| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Developing and Validating 3D Tissues for Predictive and Mechanistic Toxicology Studies |
| Discussion Leader: Jose Manautou (University of Connecticut, USA) |
| 3:45 pm - 3:50 pm | Opening Remarks |
| 3:50 pm - 4:05 pm | Lorin Jakubek (Sanofi, USA)
"Development of a 3D Rat Primary Hepatocyte Model for Predictive and Investigative Toxicology Screens" |
| 4:05 pm - 4:10 pm | Discussion |
| 4:10 pm - 4:25 pm | Marguerite Vantangoli (Brown University, USA)
"Quantification of Morphological and Molecular Changes Associated with Estrogenic Exposure in 3D MCF-7 Human Breast Microtissues" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Session: Organ-Chip and 3D Microtissue Models as the New Frontier in Toxicity Testing |
| Discussion Leaders: Ruth Roberts (Apconix, United Kingdom) and Alessandro Venosa (Rutgers University, USA) |
| 7:30 pm - 7:55 pm | John Wikswo (Vanderbilt University, USA)
"Application of Organ on a Chip Models to Toxicity Testing" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Sharon Presnell (Organovo, USA)
"3D Bioprinted Human Tissues as In Vitro
Models of the Tissue Response" |
| 8:25 pm - 8:30 pm | Discussion |
| Complex Tissue Models as a Means to Study Disease and the Chronic Injury Response |
| 8:30 pm - 8:45 pm | Pranita Kabadi (Brown University, USA)
"Visualization of 3-Dimensional Human Lung Microtissues for Assessment of Nanoparticle-Induced Toxicity" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Leah Norona (The Hamner-UNC Institute for Drug Safety Sciences, USA)
"Utility of exVive3DTM Human Liver Tissue for the Study of Chronic Liver Injury Leading to Fibrosis" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Peter Loskill (University of California, Berkeley, USA)
"Organs-on-a-Chip – Microphysiological Platforms as In Vitro Models of Cardiac and Adipose Tissue" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Mechanistic Insights to Liver Injury |
| Discussion Leader: Rhiannon Hardwick (Organovo, Inc, USA) |
| 9:00 am - 9:15 am | Dwayne Carter (The University of Texas Medical Branch, USA)
"Aryl Hydrocarbon Receptor Activation by Cinnabarinic Acid Is Required for Stanniocalcin-2 Mediated Protection Against Alcohol Induced Hepatic Injury" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Brandy Garzel (University of Maryland, Baltimore, USA)
"Mechanistic Insight into Metformin-Mediated Repression of the Bile Salt Export Pump (BSEP; ABCB11)" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Natalie Holman (University of North Carolina at Chapel Hill, USA)
"Alterations in the Content and Quantity of Exosomes Released by Primary Rat and Human Hepatocytes in Response to Toxicant Exposure: Evidence of a Role in Drug-Induced Liver Injury?" |
| 9:55 am - 10:00 am | Discussion |
| Mentorship Component: Career Development Panel |
| 10:00 am - 11:00 am | Panel Discussion |
| "Looking
Beyond Effective CV Construction: Are You Prepared for the Interview Process?" |
|
- Bethany Hannas (The Dow Chemical Company, USA)
- Jose Manautou (University of Connecticut, USA)
- Charlene McQueen (U.S. Environmental Protection Agency, USA)
- Ruth Roberts (Apconix, United Kingdom)
|
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Predicting the Toxicologic Response |
| Discussion Leader: Charlene McQueen (U.S. Environmental Protection Agency, USA) |
| 1:30 pm - 1:45 pm | Ezinne Okoro (Kumamoto University, Japan)
"Cytotoxic Effects of Neonicotinoids on Human Trophoblast Cells" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Phillip Wages (University of North Carolina at Chapel Hill, USA)
"The Role of Hydrogen Peroxide in the Oxidative Modification of Protein Targets in Human Bronchial Epithelial Cells Exposed to 1,2-Naphthoquinone" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Shaun McCullough (U.S. Environmental Protection Agency, USA)
"Transforming In Vitro Susceptibility Modeling at the Air-Liquid Interface: Integrating Cellular Signaling, Genetics, and Epigenetics" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
