| Sunday |
| 4:00 pm - 8:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Session: Perspectives on Cell Death and Survival |
| Discussion Leader: Henning Walczak (UCL Cancer Institute, United Kingdom) |
| 7:40 pm - 7:45 pm | Introduction by Discussion Leader |
| 7:45 pm - 8:20 pm | Eric Baehrecke (University of Massachusetts Medical School, USA)
"Autophagy, Cell Health and Cell Death" |
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:40 pm | Introduction by Discussion Leader |
| 8:40 pm - 9:15 pm | Douglas Green (St. Jude Children's Research Hospital, USA)
"Death and Undeath: To the Edge of Necroptosis
and Back" |
| 9:15 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Signalling,
Survival and Death |
| Discussion Leader: Marion MacFarlane (Medical Research Council Toxicology Unit, United Kingdom) |
| 9:00 am - 9:15 am | Vishva Dixit (Genentech, Inc., USA)
"Cell Death in Inflammation" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Selected from Poster Abstracts: Hamsa Puthalakath (La Trobe University, Australia)
"Identification of a Novel Death Receptor (FUMR) Responsible for Immune Cell Death During Sepsis" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Seamus Martin (Trinity College Dublin, Ireland)
"Exploring the Interface Between Cell Death and Inflammation" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Pascal Meier (The Institute of Cancer Research, United Kingdom)
"Ubiquitin-Dependent Regulation of TNF-Induced Cell Death" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Selected from Poster Abstracts: Sebastian Kupka (University College London, United Kingdom)
"LUBAC and LUBAC-Associated Proteins in Cell Death and Inflammation" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:10 am | Coffee Break |
| 11:10 am - 11:25 am | Hao Wu (Harvard Medical School / Boston Children's Hospital, USA)
"Molecular Elucidation of Inflammasome Activation and Regulation" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Selected from Poster Abstracts: Astrid Fauster (CeMM Research Center for Molecular Medicine, Austrian Academy of Sciences, Austria)
"A Combined Chemical, Proteomic and Genetic Approach Identifies Novel Inhibitors and Targets for TNF-Induced Necroptosis" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Selected from Poster Abstracts: Matous Hrdinka (University of Oxford, United Kingdom)
"RIPK2 Active Conformation, but Not Its Kinase Activity, Is Essential for Pro-Inflammatory Signalling" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Domagoj Vucic (Genentech, Inc., USA)
"Regulation of Inflammatory and Cell Death Signaling by RIP Kinases" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Marion MacFarlane (Medical Research Council Toxicology Unit, United Kingdom) |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Mitochondria and
Cell Death in Cancer |
| Discussion Leader: Andreas Strasser (Walter and Eliza Hall Institute of Medical Research, Australia) |
| 6:00 pm - 6:15 pm | Joseph Opferman (St. Jude Children's Research Hospital, USA)
"Revealing MCL-1's Role(s) During Differentiation" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:35 pm | Selected from Poster Abstracts: Andrew Gilmore (Wellcome Trust Centre for Cell/Matrix Research, United Kingdom)
"Differential Binding Between BH3-Only and Anti-Apoptotic Bcl-2 Proteins Monitored by Protein Dynamics in Live Imaging Shows Single Cell Heterogeneity in Apoptotic Priming" |
| 6:35 pm - 6:40 pm | Discussion |
| 6:40 pm - 6:55 pm | Selected from Poster Abstracts: Kelvin Cain (MRC Toxicology Unit, United Kingdom)
"Bioenergetic Reprogramming Induces Profound Changes in the Mitochondrial Proteome, 3D Mitochondrial Structure and Proteins that Regulate Death" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:15 pm | Selected from Poster Abstracts: Grant Dewson (Walter and Eliza Hall Institute of Medical Research, Australia)
"VDAC2 Is a Critical Promoter of Bax Apoptotic Function" |
| 7:15 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:35 pm | Ana Garcia-Saez (University of Tübingen, Germany)
"Bax Pores, One Particle at a Time" |
| 7:35 pm - 7:40 pm | Discussion |
| 7:40 pm - 7:55 pm | Selected from Poster Abstracts: Evripidis Gavathiotis (Albert Einstein College of Medicine, USA)
"Structural and Functional Insights into the Regulation of Bax Activation" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Mitochondria and
Cell Death in Neurodegeneration and Autoimmunity |
| Discussion Leader: Douglas Green (St. Jude Children's Research Hospital, USA) |
| 9:00 am - 9:15 am | Danielle Sliter (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Mitochondria, Autophagy and Ubiquitin Phosphorylation" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Selected from Poster Abstracts: Frank Edlich (University of Freiburg, Germany)
"Parkin Promotes Proteasomal Degradation of Misregulated Bax" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | J. Marie Hardwick (Johns Hopkins University, USA)
"Alternate Functions of BCL-xL and BAX" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Selected from Poster Abstracts: Solange Desagher (CNRS, France)
"Characterization of a Novel Pathway Regulating α-Synuclein Expression and Neuronal Death in Parkinson's Disease" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Selected from Poster Abstracts: Lian Li (Emory University School of Medicine, USA)
"PINK1-Mediated Mitochondrial Signaling Against Neurodegeneration" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:10 am | Coffee Break |
| 11:10 am - 11:25 am | Atan Gross (Weizmann Institute of Science, Israel)
"Mitochondria Metabolism at the Crossroads of Life and Death" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Selected from Poster Abstracts: Stephen Tait (Beatson Institute, Cancer Research UK, United Kingdom)
"Targeting Cancer by Inhibiting Apoptosis" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Selected from Poster Abstracts: Juan Sanchez (Imperial College London, United Kingdom)
"Mitochondrial Dynamics Regulate the Apoptotic Threshold During the Onset of Embryonic Differentiation" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Nika Danial (Harvard Medical School, USA)
"Metabolic Control of Beta-Cell Survival" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Cell Death
Networks and Clearance |
| Discussion Leader: John Abrams (University of Texas Southwestern Medical Center, USA) |
| 6:00 pm - 6:15 pm | Shigekazu Nagata (Osaka University, Japan)
"Molecular Mechanism of Apoptotic Phosphatidylserine Exposure" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:35 pm | Selected from Poster Abstracts: Barbara Conradt (Ludwig Maximilians University of Munich, Germany)
"How Do C. elegans Engulfment Pathways Promote Apoptosis?" |
| 6:35 pm - 6:40 pm | Discussion |
| 6:40 pm - 6:55 pm | Inna Lavrik (Otto-von-Guericke University Magdeburg, Germany)
"Molecular Crosstalk of CD95 and TNFR1 Signaling Networks" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:15 pm | Guy Salvesen (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Proteolytic Cross-Talk in Cell Death Networks" |
| 7:15 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:35 pm | Will Wood (University of Bristol, United Kingdom)
"Detecting Death and Damage in Drosophila" |
| 7:35 pm - 7:40 pm | Discussion |
| 7:40 pm - 7:55 pm | Selected from Poster Abstracts: Francesco Dazzi (King's College London, United Kingdom)
"Mesenchymal Stromal Cell Apoptosis in Graft-Versus-Host Disease" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Survival
and Death in Cancer |
| Discussion Leader: Atan Gross (Weizmann Institute of Science, Israel) |
| 9:00 am - 9:15 am | Marcus Peter (Northwestern University, USA)
"Killing Cancer Cells by DICE" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Selected from Poster Abstracts: Dagmar Kulms (Experimental Dermatology, Germany)
"Caspase-8 Promotes Uncontrolled Progression of Cancer Cells" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Selected from Poster Abstracts: Gemma Kelly (Walter and Eliza Hall Institute of Medical Research, Australia)
"Investigating the Impact of TP53 Mutations/Loss on the Potential of MCL-1 Targeting for MYC-Driven Lymphoma Therapy" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Selected from Poster Abstracts: Mads Daugaard (University of British Columbia, Canada)
"Glycosaminoglycans as Novel Cancer Targets" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Selected from Poster Abstracts: Gerry Melino (Medical Research Council, United Kingdom)
"The E3 Ubiquitin Ligase WWP1 Sustains the Growth of Acute Myeloid Leukemia" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:10 am | Coffee Break |
| 11:10 am - 11:25 am | Andreas Villunger (Medical University of Innsbruck, Austria)
"Caspase-2, Enigma No More" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Selected from Poster Abstracts: Delphine Merino (Walter and Eliza Hall Institute of Medical Research, Australia)
"Breast Cancer and Metastasis: New Insights into Cell Death Pathways" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Selected from Poster Abstracts: Kirill Rosen (Dalhousie University, Canada)
"ErbB2 as a Regulator of Cancer Cell Survival" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Selected from Poster Abstracts: Julian Pardo (University of Zaragoza, Spain)
"The Dual Role of Inflammatory and Apoptotic Granzymes During Colorectal Carcinoma Development" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Non-Canonical
Death Pathways and Model Organisms |
| Discussion Leader: Eric Baehrecke (University of Massachusetts Medical School, USA) |
| 6:00 pm - 6:15 pm | Christine Watson (University of Cambridge, United Kingdom)
"Non-Apoptotic Cell Death in Mammary Epithelial Cells" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:35 pm | Selected from Poster Abstracts: Michelle Riegman (Memorial Sloan Kettering Cancer Center, USA)
"Ferroptotic Cell Death Has Non-Cell-Autonomous Properties" |
| 6:35 pm - 6:40 pm | Discussion |
| 6:40 pm - 6:55 pm | John Abrams (University of Texas Southwestern Medical Center, USA)
"Death and 'Transposopathy'" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:15 pm | Selected from Poster Abstracts: Rebekah Kells (University of Edinburgh, United Kingdom)
"Environmental Stress-Related 'Stem-Ness' in Aggressive B Cell Lymphoma" |
| 7:15 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:35 pm | Sharad Kumar (University of South Australia, Australia)
"Regulation of Autophagy-Dependent Midgut Degradation in Drosophila" |
| 7:35 pm - 7:40 pm | Discussion |
| 7:40 pm - 7:55 pm | Scott Lowe (Memorial Sloan Kettering Cancer Center, USA)
"Tumor Suppressor and Tumor Maintenance Genes" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 9:00 am - 12:30 pm | Programmed
Necrosis and Inflammation |
| Discussion Leader: Guy Salvesen (Sanford Burnham Prebys Medical Discovery Institute, USA) |
| 9:00 am - 9:15 am | Kim Newton (Genentech, Inc., USA)
"Exploring the Pro-Survival Function of RIPK1" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Selected from Poster Abstracts: Ben Croker (Boston Children's Hospital, USA)
"Effector Functions of Necroptosis" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Peter Vandenabeele (VIB, University of Ghent, Belgium)
"Role of RIPK3 in Cell Death and Inflammation" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Junying Yuan (Harvard Medical School, USA)
"The Role of RIPK1 in Necroptosis and Inflammation" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Selected from Poster Abstracts: Andrew Oberst (University of Washington, USA)
"RIPK3 Coordinates Neuroinflammatory Defense Against Viral Infection Independent of Necroptosis" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:10 am | Coffee Break |
| 11:10 am - 11:25 am | Francis Chan (University of Massachusetts Medical School, USA)
"Targeted Strike: Compartmentalized Function of RIPK3 in Inflammation" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Selected from Poster Abstracts: Diego Rodriguez (St. Jude Children's Research Hospital, USA)
"Non-Canonical Activation of Necroptosis: MLKL-Dependent Cell Death in Absence of RIPK3" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Manolis Pasparakis (University of Cologne, Germany)
"RIPK1 in Cell Death and Inflammation" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | John Silke (Walter and Eliza Hall Institute of Medical Research, Australia)
"Cell Death and Inflammation in the Skin" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Translating Cell Death Discoveries Towards the Clinic |
| Discussion Leader: J. Marie Hardwick (Johns Hopkins University, USA) |
| 6:00 pm - 6:15 pm | Kristopher Sarosiek (Harvard T.H. Chan School of Public Health, USA)
"Dynamic Regulation of Apoptosis in Healthy Tissues" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:35 pm | Selected from Poster Abstracts: Andreas Linkermann (University of Kiel, Germany)
"MLKL Mediates Necroptosis in Humans" |
| 6:35 pm - 6:40 pm | Discussion |
| 6:40 pm - 6:55 pm | Selected from Poster Abstracts: Maria Guicciardi (Mayo Clinic, USA)
"A Novel Murine Model of SMAC Mimetic-Induced Acute Sclerosing Cholangitis" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:15 pm | Selected from Poster Abstracts: Loren Walensky (Dana-Farber Cancer Institute, USA)
"Translating Pro-Apoptotic Peptide Helices to the Clinic" |
| 7:15 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:35 pm | Sandra Zinkel (Vanderbilt University School of Medicine, USA)
"Regulation of Cell Death Decisions in Hematopoietic Differentiation and Stem Cell Function" |
| 7:35 pm - 7:40 pm | Discussion |
| 7:40 pm - 7:55 pm | Andreas Strasser (Walter and Eliza Hall Institute of Medical Research, Australia)
"Life Without Intrinsic Apoptosis: Consequences of Embryonic Development in the Combined Absence of BAX, BAK and BOK" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
