Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Morphogenesis in Development
Discussion Leaders: Florent Peglion (The Francis Crick Institute, United Kingdom) and Sergio Simoes (University of Toronto, Canada)
3:45 pm - 4:20 pm
Carl-Philipp Heisenberg (Institute of Science and Technology Austria, Austria)
"Polarity and Morphogenesis in Development"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Mechanisms of Cell Polarization
This session will focus on the molecular details of polarity protein networks. Have new players or novel interactions between key components of these networks been found? Should we envisage any change in paradigms leading to revision of how polarity axis is established and maintained in different single cell models (from Dictyostelium directed migration to asymmetric partitioning of epithelial cell, neuroblast, oocytes or zygotes etc…)? Emphasis will be given to cue-reading and signal transduction strategies to polarize where and when it is required; but also to the elaboration of mathematical model integrating molecular details to reach systems-level scale, to identify the core features of polarity pattern formation.
Discussion Leaders: Rong Li (Johns Hopkins University, USA) and Nicolas Plachta (Institute of Molecular and Cell Biology, A*STAR, Singapore)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Melissa Pickett (Stanford University, USA)
"Establishment of Apical and Basolateral Polarity in the Embryonic Intestinal Epithelium"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Nikhil Mishra (Ludwig Maximilian University of Munich, Germany)
"Novel Role of the C. elegans Apoptotic Pathway in Asymmetric Cell Division"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Hien Bui (Institute of Biotechnology, University of Helsinki, Finland)
"Age-Selective Segregation of Peroxisomes During Stem Cell Division Is Mediated by the Mitotic Spindle"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Jyoti Misra (Waksman Institute of Microbiology, Rutgers University, USA)
"Interplay of Ubiquitination and Palmitoylation in Regulation of Fat-Hippo Signaling"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cell Polarity and Morphogenesis: How to Build a Polarized Tissue?
This session is dedicated to tissue polarity homeostasis. First we will focus on how animal or plant tissues acquire their “long-range” apico-basal and planar cell polarity. More specifically, the focus will be on how do groups of cells coordinate their internal polarized state to generate a more global, long-lasting axis of polarity (including polarized collective migration). Then we will ask how do tissues maintain their polarized state during wound healing, cell divisions, cell extrusions and cell movement (tissue polarity homeostasis)?
Discussion Leaders: Cecilia Moens (Fred Hutchinson Cancer Research Center, USA) and Carl-Philipp Heisenberg (Institute of Science and Technology Austria, Austria)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Miranda Hunter (University of Toronto, Canada)
"Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound Healing"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
Paola Moreno-Roman (Stanford University, USA)
"Septate Junctions Coordinate Growth and Intercalation of Stem Cell Progeny During Epithelial Organ Turnover"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Joseph Campanale (University of California, Santa Barbara, USA)
"The Basolateral Scribble Complex Promotes Cooperativity During Collective Migration"
10:20 am - 10:25 am
Discussion
10:25 am - 10:45 am
Sergio Simoes (University of Toronto, Canada)
"Drosophila Neuroblast Ingression: How Actomyosin and Apical Trafficking Drive an Epithelial to Mesenchymal Transition"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Cell Polarity and Diseases: Can Polarity Loss Cause Disease?
This session will conclude the seminar by looking at the impact of polarity alteration on disease progression. One key question to answer will be whether polarity loss can initiate tumour development. Numbers of studies have identified polarity genes as oncogenes or tumour suppressors in different animal models. But due to the impact of polarity genes loss on deeper epithelial organization, it has always been hard to acknowledge that it is the initial loss of polarity that drives tumour initiation. Whether polarity loss favours transformation is still largely unknown.
Discussion Leader: Tatsushi Igaki (Kyoto University, Japan)
1:30 pm - 1:40 pm
Introduction by Discussion Leader
1:40 pm - 2:00 pm
Martim Dias Gomes (Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Germany) and Soriba Letzian (Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Germany)
"Polarity Signaling Governs Epithelial Homeostasis by Coupling Cortical Contractility and Mitotic Fidelity"
2:00 pm - 2:05 pm
Discussion
2:05 pm - 2:25 pm
Zhang Peng (Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, China)
"Cdc42 Acts as a Tumor Suppressor in Liver by Regulating Hepatocyte Differentiation Through PAK1-YAP Axis"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
