Cell Death Mediators in Normal and Disease Physiology

August 5 - 10, 2018

Chair

Vice Chair

Grand Summit Hotel at Sunday River

97 Summit Road

Newry, Maine, United States

Venue and Travel Information

Conference Description

Many diseases are frequently associated with excessive, reduced or inappropriate cell death. The 2018 Gordon Research Conference on Cell Death will foster unencumbered scientific exchange, focusing on mechanisms that specify cell death in normal development and in various human pathologies. The Conference will accelerate discovery in these areas and will also advance new opportunities for therapeutic intervention in the many diseases that are caused by de-regulated cell death, such as cancer, auto-immune diseases, neurodegeneration and other age-associated disorders. The GRC, together with its first associated Gordon Research Seminar (GRS), will gather established experts who are leaders in the Cell Death field as well as junior scientists, Post-docs and Graduate students to share exciting discoveries and exchange ideas. Some poster presenters will be selected for oral presentations. The intimate format and collegial atmosphere of this Conference is designed to enable brainstorming and promote collaboration.

Related Meeting

This GRC will be held in conjunction with the "Cell Death" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Perspectives on Cell Death and Disease Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:20 pm	"Cell Death and Ubiquitin in Inflammation and Cancer"
8:20 pm - 8:35 pm	Discussion
8:35 pm - 8:40 pm	Introduction by Discussion Leader
8:40 pm - 9:15 pm	"The Roles of Different Forms of Cell Death in Cancer"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Peering into the Molecular Machines that Regulate Cell Death and Inflammation Discussion Leader:
9:00 am - 9:20 am	"LC3-Associated Phagocytosis and Inflammation"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	Selected from Poster Abstracts: "Infectious Models Reveal a Unique Role for Caspase-7 After Cytotoxic Lymphocyte Attack"
9:45 am - 9:50 am	Discussion
9:50 am - 10:05 am	Selected from Poster Abstracts: "Autophagosomes Play an Important Role in the Clearance of Apoptotic Cells"
10:05 am - 10:10 am	Discussion
10:10 am - 10:30 am	"Structures and Functions of Gasdermins in Lytic Cell Death and Cytokine Secretion"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:20 am	Selected from Poster Abstracts: "Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size"
11:20 am - 11:25 am	Discussion
11:25 am - 11:45 am	"Ubiquitin-Mediated Regulation of NOD2 Signalling"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	Selected from Poster Abstracts: "Regulation of Antiviral Responses by the BCL-2 Family Member Bok"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Selected from Poster Abstracts: "The Interplay Between Autophagy and Cellular Bioenergetics Mediates Tumour Cell Resistance to BH3-Mimetics"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Living a Double Life: Death Receptors and Their Functions Beyond Cell Death Discussion Leader:
7:30 pm - 7:50 pm	"How Is Stress-Induced Inflammation Sensed and Signaled?"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:10 pm	Selected from Poster Abstracts: "TNFα Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"CD95L mRNA Is Toxic to Cells"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:55 pm	Selected from Poster Abstracts: "cFLIP Isoforms Regulate Apoptosis/Necroptosis Decision in Keratinocytes In Vivo"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Death by Altruism"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The Command Center: How the Mitochondrion Controls Life and Death Decisions Discussion Leader:
9:00 am - 9:20 am	"Regulating Bak and Bax Upstream of Dimer Formation"
9:20 am - 9:25 am	Discussion
9:25 am - 9:40 am	Selected from Poster Abstracts: "BAX Activation: Mutants in Its Non-Canonical BH3 Binding Site Reveal Allosteric Changes and Conformers Controlling Mitochondrial Association"
9:40 am - 9:45 am	Discussion
9:45 am - 10:05 am	"How MOMP, via MIMP, Gets to STING"
10:05 am - 10:10 am	Discussion
10:10 am - 10:20 am	Selected from Poster Abstracts: "Mitophagy Mitigates STING-Mediated Inflammation"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Molecular Mechanism of Bax and Bak at the Single Molecule Level: Spot the Difference"
11:15 am - 11:20 am	Discussion
11:20 am - 11:30 am	Selected from Poster Abstracts: "Potent and Selective Designed Protein Inhibitors of Pro-Apoptotic Bak and Bax"
11:30 am - 11:35 am	Discussion
11:35 am - 11:45 am	Selected from Poster Abstracts: "Dynamic Regulation of Apoptosis as a Driver of Treatment-Associated Toxicities"
11:45 am - 11:50 am	Discussion
11:50 am - 12:00 pm	Selected from Poster Abstracts: "Mass Cytometric Analysis of Life and Death Decisions in Blood Cancer (Cells)"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:25 pm	"Targeting Bcl-2 Family Members for the Treatment of Hematological and Solid Tumors"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	View from Another World: Non-Primate Models of Cell Death Discussion Leader:
7:30 pm - 7:50 pm	"Gene Expression: Its Role in the Control of Apoptotic Cell Death During C. elegans Development"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:10 pm	Selected from Poster Abstracts: "Dynamics of BH-3-Only Transcription and Translation in Axon Pruning and Apoptosis"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Death, Cancer and the Game of Transposons"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:55 pm	Selected from Poster Abstracts: "EFF-1 Fusogen Promotes Phagosome Sealing During Cell Process Clearance in Caenorhabditis elegans"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Discovery of New Regulators of Autophagy in Dying Cells"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	The Many Faces of RIP Kinases in Pathological and Normal Physiology Discussion Leader:
9:00 am - 9:20 am	"Regulation of RIPK1 Activation by Ubiquitination and Phosphorylation"
9:20 am - 9:25 am	Discussion
9:25 am - 9:40 am	Selected from Poster Abstracts: "The Enhanced Susceptibility of ADAM-17 Hypomorphic Mice to DSS-Induced Colitis Is Not Ameliorated by Loss of RIPK3, Revealing an Unexpected Function of ADAM-17 in Necroptosis"
9:40 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Regulation of RIPK1 Activation"
10:05 am - 10:10 am	Discussion
10:10 am - 10:25 am	Selected from Poster Abstracts: "A Novel FRET Biosensor for Necroptosis Uncovers Two Different Modes of the Release of DAMPs"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Regulation of Inflammatory Cell Death Signaling by RIP Kinases"
11:20 am - 11:25 am	Discussion
11:25 am - 11:35 am	Selected from Poster Abstracts: "Modulating Microglial Phenotypes via Inhibition of RIPK1 Activation or Growth Signaling for Therapeutic Benefit in Neuroinflammation and Multiple Sclerosis"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	Selected from Poster Abstracts: "PAD4 Negatively Regulates Neutrophil Necroptosis"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Selected from Poster Abstracts: "Caspase-8 Enzymatic Activity Is Required to Counteract Cellular Inflammatory Signalling"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: "Polo-Like Kinase1 (PLK1)-Mediated Phosphorylation of RIP3 Sensitizes Cells to Necroptosis During G2/M Phase of Cell Cycle"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Atypical Forms of Cell Death Discussion Leader:
7:30 pm - 7:50 pm	"The Death of Pathogenic Fungi and Extrapolations to Human Disease"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:10 pm	Selected from Poster Abstracts: "Chemical and Genetic Screening Approaches to Identify Mechanisms of Crosstalk Between Death Pathways"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:30 pm	Selected from Poster Abstracts: "Multidrug Resistance Protein 1 Controls a Ferroptosis/Apoptosis Sensitivity Switch"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"The Microanatomic Segregation of Selection by Apoptosis in the Germinal Center"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Selected from Poster Abstracts: "Primary Lysosomal-Mediated Necrosis Is a Divergent Stress-Induced Regulated Cell Death Pathway Conserved from Worms to Mammals"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Selected from Poster Abstracts: "A Nuclease Mediates DNA Damage and PARP-1 Dependent Cell Death"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The 'Yin and Yang' of Cell Death Signal Adaptors in Cancer Discussion Leader:
9:00 am - 9:20 am	"The Yin and Yang of Stat3: The Killer and the Survival Factor"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	Selected from Poster Abstracts: "p53 Mutants Co-Operate with HIF-1 to Promote Tumour Progression"
9:45 am - 9:50 am	Discussion
9:50 am - 10:05 am	Selected from Poster Abstracts: "MYC-Driven Cells Need MNT to Survive"
10:05 am - 10:10 am	Discussion
10:10 am - 10:40 am	Coffee Break
10:40 am - 10:50 am	Selected from Poster Abstracts: "New Hallmarks of Cancer: Defects in Cell Competition and Increased Apoptosis Synergize to Drive T Cell Acute Lymphomatic Leukemia (T-ALL)"
10:50 am - 10:55 am	Discussion
10:55 am - 11:10 am	Selected from Poster Abstracts: "Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	Selected from Poster Abstracts: "Novel Insights on Apoptosome and Mitochondrial Dysfunction in Cancer"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	Selected from Poster Abstracts: "Caspase-2 Regulates S-Phase Checkpoint Activation to Facilitate DNA Repair"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"The PIDDosome in Centrosome and Ploidy Surveillance"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Cell Death and Inflammation in Health and Disease Discussion Leader:
5:30 pm - 5:45 pm	Selected from Poster Abstracts: "Death-Independent Roles of the Necroptotic Pathway in the Restriction of Neuroinvasive Viral Infection"
5:45 pm - 5:50 pm	Discussion
5:50 pm - 6:10 pm	"Time for a Break: The Role of RIPK1 Cleavage in Health and Disease"
6:10 pm - 6:15 pm	Discussion
6:15 pm - 6:30 pm	Selected from Poster Abstracts: "Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock"
6:30 pm - 6:35 pm	Discussion
6:35 pm - 6:50 pm	Selected from Poster Abstracts: "A New Innate Immune Regulatory Role for Gasdermin D"
6:50 pm - 6:55 pm	Discussion
6:55 pm - 7:15 pm	"Phosphatidylserine-Dependent Engulfment of Apoptotic Cells by Macrophages"
7:15 pm - 7:20 pm	Discussion
7:20 pm - 7:30 pm	Closing Remarks
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R13CA232392. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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