Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
New Roles for Bcl2 Proteins in Apoptosis and Homeostasis
Discussion Leaders: Sarah Garnish (The Walter and Eliza Hall Institute of Medical Research, Australia)
3:15 pm - 3:20 pm
Opening Remarks
3:20 pm - 3:35 pm
Kerstin Brinkmann (Walter and Eliza Hall Institue, Australia)
"Surprisingly, MCL-1 is not Essential for Embryonic and Haematopoietic Development but can be Replaced by Other Pro-Survival BCL-2 Family Members"
3:35 pm - 3:40 pm
Discussion
3:40 pm - 3:55 pm
Shuai Huang (The Walter & Eliza Hall Institute of Medical Research, Australia)
"Mitochondrial E3 Ubiquitin Ligase MARCHF5 Controls BAK Function Independently of BH3-Only Proteins"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Cell Death Programs Impact Inflammatory Responses
Discussion Leader: Isaac Babcock (University of Virginia, United States)
5:30 pm - 5:45 pm
Ivana Lessel (University Medical Center Hamburg-Eppendorf, Institute of Human Genetics, Germany)
"C-Terminal cFLIP Disruption in Humans Causes Intrauterine Multisystem Anomalies due to Aberrant Cell Death Response Switch"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Davia Blake (University of Pennsylvania, United States)
"Alternative Splicing of RNA within Apoptosis Genes Promote T cell Survival"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Maria Doglio (VIB-UGent, Belgium)
"Inflammasome Regulation of Auto-Inflammation Induced by Otulin Deficiency"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Eunjin Ju (Chungnam National University, South Korea)
"Necrosome-Mediated Control of Immune Response through NF-kB Activation"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Shannon Estadt (University of Michigan, United States)
"Interferon Alpha Promotes Ultraviolet Light-Mediated Keratinocyte Apoptosis in a Caspase-8 Dependent Manner"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Lydia Sibley (University of Virginia, United States)
"Function of Caspase 8 in Controlling Chronic Toxoplasma Gondii Infection"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Keynote Session: Mitochondrial Membrane Organization and Execution of Cell Death Programs
Discussion Leader: Kerstin Brinkmann (Walter and Eliza Hall Institue, Australia)
9:00 am - 9:15 am
Isaac Babcock (University of Virginia, United States)
"Myeloid Cell Expression of Caspase-1 is Necessary for Optimal Control of T. Gondii Infection in the Brain"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Dylan Neel (Harvard Medical School, United States)
"Gasdermin-E Mediates Mitochondrial Damage in Axons and Neuronal Cell Death"
9:35 am - 9:40 am
Discussion
9:40 am - 10:25 am
Ana Garcia-Saez (University of Cologne, Germany)
"Keynote: Mitochondrial Membrane Organization and Execution of Cell Death Programs"
10:25 am - 10:40 am
Discussion
10:40 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Panel Discussion
Discussion Leader: Georgia Atkin-Smith (WEHI, Australia)
1:30 pm - 2:30 pm
Panel Discussion
Key Components to Mentorship
Philipp Jost (Medical University of Graz, Austria)
Andrew Oberst (University of Washington, United States)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes