Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Perspectives on Cell Death and Disease
Discussion Leader: Marion MacFarlane (MRC Toxicology Unit, University of Cambridge, United Kingdom)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:20 pm
Henning Walczak (University College London, United Kingdom)
"Cell Death and Ubiquitin in Inflammation and Cancer"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 8:40 pm
Introduction by Discussion Leader
8:40 pm - 9:15 pm
Andreas Strasser (Walter and Eliza Hall Institute of Medical Research, Australia)
"The Roles of Different Forms of Cell Death in Cancer"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Peering into the Molecular Machines that Regulate Cell Death and Inflammation
Discussion Leader: Francis Chan (Duke University Medical Center, USA)
9:00 am - 9:20 am
Douglas Green (St. Jude Children's Research Hospital, USA)
"LC3-Associated Phagocytosis and Inflammation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
Selected from Poster Abstracts: Edward Miao (University of North Carolina at Chapel Hill, USA)
"Infectious Models Reveal a Unique Role for Caspase-7 After Cytotoxic Lymphocyte Attack"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Selected from Poster Abstracts: Zheng Zhou (Baylor College of Medicine, USA)
"Autophagosomes Play an Important Role in the Clearance of Apoptotic Cells"
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
Hao Wu (Harvard Medical School / Boston Children's Hospital, USA)
"Structures and Functions of Gasdermins in Lytic Cell Death and Cytokine Secretion"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Selected from Poster Abstracts: Yaron Fuchs (Technion - Israel Institute of Technology, Israel)
"Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
Mads Gyrd-Hansen (Ludwig Institute for Cancer Research, University of Oxford, United Kingdom)
"Ubiquitin-Mediated Regulation of NOD2 Signalling"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Robert Means (Yale University School of Medicine, USA)
"Regulation of Antiviral Responses by the BCL-2 Family Member Bok"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Kelvin Cain (MRC Toxicology Unit, University of Cambridge, United Kingdom)
"The Interplay Between Autophagy and Cellular Bioenergetics Mediates Tumour Cell Resistance to BH3-Mimetics"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Living a Double Life: Death Receptors and Their Functions Beyond Cell Death
Discussion Leader: Henning Walczak (University College London, United Kingdom)
7:30 pm - 7:50 pm
Seamus Martin (Trinity College Dublin, Ireland)
"How Is Stress-Induced Inflammation Sensed and Signaled?"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Selected from Poster Abstracts: Masayuki Yamashita (Columbia University, USA)
"TNFα Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Marcus Peter (Northwestern University, USA)
"CD95L mRNA Is Toxic to Cells"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Selected from Poster Abstracts: Diana Panayotova-Dimitrova (University Hospital Aachen, RWTH Aachen University, Germany)
"cFLIP Isoforms Regulate Apoptosis/Necroptosis Decision in Keratinocytes In Vivo "
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Pascal Meier (The Institute of Cancer Research, London, United Kingdom)
"Death by Altruism"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Command Center: How the Mitochondrion Controls Life and Death Decisions
Discussion Leader: Douglas Green (St. Jude Children's Research Hospital, USA)
9:00 am - 9:20 am
Ruth Kluck (Walter and Eliza Hall Institute of Medical Research, Australia)
"Regulating Bak and Bax Upstream of Dimer Formation"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Selected from Poster Abstracts: Jerry Adams (The Walter and Eliza Hall Institute of Medical Research, Australia)
"BAX Activation: Mutants in Its Non-Canonical BH3 Binding Site Reveal Allosteric Changes and Conformers Controlling Mitochondrial Association"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Stephen Tait (Cancer Research UK Beatson Institute, United Kingdom)
"How MOMP, via MIMP, Gets to STING"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Danielle Sliter (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Mitophagy Mitigates STING-Mediated Inflammation"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Ana Garcia-Saez (University of Tübingen, Germany)
"Molecular Mechanism of Bax and Bak at the Single Molecule Level: Spot the Difference"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Selected from Poster Abstracts: Stephanie Berger (University of Washington, USA)
"Potent and Selective Designed Protein Inhibitors of Pro-Apoptotic Bak and Bax"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Selected from Poster Abstracts: Kristopher Sarosiek (Harvard T.H. Chan School of Public Health, USA)
"Dynamic Regulation of Apoptosis as a Driver of Treatment-Associated Toxicities"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Selected from Poster Abstracts: Daniel Gray (The Walter and Eliza Hall Institute, Australia)
"Mass Cytometric Analysis of Life and Death Decisions in Blood Cancer (Cells)"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Lisa Drew (AstraZeneca R&D Boston, USA)
"Targeting Bcl-2 Family Members for the Treatment of Hematological and Solid Tumors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
View from Another World: Non-Primate Models of Cell Death
Discussion Leader: J. Marie Hardwick (Johns Hopkins University, USA)
7:30 pm - 7:50 pm
Barbara Conradt (Ludwig Maximilian University of Munich, Germany)
"Gene Expression: Its Role in the Control of Apoptotic Cell Death During C. elegans Development"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Selected from Poster Abstracts: Selena Romero (University of North Carolina at Chapel Hill, USA)
"Dynamics of BH-3-Only Transcription and Translation in Axon Pruning and Apoptosis"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
John Abrams (University of Texas Southwestern Medical Center, USA)
"Death, Cancer and the Game of Transposons"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Selected from Poster Abstracts: Piya Ghose (The Rockefeller University, USA)
"EFF-1 Fusogen Promotes Phagosome Sealing During Cell Process Clearance in Caenorhabditis elegans "
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Eric Baehrecke (University of Massachusetts Medical School, USA)
"Discovery of New Regulators of Autophagy in Dying Cells"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Many Faces of RIP Kinases in Pathological and Normal Physiology
Discussion Leader: Andreas Strasser (Walter and Eliza Hall Institute of Medical Research, Australia)
9:00 am - 9:20 am
Junying Yuan (Harvard Medical School, USA)
"Regulation of RIPK1 Activation by Ubiquitination and Phosphorylation"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Selected from Poster Abstracts: Dieter Adam (Institute of Immunology, University of Kiel, Germany)
"The Enhanced Susceptibility of ADAM-17 Hypomorphic Mice to DSS-Induced Colitis Is Not Ameliorated by Loss of RIPK3, Revealing an Unexpected Function of ADAM-17 in Necroptosis"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Kim Newton (Genentech Inc., USA)
"Regulation of RIPK1 Activation"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
Selected from Poster Abstracts: Shin Murai (Toho University School of Medicine, Japan)
"A Novel FRET Biosensor for Necroptosis Uncovers Two Different Modes of the Release of DAMPs"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Domagoj Vucic (Genentech, Inc., USA)
"Regulation of Inflammatory Cell Death Signaling by RIP Kinases"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Matija Zelic (Sanofi, USA)
"Modulating Microglial Phenotypes via Inhibition of RIPK1 Activation or Growth Signaling for Therapeutic Benefit in Neuroinflammation and Multiple Sclerosis"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts: Ben Croker (Boston Children's Hospital, USA)
"PAD4 Negatively Regulates Neutrophil Necroptosis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Melanie Fritsch (University Hospital Cologne, Germany)
"Caspase-8 Enzymatic Activity Is Required to Counteract Cellular Inflammatory Signalling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Kartik Gupta (University of Wisconsin-Madison, USA)
"Polo-Like Kinase1 (PLK1)-Mediated Phosphorylation of RIP3 Sensitizes Cells to Necroptosis During G2/M Phase of Cell Cycle"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Atypical Forms of Cell Death
Discussion Leader: Eric Baehrecke (University of Massachusetts Medical School, USA)
7:30 pm - 7:50 pm
J. Marie Hardwick (Johns Hopkins University, USA)
"The Death of Pathogenic Fungi and Extrapolations to Human Disease"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Selected from Poster Abstracts: Michael Lee (University of Massachusetts Medical School, USA)
"Chemical and Genetic Screening Approaches to Identify Mechanisms of Crosstalk Between Death Pathways"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Selected from Poster Abstracts: Scott Dixon (Stanford University, USA)
"Multidrug Resistance Protein 1 Controls a Ferroptosis/Apoptosis Sensitivity Switch"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Christian Mayer (The Rockefeller University, USA)
"The Microanatomic Segregation of Selection by Apoptosis in the Germinal Center"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Clifford Luke (Washington University in St. Louis School of Medicine, USA)
"Primary Lysosomal-Mediated Necrosis Is a Divergent Stress-Induced Regulated Cell Death Pathway Conserved from Worms to Mammals"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Yingfei Wang (University of Texas Southwestern Medical Center, USA)
"A Nuclease Mediates DNA Damage and PARP-1 Dependent Cell Death"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The 'Yin and Yang' of Cell Death Signal Adaptors in Cancer
Discussion Leader: John Abrams (University of Texas Southwestern Medical Center, USA)
9:00 am - 9:20 am
Christine Watson (University of Cambridge, United Kingdom)
"The Yin and Yang of Stat3: The Killer and the Survival Factor"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
Selected from Poster Abstracts: Ivano Amelio (MRC Toxicology Unit, University of Cambridge, United Kingdom)
"p53 Mutants Co-Operate with HIF-1 to Promote Tumour Progression"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Selected from Poster Abstracts: Suzanne Cory (The Walter and Eliza Hall Institute of Medical Research, Australia)
"MYC-Driven Cells Need MNT to Survive"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 10:50 am
Selected from Poster Abstracts: Antonia Policheni (Walter and Eliza Hall Institute of Medical Research, Australia)
"New Hallmarks of Cancer: Defects in Cell Competition and Increased Apoptosis Synergize to Drive T Cell Acute Lymphomatic Leukemia (T-ALL)"
10:50 am - 10:55 am
Discussion
10:55 am - 11:10 am
Selected from Poster Abstracts: Dagmar Kulms (University Hospital Dresden, Germany)
"Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Selected from Poster Abstracts: Dhyan Chandra (Roswell Park Comprehensive Cancer Center, USA)
"Novel Insights on Apoptosome and Mitochondrial Dysfunction in Cancer"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts: Lisa Bouchier-Hayes (Baylor College of Medicine, USA)
"Caspase-2 Regulates S-Phase Checkpoint Activation to Facilitate DNA Repair"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Andreas Villunger (Medical University of Innsbruck, Austria)
"The PIDDosome in Centrosome and Ploidy Surveillance"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Cell Death and Inflammation in Health and Disease
Discussion Leader: Pascal Meier (The Institute of Cancer Research, London, United Kingdom)
5:30 pm - 5:45 pm
Selected from Poster Abstracts: Andrew Oberst (University of Washington, USA)
"Death-Independent Roles of the Necroptotic Pathway in the Restriction of Neuroinvasive Viral Infection"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:10 pm
John Silke (Walter and Eliza Hall Institute of Medical Research, Australia)
"Time for a Break: The Role of RIPK1 Cleavage in Health and Disease"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:30 pm
Selected from Poster Abstracts: Pratyusha Mandal (Emory University, USA)
"Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
Selected from Poster Abstracts: Vijay Rathinam (UConn Health School of Medicine, USA)
"A New Innate Immune Regulatory Role for Gasdermin D"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:15 pm
Shigekazu Nagata (Osaka University, Japan)
"Phosphatidylserine-Dependent Engulfment of Apoptotic Cells by Macrophages"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure