Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Polarity: From Yeast to Vertebrates
Discussion Leader: Ulrich Tepass (University of Toronto, Canada)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:30 pm
Rong Li (Johns Hopkins University, USA)
"Actin-Based Forces in Asymmetric Meiotic Cell Division in Mouse Oocytes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Lilianna Solnica-Krezel (Washington University in St. Louis School of Medicine, USA)
"Dachsous Cadherin Regulates Early Cleavages and Polarized Cell Behaviors in Zebrafish Embryos by Promoting Microtubule Turnover"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Polarity and Embryos
Discussion Leader: Bob Goldstein (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 am
Introduction by Discussion Leader: Cell Polarization in the Early C. elegans Embryo
9:20 am - 9:40 am
Fumio Motegi (Temasek Lifesciences Laboratory, Singapore)
"Deconstruction and Reconstruction of C. elegans PAR Polarity"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Nathan Goehring (The Francis Crick Institute, United Kingdom)
"Regulation and Adaptation of PAR Network Dynamics During Development"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Nicolas Plachta (Institute of Molecular and Cell Biology, A*STAR, Singapore)
"Imaging How Cells Choose Their Fate, Shape and Position in the Early Mouse Embryo"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Kathryn Anderson (Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, USA)
"The Cellular Basis of the Mouse Gastrulation EMT"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Erik Griffin (Dartmouth College, USA)
"PLK-1 Kinase and PP1/SDS-22 Phosphatase Control Germ Plasm Segregation in the C. elegans Zygote"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Poster Previews
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polarity in Tissue Organization
Discussion Leader: Orion Weiner (UCSF School of Medicine, USA)
7:30 pm - 7:50 pm
Introduction by Discussion Leader: A Template for Actin Organization at the Leading Edge
7:50 pm - 8:10 pm
Francois Schweisguth (Institut Pasteur, France)
"Epithelial Morphogenesis and Patterning Dynamics"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Enrique Rodriguez-Boulan (Weill Cornell Medicine, USA)
"Single Cell RNAseq Analysis of Outer Retina and Choroid: Novel Insights on RPE Polarity, Retinal Signaling and Blinding Diseases"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Jeremy Nance (NYU School of Medicine, USA)
"Cell Polarization During C. elegans Organ Formation"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Polarity and Tissue Dynamics
Discussion Leader: Jennifer Zallen (Memorial Sloan Kettering Cancer Center, USA)
9:00 am - 9:20 am
Introduction by Discussion Leader: Signals, Forces and Cells: Decoding Tissue Morphogenesis
9:20 am - 9:40 am
Carl-Philipp Heisenberg (Institute of Science and Technology Austria, Austria)
"Ooplasmic Segregation in Zebrafish and Ascidians"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Yohanns Bellaiche (Institut Curie, France)
"Control of Epithelial Cell Division During Morphogenesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Hernan Lopez-Schier (Helmholtz Zentrum München, Germany)
"Planar Cell Inversions (PCI) Unveil a Novel Mode of Epithelial Planar Polarization"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Jennifer Mitchel (Harvard T.H. Chan School of Public Health, Harvard University, USA)
"Pseudostratified Epithelia Maintain Polarity During Collective Migration Through an Unjamming Transition"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Sergey Troyanovsky (Northwestern University, USA)
"LAP Proteins, Scribble, Erbin, and Lano Redundantly Regulate Epithelial Polarity and Apical Adhesion Complex"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polarity, Stem Cells and Cell Division
Discussion Leader: Benjamin (Buzz) Baum (University College London, United Kingdom)
7:30 pm - 7:50 pm
Introduction by Discussion Leader: Polarity at Cell Division
7:50 pm - 8:10 pm
Marcos Gonzalez-Gaitan (University of Geneva, Switzerland)
"Asymmetric Signaling Endosomes in Asymmetric Division"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Cecilia Moens (Fred Hutchinson Cancer Research Center, USA)
"Cell Polarity in the Vertebrate Nervous System: Neuron Migration and Axogenesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Yukiko Yamashita (University of Michigan, USA)
"Non-Random Sister Chromatid Segregation During Asymmetric Stem Cell Division in Drosophila "
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Polarity and Growth Regulation
Discussion Leader: Senthil Muthuswamy (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
9:00 am - 9:20 am
Introduction by Discussion Leader: Revealing the Jekyll and Hyde Behavior of Cell Polarity Proteins in Cancer
9:20 am - 9:40 am
David Bilder (University of California, Berkeley, USA)
"Tumors, TNF, and Low-Sugar JNK Food"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Tatsushi Igaki (Kyoto University, Japan)
"Tumor Suppression and Epithelial Maintenance by Polarity-Mediated Cell Competition"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Katja Röper (MRC Laboratory of Molecular Biology, United Kingdom)
"Radially-Polarised Cell Behaviours Drive Tube Budding from an Epithelium"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Alexandre Francou (Memorial Sloan Kettering Cancer Center, USA)
"Regulation and Quantitative Dynamic Analysis of EMT In Vivo "
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Sandra Iden (University of Cologne, Germany)
"Shared and Independent Functions of aPKC and Par3 in Skin Carcinogenesis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Andrew Tilston-Lunel (Boston University, USA)
"Loss of Epithelial Polarity Drives Pre-Malignant Airway Disease"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Poster Previews
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Polarity and Cancer
Discussion Leader: Richard Fehon (University of Chicago, USA)
7:30 pm - 7:50 pm
Introduction by Discussion Leader: Upstream Regulation of the Hippo Growth Control Pathway in Polarized Epithelia
7:50 pm - 8:10 pm
Ian Macara (Vanderbilt University Medical Center, USA)
"Dynamics of Polarized Vesicle Delivery to the Plasma Membrane"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Fanny Jaulin (Institut Gustave Roussy, France)
"Tumour Spheres with Inverted Polarity Are Malignant Cancer Intermediates Driving the Metastatic Dissemination of Hypermethylated Carcinomas"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Mirka Uhlirova (University of Cologne, Germany)
"The Role of Actin Crosslinkers in Controlling Tissue Growth and Tumorigenesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Miranda Hunter (University of Toronto, Canada)
"Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound Healing"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Paola Moreno-Roman (Stanford University, USA)
"Septate Junctions Coordinate Growth and Intercalation of Stem Cell Progeny During Epithelial Organ Turnover"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Polarity, Extrusion and Would Healing
Discussion Leader: Susan Parkhurst (Fred Hutchinson Cancer Research Center, USA)
9:00 am - 9:20 am
Introduction by Discussion Leader: Closing the Gap: Patterning Dynamics in Cell Wound Repair
9:20 am - 9:40 am
Yasuyuki Fujita (Hokkaido University, Japan)
"Calcium Wave Triggers Cell Extrusion"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Rodrigo Fernandez-Gonzalez (University of Toronto, Canada)
"Oxidative Stress Orchestrates Cell Polarity to Promote Rapid Embryonic Wound Repair"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Virgile Viasnoff (Mechanobiology Institute, National University of Singapore, Singapore)
"Single Cell Model for Hepatic Polarity"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
Javier Buceta (Lehigh University, USA)
"Scutoids, a Geometrical Solution to Three-Dimensional Packing of Curved Epithelia"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Frederick Campbell (Queen's University Belfast, United Kingdom)
"c-Src Regulation of Cortical Ezrin, Centrosome Dynamics and Mitotic Spindle Assembly"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Heike Folsch (Northwestern University, USA)
"AP-1B Facilitates Endocytosis in Lamellipodia"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Viola Lobert (Centre for Cancer Cell Reprogramming, University of Oslo, Norway)
"The Tumour Suppressor PHLPP2 Controls Spindle Orientation During Epithelial Morphogenesis"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polarity, Stem Cells and Regeneration
Discussion Leader: Carien Niessen (University of Cologne, Germany)
7:30 pm - 7:50 pm
Introduction by Discussion Leader: Cell and Tissue Polarization in Stratifying Epithelia
7:50 pm - 8:10 pm
Lucy O'Brien (Stanford University, USA)
"Collective Cell Dynamics of Epithelial Renewal and Remodeling"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Eduardo Moreno (Champalimaud Foundation, Portugal)
"Fitness Fingerprints of Human Cells"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Heidi Hehnly (SUNY Upstate Medical University, USA)
"Cytokinetic Bridge Triggers Lumen Formation In Vivo "
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Kiichiro Taniguchi (Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Japan)
"Polarity-Mediated Cell Competition Shapes Germ-Line Stem Cell Niche in Drosophila "
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure