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Cellular and Molecular Mechanisms of Toxicity (GRS)

Gordon Research Seminar

Mechanisms Governing Sexually Dimorphic Outcomes in Toxicology

August 10 - 11, 2019

Chairs Emma C. Bowers and Phillip A. Wages

Proctor Academy

204 Main Street

Andover, New Hampshire, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Cellular and Molecular Mechanisms of Toxicity is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

Selected presentations will feature the most novel approaches and exciting findings in cellular and molecular toxicology mechanisms. Drs. David Waxman (Boston University) and Patricia Silveyra (UNC-Chapel Hill) will deliver the keynote session focusing on the 2019 meeting theme, "Mechanisms Governing Sexually Dimorphic Outcomes in Toxicology". The meeting will also include a career development session centered on Science Outreach and Communication and will feature panelists from various scientific sectors.

Related Meeting

This GRS will be held in conjunction with the "Cellular and Molecular Mechanisms of Toxicity" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Target Organ Toxicity Discussion Leader: Enrique Fuentes-Mattei (University of Texas MD Anderson Cancer Center, USA)
3:45 pm - 4:00 pm	Steven Kunnen (Leiden University, The Netherlands) "Toxicogenomic-Based Gene Co-Expression Network Analysis for Quantitative Mode-of-Action Assessment of Chemical-Induced Organ Toxicity"
4:00 pm - 4:05 pm	Discussion
4:05 pm - 4:20 pm	Lauren Lewis (Texas A&M University, USA) "The Persistence of 1,3-Butadiene-Induced DNA Damage, Transcriptional Effects, and Chromatin State Alterations in C57BL6/J and CAST/EiJ Mice"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	In Vitro Toxicology Models and Inhalation Toxicology Discussion Leaders: Dusty Miller (Vanderbilt University, USA), Shaun McCullough (U.S. Environmental Protection Agency, USA) and Jessica Murray (University of Pennsylvania, USA)
7:30 pm - 7:45 pm	Madalena Cipriano (Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Germany) "Human Immunocompetent Choroid-on-a-Chip: A Key Tool for Studying Ocular Side Effects of Biological Drugs"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	Kyle Hawkins (Vanderbilt University, USA) "A Data-Driven Approach to Infer Transcriptomic State from Secretomic Measurements"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	Kimberly Rockley (ApconiX, United Kingdom) "In Vitro Evaluation of Anthracycline-Induced Cardiotoxicity and Mitigation by Perturbation of Angiotensin Signalling"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Samantha Faber (University of North Carolina at Chapel Hill, USA) "Beyond the Barrier: Trans-Epithelial Exposures Reveal Novel Roles for Oxidative Stress and Pro-Inflammation Within the Airway Microenvironment"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Alessandro Venosa (University of Pennsylvania, USA) "Lung Epithelial Cell Stress Driven by Surfactant Protein-C Mutation Predisposes to Enhanced Susceptibility to Inhaled Toxicant Exposure"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Cassandra Houser (University of Rochester Medical Center, USA) "Aryl Hydrocarbon Receptor Regulation of T Follicular Helper Cells"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Reproductive and Developmental Toxicology / Keynote Session: Mechanisms Governing Sexually Dimorphic Outcomes in Toxicology Discussion Leaders: Patrick Allard (University of California, Los Angeles, USA) and Archit Rastogi (University of Massachusetts Amherst, USA)
9:00 am - 9:15 am	Cassandra Meakin (University of North Carolina at Chapel Hill, USA) "Effects of Inorganic Arsenic (iAs) and Its Methylated Metabolites on Genomic and Epigenomic Signaling Within the Glucocorticoid Receptor (GR) Pathway in the Human Placenta"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	John Szilagyi (University of North Carolina at Chapel Hill, USA) "PFAS Alter Trophoblast Immune Signaling "
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	Christine Rygiel (University of Michigan, USA) "Perinatal Lead (Pb) Exposure's Trimester-Specific Effect on DNA Methylation in Umbilical Cord Blood"
9:55 am - 10:00 am	Discussion
10:00 am - 10:25 am	David Waxman (Boston University, USA) "Regulation of Liver Sex Differences: Epigenetics and Chromatin State"
10:25 am - 10:30 am	Discussion
10:30 am - 10:55 am	Patricia Silveyra (University of North Carolina at Chapel Hill, USA) "Sex Differences in the Lung Response to Environmental Agents"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Science Outreach and Communication Discussion Leaders: Katelyn Lavrich (National Toxicology Program Division, National Institute of Environmental Health Sciences, NIH, USA) and Joseph Laakso (Endocrine Society, USA)
1:30 pm - 1:45 pm	Jennifer Ufnar (Vanderbilt University, USA) "Outreach to K-12"
1:45 pm - 1:50 pm	Discussion
1:50 pm - 2:05 pm	Charlene McQueen (University of Arizona, USA) "How to Tailor Your Talk to the Appropriate Audience"
2:05 pm - 2:10 pm	Discussion
2:10 pm - 2:25 pm	Frederick Tyson (National Institute of Environmental Health Sciences, NIH, USA) "Outreach to At-Risk Populations"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Funding for this conference was made possible (in part) by 1 R13 ES 030569 - 01 from the National Institute of Environmental Health Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Cellular and Molecular Mechanisms of Toxicity

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