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Cellular and Molecular Mechanisms of Toxicity (GRS)

Gordon Research Seminar

Exploring Frontiers in Translational Toxicology: Linking Mechanistic Research to Real-World Applications

August 12 - 13, 2023
Chairs and
Proctor Academy
204 Main Street
Andover, New Hampshire, United States
 Venue and Travel Information

Conference Description

The Cellular and Molecular Mechanisms of Toxicity GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

Keynote speakers will discuss cutting-edge technologies that underpin predictive toxicology, which will fit with the theme for the 2023 GRS "Exploring Frontiers in Translational Toxicology.” At least five selected presentations will be chosen from submitted abstracts and will feature innovative and novel approaches in cellular and molecular toxicology mechanisms. The meeting will also include a career development session featuring mentors who will give diverse perspectives on building an online presence in the digital age.

Related Meeting

This GRS will be held in conjunction with the "Cellular and Molecular Mechanisms of Toxicity" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Exploring Frontiers in Translational Toxicology: Linking Mechanistic Research to Real-World Applications
Discussion Leaders: and
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:05 pm
"Advancing Brain Micro(patho)physilogical Systems Towards Understanding Gene Environmental Interactions in Autism"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
"Riding into the Frontier of Translational Toxicology on the AI bandwagon: Opportunities and Challenges"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Leveraging In Vivo, Ex Vivo, and Big Data to Explore Human-Relevant Mechanisms of Toxicity
Discussion Leaders: and
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"High-Speed Optical Mapping to Evaluate in vivo Heart and Brain Activities in Zebrafish Larvae Exposed to Pesticides"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"The role of Myeloid heme Oxygenase 1 in Ozone Induced Pulmonary Injury, Inflammation, and Antioxidant Responses"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Tissue-Resident Alveolar Macrophages Reduce Ozone-Induced Inflammation via MerTK Mediated Efferocytosis"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Unravelling Species Differences in Hepatic Stress Response Capacity to Inform the Selection of Animals for use in Preclinical Drug Safety Assessment"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"LRRC8 Modulates Excitation-Contraction Coupling in Human Airway Smooth Muscle Cells"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Linking In Vitro Models to Translational Adverse Outcomes
Discussion Leaders: and
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"Exposure to Perfluorooctanesulfonic Acid (PFOS) Increases the Formation of Proinsulin Disulfide-Linked Complexes in Pancreatic ßTC-6 Cells"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
"In Vitro High-Throughput Toxicological Assessment of E-Cigarette Flavors in Human Bronchial Epithelial Cells and the role of TRPA1 in Cinnamon Flavor-Induced Toxicity"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Toxicity of 2,2’,5,5’-Tetrachlorobiphenyl (PCB52) and its Human-Relevant Metabolites in Astrocytes"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Doxorubicin-Induced Cardiotoxicity: Exploring Cardiomyocyte Senescence and Associated Secreted Factors as Driving Mechanisms"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
"MEHP is Detrimental to Human Ovarian Follicles"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Building an Effective Digital Presence
Discussion Leaders: and
1:30 pm - 1:40 pm
"Building Your Brand through LinkedIn and Networking"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
"Leveraging Your Network to Land a Job in the Pharmaceutical Industry"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
"Communicating Toxicology Online"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes

Contributors

Research reported in this publication was supported by the National Institute Of Environmental Health Sciences of the National Institutes of Health under Award Number R13ES035246-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Cellular and Molecular Mechanisms of Toxicity
Additional Fee Info

Cellular and Molecular Mechanisms of Toxicity
August 10 - 15, 2025


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