Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Exploring Frontiers in Translational Toxicology: Linking Mechanistic Research to Real-World Applications
Discussion Leaders: Samantha Korver (University of Liverpool, United Kingdom) and Archit Rastogi (Ionis Pharmaceuticals, United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:05 pm
Lena Smirnova (Johns Hopkins University, United States)
"Advancing Brain Micro(patho)physilogical Systems Towards Understanding Gene Environmental Interactions in Autism"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Matthew Martin (Pfizer Inc., United States)
"Riding into the Frontier of Translational Toxicology on the AI bandwagon: Opportunities and Challenges"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Leveraging In Vivo , Ex Vivo , and Big Data to Explore Human-Relevant Mechanisms of Toxicity
Discussion Leaders: Lauren Aleksunes (Rutgers University, United States) and Yizhou Yu (University of Cambridge, United Kingdom)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
Isabel Forner-Piquer (Brunel University London, United Kingdom)
"High-Speed Optical Mapping to Evaluate in vivo Heart and Brain Activities in Zebrafish Larvae Exposed to Pesticides"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Samuel Cochran (Ohio State University, United States)
"The role of Myeloid heme Oxygenase 1 in Ozone Induced Pulmonary Injury, Inflammation, and Antioxidant Responses"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Marissa Guttenberg (Duke University, United States)
"Tissue-Resident Alveolar Macrophages Reduce Ozone-Induced Inflammation via MerTK Mediated Efferocytosis"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Hannah Coghlan (University of Liverpool, United Kingdom)
"Unravelling Species Differences in Hepatic Stress Response Capacity to Inform the Selection of Animals for use in Preclinical Drug Safety Assessment"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Joanna Woo (Rutgers University, United States)
"LRRC8 Modulates Excitation-Contraction Coupling in Human Airway Smooth Muscle Cells"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Linking In Vitro Models to Translational Adverse Outcomes
Discussion Leaders: Heather Wallace (University of Aberdeen, United Kingdom) and Tarek Mamdouh Abdelghany (The University of Aberdeen, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
Marjorie Marin (University of Massachusetts Amherst, United States)
"Exposure to Perfluorooctanesulfonic Acid (PFOS) Increases the Formation of Proinsulin Disulfide-Linked Complexes in Pancreatic ßTC-6 Cells"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
Felix Effah (UK Health Security Agency, United Kingdom)
"In Vitro High-Throughput Toxicological Assessment of E-Cigarette Flavors in Human Bronchial Epithelial Cells and the role of TRPA1 in Cinnamon Flavor-Induced Toxicity"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Neha Paranjape (University of Iowa, United States)
"Toxicity of 2,2’,5,5’-Tetrachlorobiphenyl (PCB52) and its Human-Relevant Metabolites in Astrocytes"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
Laura Booth (Newcastle University, United Kingdom)
"Doxorubicin-Induced Cardiotoxicity: Exploring Cardiomyocyte Senescence and Associated Secreted Factors as Driving Mechanisms"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
Eleftheria Panagiotou (Karolinska Institutet, Sweden)
"MEHP is Detrimental to Human Ovarian Follicles"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Building an Effective Digital Presence
Discussion Leaders: Rhiannon Hardwick (Bristol Myers Squibb, United States) and Aiman Abzhanova (UNC Chapel Hill, United States)
1:30 pm - 1:40 pm
Lauren Aleksunes (Rutgers University, United States)
"Building Your Brand through LinkedIn and Networking"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Archit Rastogi (Ionis Pharmaceuticals, United States)
"Leveraging Your Network to Land a Job in the Pharmaceutical Industry"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Anne Chappelle (SafeBridge Regulatory & Life Sciences Group, United States)
"Communicating Toxicology Online"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
