Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Early Life Exposure and Disease
Discussion Leaders: Alessandro Venosa (University of Pennsylvania, USA) and Thomas Gonzalez (University of Michigan , USA)
3:45 pm - 3:50 pm
Opening Remarks
3:50 pm - 4:05 pm
Jorine Voss (University of Texas at Austin, USA)
"Exposure of Peripubertal Rats to Mono-(2-Ethylhexyl) Phthalate (MEHP) Leads to a Pro-Inflammatory Environment in the Testis with the Infiltration of Both Macrophages and Neutrophils"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Elizabeth Martin (University of North Carolina at Chapel Hill, USA)
"Sexual Epigenetic Dimorphism in the Human Placenta: Implications for Susceptibility to Stressors During the Prenatal Period"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microbiota and Development / Reproductive Toxicology
Discussion Leaders: Emma Bowers (Curriculum in Toxicology, University of North Carolina at Chapel Hill, USA) and Karilyn Sant (University of Massachusetts Amherst, USA)
7:30 pm - 7:55 pm
Stephanie Shore (Harvard T.H. Chan School of Public Health, USA)
"Obesity and Asthma: Microbiome-Metabolome Interactions"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Tamara Tal (U.S. Environmental Protection Agency, USA)
"Host-Associated Microbiota and Chemical Induced Developmental Toxicity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Dana Walsh (Mayo Clinic, USA)
"Metformin Protects Against Chemotherapy-Induced Loss of Gut Microbiota Diversity in Ovarian Cancer"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Alisa Suen (U.S. Environmental Protection Agency, USA)
"SIX1 Oncoprotein Is Necessary for Abnormal Uterine Basal Cell Development in Neonatally DES Exposed Mice"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Ludwik Gorczyca (Rutgers University, USA)
"Role for Efflux Drug Transporters in Placental Cell Syncytialization"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Uncovering Mechanisms Governing Tissue Metabolic Programming / Toxicogenomics / Immunotoxicology
Discussion Leaders: Rosa Chan (University of California, San Francisco, USA), Suzanne Martos (Johns Hopkins University, USA) and John Szilagyi (Rutgers University, USA)
9:00 am - 9:15 am
Katelyn Lavrich (University of North Carolina at Chapel Hill, USA)
"Air Pollutant 1,2-Naphthoquinone Inhibits Glycolysis Through Peroxide-Dependent Protein Inactivation in Human Bronchial Epithelial Cells"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Anna Pfalzer (Vanderbilt University, USA)
"Alterations in Arginine, Cholesterol and Energy Metabolism Are Rescued with Manganese Exposure in a Mouse Model of Huntington's Disease"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Kari Neier (University of Michigan School of Public Health, USA)
"Altered Early Life Pancreatic Redox Environment as a Potential Mechanism Linking Perinatal Phthalate Exposures with Altered Metabolic Profile in Adulthood"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Eva Vitucci (University of North Carolina at Chapel Hill, USA)
"A Cellular Game of Telephone: Trans-Tissue Reprogramming of Responses to Toxic Stimuli"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Christina Post (University of Rochester Medical Center, USA)
"AHR Activation During Development Skews Antiviral CD8+ T Cells Toward Senescence and Exhaustion"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Thomas Hammond (University of Basel, Switzerland)
"Do Acyl Glucuronide Metabolites of Carboxylic Acid Drugs Have a Potential to Elicit Idiosyncratic Hypersensitivity?"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Data Rigor and Reproducibility: Considerations for Statistical Analysis, Transparency, and Management
Discussion Leader: Emily Martell (University of Rhode Island, USA)
1:30 pm - 1:40 pm
Shaun McCullough (U.S. Environmental Protection Agency, USA)
"Increasing Reproducibility Through Quality Experimental Design and Methodology"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 2:05 pm
Glenn Begley (BioCurate Pty Ltd, Australia)
"The Current Problem with Rigor and Reproducibility"
2:05 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
Radhika Dhingra (U.S. Environmental Protection Agency, USA)
"Statistical Analysis 'Good Practices' to Improve Data Rigor"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes