Axon Degeneration" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Non-Apoptotic Death Pathways |
| Discussion Leader: Guy Salvesen (Sanford-Burnham Medical Research Institute) |
9:00 am - 9:20 am | Junying Yuan (Harvard Medical School)
"Necroptosis in Human Diseases"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Andreas Linkermann (Christian Albrechts University)
"Regulated Necrosis in Acute Kidney Injury"
|
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | William Kasier (Emory University)
"Balancing RIP1, RIP3 and Caspase 8 Activities in Mammalian Development, Inflammation and Host Defense"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Zhirong Shen (National Institute of Biological Sciences)
"Novel Regulators of Programmed Necrosis"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Christine Watson (University of Cambridge)
"Stat3 Coordinately Regulates and Exploits the Lysosomal System to Control Cell Death In Vivo"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Michael Overholtzer (Memorial Sloan-Kettering Cancer Center)
"Death by Engulfment" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Programmed Necrosis and Inflammation |
| Discussion Leader: Junying Yuan (Harvard Medical School) |
7:30 pm - 7:50 pm | Francis Chan (University of Massachusetts Medical School)
"Rising from the Grave: How RIP3 Promotes Inflammation"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | John Silke (The Walter and Eliza Hall Institute of Medical Research)
"IAPs, Necroptosis, Auto-Inflammatory Diseases and Cancer: Exciting Therapeutic Opportunities"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Pete Gough (Glaxo Smith Kline)
"Therapeutic Targeting of RIP1 Kinase and Necroptosis"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Doug Green (St. Jude Children's Research Hospital)
"Lapping Up Death: How Non Canonical Autophagy Controls the Consequences of Cell Death?" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |