Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Polarity Within and Across Cells
Discussion Leader: Yukiko Yamashita (Whitehead Institute/MIT/HHMI, United States)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Geraldine Seydoux (Johns Hopkins University School of Medicine, United States)
"Asymmetric Segregation of P granules in C. elegans Embryos"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Denise Montell (University of California, Santa Barbara, United States)
"Specialized Protrusions Coordinate Migratory Border Cell Cluster Cohesion via Scribble, Cdep, and Rac"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dynamics of Cell Polarization
Discussion Leader: Danelle Devenport (Princeton University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Daniel Lew (Duke University Medical Center, United States)
"Exploratory Polarization in Mating Yeast"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Paul Cullen (State University of New York at Buffalo, United States)
"Regulation of Cdc42 Protein Levels Impacts a Cell Differentiation Program in Yeast"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Jean-Léon Maître (Institut Curie, France)
"Mechanics of Blastocyst Morphogenesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
Nathan Goehring (The Francis Crick Institute, United Kingdom)
"A Common Origin for Positive Feedback and Plasma Membrane Specificity of the PAR Polarity Protein, PAR-2"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
Clemens Cabernard (University of Washington, United States)
"Cell and Mechanobiology of Asymmetric Stem Cell Divisions"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
Benjamin Lin (New York University School of Medicine, United States)
"Going With the Flow: Navigating Without Actin-based Protrusions in vivo "
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Dominique Bergmann (Stanford University, United States)
"Linking (and Unlinking) Cell Polarity and Cell Fate in Plant Epidermal Stem Cells"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Danelle Devenport (Princeton University, United States) and Ahna Skop (University of Wisconsin-Madison, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polarity Transitions During Development
Discussion Leader: Mike Boxem (Utrecht University, The Netherlands)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Ulrich Tepass (University of Toronto, Canada)
"Mitotic Polarity Oscillation in Epithelial Polarity and Tumor Progression"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Edwin Munro (University of Chicago, United States)
"How Oligomerization Shapes the Dynamics of Cell Polarization"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Sougata Roy (University of Maryland, United States)
"Lipid-modified FGF Directs its Polarized Cytoneme-mediated Signaling in the Drosophila Tracheoblast Niche"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Jessica Feldman (Stanford University, United States)
"Linking Cell and Tissue Polarity Information in the C. elegans Intestine"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Polarization and the Cytoskeleton
Discussion Leader: William Bement (University of Wisconsin-Madison, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Stephanie Gupton (University of North Carolina at Chapel Hill, United States)
"Coordinating Cytoskeletal and Plasma Membrane Remodeling During Neuronal Morphogenesis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Gunther Hollopeter (Cornell University, United States)
"The C. elegans ASPP Homolog APE-1 Is a Junctional Protein Phosphatase 1 Modulator"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Renata Basto (Institut Curie, France)
"Contributors of Mitotic Fidelity in the Mammalian Brain"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:00 am
Vincent Mirouse (CNRS, France)
"WAVE Regulatory Complex Facilitates Cell Intercalations Through the Generation of a Protrusive F-Actin Subpopulation at Tricellular Junctions"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
Gregg Gundersen (Columbia University Medical Center, United States)
"The Role of Nucleocytoskeleton Connections in Cell Polarity Generation and Maintenance"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
Suvrajit Saha (University of California, San Francisco, United States)
"Molecular Logic of mTORC2 Based Front-back Polarity Coordination in Moving Neutrophils"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Terry Lechler (Duke University, United States)
"Control of the Biogenesis of Endo-Lysosomal Systems in Professional Absorptive Cells"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polarity and Morphogenesis: Eggs and Embryos
Discussion Leader: Jessica Feldman (Stanford University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Yu-Chiun Wang (RIKEN Center for Biosystems Dynamics Research, Japan)
"A Push-pull System of Microtubule-spectrin Mechanics Controls Apical Cell Shape Homeostasis During Epithelial Folding"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Daniel Dickinson (University of Texas at Austin, United States)
"Exploding Worms: New Approaches to PAR Polarity in Early C. elegans Embryos"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Alexandre Francou (Memorial Sloan Kettering Cancer Center, United States)
"Quantitative Analysis of Apical Constriction During the Mouse Gastrulation EMT"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Sally Horne-Badovinac (University of Chicago, United States)
"Planar Polarization of Cell Protrusions for Rotational Epithelial Migration"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Polarity and Morphogenesis: Tissues and Organs
Discussion Leader: Sally Horne-Badovinac (University of Chicago, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Danelle Devenport (Princeton University, United States)
"Integrating Positional and Directional Cues During Collective Cell Migration"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Austin Baldwin (University of Texas at Austin, United States)
"Global Analysis of Cell Behavior and Protein Localization Dynamics Reveals Region-specific Functions for Shroom3 and N-cadherin During Neural Tube Closure"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Jeff Rasmussen (University of Washington, United States)
"Cellular Interactions Regulate Touch System Polarization During Zebrafish Organogenesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
Negar Balaghi (University of Toronto, Canada)
"Myosin Waves and a Mechanical Asymmetry Guide the Oscillatory Migration of Drosophila Cardiac Progenitors"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
Michel Bagnat (Duke University, United States)
"Developmental Regulation of Epithelial Polarization by pre-mRNA Splicing"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
Marissa Gredler (Sloan Kettering Institute, United States)
"Collective Radial Intercalation of the Mammalian Axial Mesoderm"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Shigeo Hayashi (RIKEN Center for Biosystems Dynamics Research, Japan, Japan)
"Nano-scale ECM Morphogenesis in Insect Exoskeletons"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Polarity Transitions During Disease
Discussion Leader: Terry Lechler (Duke University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
Ankita Jha (National Institutes of Health, United States)
"Front-rear Polarity Establishment During Bleb-based Cancer Cell Migration"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:10 pm
Erik Sahai (The Francis Crick Institute, United Kingdom)
"Mechanisms of Fibroblast Alignment and the Consequences of Defects"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Anne Classen (University of Freiburg, Germany)
"Affinity-Controlled Regulation of Aberrant Cell Elimination"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
General Discussion
9:00 pm - 9:20 pm
Sergei Sokol (Icahn School of Medicine at Mount Sinai , United States)
"Force Balance Controls Epithelial Cell Polarity and Behavior During Neural Tube Folding"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Asymmetric Division and Stem Cells
Discussion Leader: Dominique Bergmann (Stanford University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Xin Chen (HHMI, Johns Hopkins University, United States)
"Asymmetric Histone Inheritance in Cell Fate Determination"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Bryce LaFoya (University of Oregon, United States)
"An Actomyosin-polarized Membrane Reservoir Mediates the Unequal Divisions of Drosophila Neural Stem Cells"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Ahna Skop (University of Wisconsin-Madison, United States)
"The Midbody is a Novel, Translationally Competent, RNA-harboring Organelle Necessary for Intercellular Communication"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Mike Boxem (Utrecht University, The Netherlands)
"Functioning of Apical-basal Polarity Regulators in Postembryonic Development of C. elegans "
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
Jaclyn Fingerhut (Whitehead Institute, United States)
"mRNA Localization Mediates Maturation of Cytoplasmic Cilia in Drosophila Spermatogenesis"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
Julie Canman (Columbia University Irving Medical Center, United States)
"Cell Type-Specific Regulation of Cytokinesis"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Melissa McLellan (The Francis Crick Institute, United Kingdom)
"The Cell-specific Spindle Alignment in Epithelia by the N-terminal RASSF Proteins"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Homeostasis: Wound Healing and Extrusion
Discussion Leader: Yukiko Yamashita (Whitehead Institute/MIT/HHMI, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
William Bement (University of Wisconsin-Madison, United States)
"An Enzymatic Corral Establishes the Outer Boundary of a Rho Activity Wave"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Anthony Galenza (Stanford University School of Medicine, United States)
"Paac it Up: Basal Stem Cell Progeny Establish de novo Apical Polarity in a Protected Niche During Intestinal Epithelial Renewal"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Jane Stinchcombe (University of Cambridge, United Kingdom)
"Polarised Signaling in Killer T Cells"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Scott Williams (University of North Carolina at Chapel Hill, United States)
"AGS3 Inhibits LGN-driven Perpendicular Divisions During Epidermal Development"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure