Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Perspectives on the Mechanism and Function of Cell Death in Physiology
Discussion Leaders: Pascal Meier (The Institute of Cancer Research, London, United Kingdom)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
Vishva Dixit (Genentech, Inc., United States)
"Cell Rupture in Dying Cells - How Does It Actually Happen?"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Marion MacFarlane (MRC Toxicology Unit, University of Cambridge, United Kingdom)
"Assembly and Regulation Mechanisms of FADD:Caspase-8-Containing Signalling Complexes"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammation and Tissue Homeostasis
Discussion Leader: Andrew Oberst (University of Washington, United States)
9:00 am - 9:20 am
John Silke (Walter and Eliza Hall Institute of Medical Research, Australia)
"Death in the Arvo - The Strange Tale of RIPK1 in AML"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Manolis Pasparakis (University of Cologne, Germany)
"ZBP1 and Its Role in Cell Death and Inflammation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Andreas Villunger (Medical University of Innsbruck, Austria)
"Redefining Mitotic Catastrophe"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Ben Croker (UC San Diego, United States)
"Neutrophil Funeral Planning or Life After Death?"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Mordecahy Gerlic (Tel Aviv university, Israel)
"The Trojan Horse: T6SS Effectors Induce Pyroptosis within the Phagosome"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Mauro Piacentini (University of Rome Tor Vergata, Italy)
"The STING/TBK1/IRF3/INF Type I Pathway is Defective in Cystic Fibrosis: A New Therapeutic Target for Bacterial Infections"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yi-Nan Gong (Hillman Cancer Center, United States)
"There is a Crack: Plasma Membrane Integrity Sensing and Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Elizabeth Lieschke (The Walter and Eliza Hall institute, Australia)
"Novel Switchable Mutant p53 Mouse Strains to Investigate p53 Gain-of-Function Effects in Tumours"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Marion MacFarlane (MRC Toxicology Unit, University of Cambridge, United Kingdom)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Immunogenic Cell Death
Discussion Leader: Dimitry Ofengeim (Sanofi, United States)
6:00 pm - 6:20 pm
Carla Rothlin (Yale University, United States)
"Principles of Resolving and Non-Resolving Inflammation"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Peter Vandenabeele (VIB-UGent, Belgium)
"Dying in a World Full of Oxygen and Iron: Immunogenic Cell Death and Ferroptosis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Julie Magarian Blander (Weill Cornell Medicine, United States)
"Vita-PAMPs in Noncanonical Inflammasome Activation and Pyroptosis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Petr Broz (Department of Biochemistry, University of Lausanne, Switzerland)
"Pyroptosis, a Lytic Cell Death Coordinating Host Defense and Inflammation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fundamental Mechanisms of Cell Death
Discussion Leader: Carla Rothlin (Yale University, United States)
9:00 am - 9:20 am
J. Marie Hardwick (Johns Hopkins University, United States)
"A Vesicle Trafficking Cell Death Pathway Leads to Vacuole/Lysosome Membrane Permeabilization"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ana Garcia-Saez (University of Cologne, Germany)
"Illuminating Mitochondrial Permeabilization in Apoptosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Inna Lavrik (Otto-von-Guericke University Magdeburg, Germany)
"Targeting c-FLIP in Extrinsic Apoptotic Network"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Joanne Hildebrand (The Walter and Eliza Hall Institute of Medical Research, Australia)
"MLKL Polymorphs Among Us - Evolutionary Winners or Losers?"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
W. Wei-Lynn Wong (University of Zurich, Switzerland)
"TNFR2, Type I IFN and Cytokine Storms"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
Gerry Melino (University of Rome Tor Vergata, Italy)
"The Role of p63 in the Female Germline Fidelity"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Shuai Huang (The Walter & Eliza Hall Institute of Medical Research, Australia)
"Mitochondrial E3 Ubiquitin Ligase MARCHF5 Controls BAK Function Independently of BH3-Only Proteins"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Shruti Bhatt (National University of Singapore, Singapore)
"Evolution in Mitochondrial Apoptotic Priming Drives Resistance to Leukemia Therapy"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Keith Syson Chan (Cedars Sinai Medical Center, United States)
"Cell Death-Induced “Danger” Signals in Modulating the Local TME and Bone Marrow Microenvironment"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cell Death in Neuroinflammation and Neurological disorders
Discussion Leader: Stephen Tait (Cancer Research UK Beatson Institute, United Kingdom)
6:00 pm - 6:20 pm
Marc Freeman (Oregon Health & Science University, United States)
"dSarm/SARM1 Signaling in the Injured Nervous System"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Junying Yuan (Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, China)
"RIPK1 in Human Disease"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Mohanish Deshmukh (University of North Carolina, United States)
"Unexpected Function of the Inflammasomes in Axon Pruning"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:40 pm
Dimitry Ofengeim (Sanofi, United States)
"Targeting Disease Progression in the Nervous System at the Interface of Cell Death and Inflammation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Guy Brown (University of Cambridge, United Kingdom)
"Cell Death by Phagocytosis Contributes to Neurodegeneration, Neuroinflammation and Brain Aging"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Death in Immunity
Discussion Leader: Elizabeth Hartland (Hudson Institute of Medical Research, Australia)
9:00 am - 9:20 am
Seamus Martin (Trinity College Dublin, Ireland)
"What Doesn't Kill You, Makes You...Stressed: Exploring the Links Between Cell Stress, Cell Death and Inflammation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Domagoj Vucic (Genentech, United States)
"Regulation of Inflammatory Disease Signaling by RIP Kinases and IAP Proteins"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Kevin Ryan (Cancer Research UK Beatson Institute, United Kingdom)
"Connecting Autophagy and Inflammation to Regulate Programmed Cell Death"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
Alexander Poltorak (Tufts University, United States)
"Activation of the TRIFosome During the Innate Immune Response"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
Lorenzo Galluzzi (Weill Cornell Medical College, United States)
"Mitochondrial Apoptosis Regulates Immune Responses Driven by Radiation Therapy"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Tom Luedde (Uniklinik Düsseldorf, Germany)
"The Role of Necroptotic Immune Responses in Liver Homeostasis and Hepatocarcinogenesis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Muhammet Gulen (EPFL, Switzerland)
"Sensing DNA as a Danger Signal via the cGAS-STING Pathway"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Zachary Schafer (University of Notre Dame, United States)
"Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Non-Apoptotic Forms of Cell Death
Discussion Leader: Ana Garcia-Saez (University of Cologne, Germany)
6:00 pm - 6:20 pm
Marcus Conrad (Helmholtz Munich, Germany)
"Ferroptosis Modulation for the Treatment of Complex Diseases"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Stephen Tait (Cancer Research UK Beatson Institute, United Kingdom)
"Mitochondria as Inflammatory Signalling Platforms in Cell Death and Senescence"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Silvia von Karstedt (University of Cologne, Germany)
"Vulnerabilities and Function of Cell Death Pathways in Small Cell Lung Cancer"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
Tom Vanden Berghe (Antwerp University, Belgium)
"Ferroptosis Targeting: Lifesaving at Intensive Care Units?"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Sjoerd van Wijk (Institute for Experimental Cancer Research in Pediatrics, Goethe University, Germany)
"Dual Roles of USP22 in Necroptosis and IFN-Mediated Cell Fate Signaling in Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Harnessing Cell Death Mechanisms in Cancer
Discussion Leader: Julie Magarian Blander (Weill Cornell Medicine, United States)
9:00 am - 9:20 am
Philipp Jost (Medical University of Graz, Austria)
"Necrosome Signaling and Immune Evasion in Lung Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Andreas Strasser (Walter and Eliza Hall Institute of Medical Research, Australia)
"Which Factors Decide Cell Death Versus Cell Cycle Arrest After p53 Activation?"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Kristopher Sarosiek (Harvard School of Public Health, United States)
"Your Roots Matter: How Apoptosis Regulation in Cell of Origin Drives Broad-Scale Sensitivity or Resistance to Cancer Therapies"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Mads Daugaard (University of British Columbia, Canada)
"A Genome-Wide CRISPR Screen Reveals Death and Survival Pathways that Determine the Response to Cisplatin in Bladder Cancer"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Dagmar Kulms (University Hospital Dresden, Germany)
"Focal Adhesion Kinase Plays a Dual Role in TRAIL Resistance and Metastatic Outgrowth of Malignant Melanoma"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Jin Wang (Baylor College of Medicine, United States)
"A First-in-Class RIPK1 Degrader Sensitizes Immune Checkpoint Blockades by Overcoming Intrinsic Resistance in Cancer Cells and Activating B Cells for Antitumor Immunity"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Irmina García Carpio (Medical University of Innsbruck, Austria)
"Dissecting the Molecular Basis of Sterile Inflammation Upon Centrosome Aberrations"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
A. Justin Rucker (Duke University, United States)
"RIPK1-independent Necroptosis Drives Anti-Tumor Immunity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Lisa Hom (University of Notre Dame, United States)
"A Role for Fibroblast Derived SASP Factors in the Activation of Non-apoptotic Cell Death in Normal Mammary Epithelial Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Infectious Diseases and Cell Death
Discussion Leader: John Silke (Walter and Eliza Hall Institute of Medical Research, Australia)
6:00 pm - 6:20 pm
Elizabeth Hartland (Hudson Institute of Medical Research, Australia)
"Cell Death and Cell Architecture During Bacterial Infection"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Destiny Dalseno (Walter and Eliza Hall Institute, Australia)
"Novel Fluorescent TNF Reporter Systems for Characterisation of TNF Expression"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Andrew Oberst (University of Washington, United States)
"It’s Not You, It’s Me: ZBP1 as a Driver of Autoinflammation"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Siddharth Balachandran (Fox Chase Cancer Center, United States)
"No Time to DAI: ZBP1-Triggered Cell Death in Influenza and Immunotherapy"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
General Discussion
7:55 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure