Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Cell Polarization Mechanisms |
| Discussion Leader: Ian Macara (Vanderbilt University Medical Center, USA) |
7:40 pm - 7:55 pm | Opening Remarks |
7:55 pm - 8:15 pm | Introduction by Discussion Leader |
8:15 pm - 9:00 pm | Daniel St. Johnston (University of Cambridge, United Kingdom) "Different Modes of Epithelial Polarity" |
9:00 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Polarity in Unicellular Organisms |
| Discussion Leader: Anne Spang (Biozentrum, University of Basel, Switzerland) |
9:00 am - 9:20 am | Introduction by Discussion Leader: Cell Polarity and Stress Response in S. cerevisiae |
9:20 am - 9:40 am | Daniel Lew (Duke University Medical Center, USA) "Mechanism of Gradient Sensing in Yeast via a Mobile Polarity Site" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Urs Jenal (Biozentrum, University of Basel, Switzerland) "Coordination of Caulobacter Cell Polarity and Cell Proliferation by a Small Signaling Molecule" |
10:10 am - 10:20 am | Discussion |
10:20 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Sophie Martin (University of Lausanne, Switzerland) "Focalization of Pheromone Signalling Promotes Cell Fusion in the Fission Yeast" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Paul Cullen (State University of New York at Buffalo, USA) "Spatial Landmarks Regulate a Cdc42-Dependent MAPK Pathway to Control Differentiation and the Response to Positional Compromise" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Daniel Dickinson (University of North Carolina at Chapel Hill, USA) "Unraveling PAR Protein Interactions with Single-Cell Biochemistry" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Akiko Satoh (Hiroshima University, Japan) "Mechanism of Domain Formation in Apical Membrane of Drosophila Photoreceptors" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Jody Rosenblatt (Huntsman Cancer Institute, University of Utah, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Polarity in Development: Stem Cells |
| Discussion Leader: Jeremy Nance (New York University School of Medicine, USA) |
7:30 pm - 7:50 pm | Introduction by Discussion Leader: Remodeling of C. elegans Primordial Germ Cells Through Polarized Pruning by the Soma |
7:50 pm - 8:10 pm | Elaine Fuchs (The Rockefeller University, USA) "Polarity and the Governance of Epithelial Stem Cells" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Ken Prehoda (University of Oregon, USA) "Insights into the Origin of Animal Cell Polarity
from the Resurrection of Ancient Proteins" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:00 pm | Ashley Rich (University of Chicago, USA) "Optogenetic Dissection of Drosophila Neuroblast Polarization" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:15 pm | Eurico Morais-de-Sa (Institute for Molecular and Cell Biology, Portugal) "Shaping Epithelial Apicobasal Polarity at Mitotic Exit" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Polarity in Development: Epithelia |
| Discussion Leader: Elizabeth Knust (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) |
9:00 am - 9:20 am | Introduction by Discussion Leader: The Crumbs Protein Complex - A Hub to Coordinate Adhesion, Polarity and Signaling |
9:20 am - 9:40 am | Barry Thompson (The Francis Crick Institute, United Kingdom) "Cdc42 Drives Positive Feedback by Activating Both aPKC and PAK Kinases at the Apical Domain of Epithelial Cells" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Bob Varelas (Boston University School of Medicine, USA) "Polarity Regulated
Hippo Pathway Signaling in the Airway Epithelium" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Fernando Martin-Belmonte (Spanish National Research Council (CSIC), Spain) "Wnt Signaling in Epithelial Morphogenesis and Patterning in Tubular Organs" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Michel Bagnat (Duke University, USA) "Apical Membrane Biogenesis in the Zebrafish Gut" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Bhuminder Singh (Vanderbilt University, USA) "Apical Mistrafficking of the EGF Receptor Ligand Epiregulin Disrupts Epithelial Polarity" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Senthil Muthuswamy (Harvard Medical School, USA) "The Role of Scribble in Mammary Gland Morphogenesis" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Epithelial Mechanobiology - Extrusion and Strain |
| Discussion Leader: Alpha Yap (The University of Queensland, Australia) |
7:30 pm - 7:50 pm | Introduction by Discussion Leader: Monitoring Junctional Tension for Local Tissue Surveillance |
7:50 pm - 8:10 pm | Jody Rosenblatt (Huntsman Cancer Institute, University of Utah, USA) "Hijacking Epithelial Cell Extrusion to Drive Tumor Formation and Invasion" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Ulrich Tepass (University of Toronto, Canada) "The Cell Biology of Neuroblast Ingression" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:00 pm | Adam Martin (Massachusetts Institute of Technology, USA) "Organizing the Contraction that Changes Tissue Shape" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:15 pm | Kathryn Worley (Rensselaer Polytechnic Institute, USA) "Chirally Biased Traction Forces Observed on Micropatterned Surfaces" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Polarity in Disease: Cancer |
| Discussion Leader: Luke McCaffrey (McGill University, Canada) |
9:00 am - 9:20 am | Introduction by Discussion Leader: Polarity and Epithelial Remodelling During Breast Cancer Progression |
9:20 am - 9:40 am | Andrea McClatchy (Harvard Medical School, USA) "Plasma Membrane Domain Organization in Morphogenesis and Tumorigenesis" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Andrew Ewald (Johns Hopkins University School of Medicine, USA) "Polarity Changes During Normal and Neoplastic Epithelial Morphogenesis" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Joseph Kissil (Scripps Research Institute, USA) "Merlin and Angiomotin - Coordinators of Signaling at Cell:Cell Junctions" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:30 am | Sandra Iden (University of Cologne, Germany) "Non-Cell Autonomous Suppression of Melanoma by the Epidermal Polarity Protein Par3 Through Control of Direct Keratinocyte-Melanocyte Interactions" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Danielle Park (Francis Crick Institute, United Kingdom) "Extracellular Matrix Anisotropy in Breast Cancer Invasion and Metastasis" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Aaron Mertz (Rockefeller University, USA) "How Is a Stratified Epithelium Built Mechanically In Vivo" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Teresa Zulueta-Coarasa (University of Toronto, Canada) "Dynamic Force Patterns Promote Collective Cell Migration" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Planar Polarity and Tissue Morphogenesis |
| Discussion Leader: Helen McNeill (Lunenfeld Tanenbaum Research Institute, Canada) |
7:30 pm - 7:50 pm | Introduction by Discussion Leader: Fat Cadherins and the Hippo Pathway in Tissue Organization |
7:50 pm - 8:10 pm | Danelle Devenport (Princeton University, USA) "Coordinating Planar Cell Polarity in an Expansive and Regenerative Tissue" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Sergei Sokol (Icahn School of Medicine at Mount Sinai, USA) "Interactions of Core PCP Proteins During Vertebrate Neural Tube Closure" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:00 pm | Kari Barlan (University of Chicago, USA) "Fat2 and Lar Define a Planar Signaling System Controlling Collective Cell Migration" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:15 pm | Masanori Nakayama (Max-Planck-Institute for Heart and Lung Research, Germany) "Asymmetric Distribution of the PAR-3/aPKC Complex in the Planar Axis Controls Vascular Inflammation" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Epithelial Polarity and Patterning |
| Discussion Leader: Terry Lechler (Duke University Medical Center, USA) |
9:00 am - 9:20 am | Introduction by Discussion Leader: Spindle Orientation in Epidermal Development and Disease |
9:20 am - 9:40 am | Jessica Feldman (Stanford University, USA) "Patterning the Microtubule Cytoskeleton During Cell Differentiation" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Katerina Ragkousi (Stowers Institute for Medical Research, USA) "Polarizing Nemotestella Embryonic Epithelia, One Cell Cycle at a Time" |
10:10 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Patrick Laprise (CHU de Québec-Université Laval, Canada) "Function and Regulation of the Protein Yurt Within the Polarity Network" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Andrew Gladden (University of Texas MD Anderson Cancer Center, USA) "Loss of Planar Polarization Disrupts Tension-Mediated Organization of the Primordial Epidermal Bulge Stem Cell Niche" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | David Sprinzak (Tel Aviv University, Israel) "A Synthetic Biology Approach for Studying Fat4-Dachsous1 Planar Cell Polarity Signaling" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Ceniz Zihni (University College London, United Kingdom) "An Evolutionarily Conserved Cdc42-Activated Morphogenetic Origin Controls Epithelial Polarity" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Polarity in Disease - PCD, Wound Healing, Immune Response |
| Discussion Leader: William Bement (University of Wisconsin-Madison, USA) |
7:30 pm - 7:50 pm | Introduction by Discussion Leader: Cellular Pattern Formation in Response to Plasma Membrane Damage |
7:50 pm - 8:15 pm | Paul Martin (University of Bristol, United Kingdom) "Live Imaging of Tissue Repair and Inflammation" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Jane Stinchcombe (University of Cambridge, United Kingdom) "The Leading Role of the Centrosome in Polarity of Immune Cells" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | General Discussion |
9:15 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |