Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: CAZymes: From Industry to Fundamentals
Discussion Leader: Katja Johansen (University of Copenhagen, Denmark)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:30 pm
Per Falholt (Per Falholt Global R&D Advisory Services A/S, Denmark)
"Developing Carbohydrases for Industrial Applications"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Kiyohiko Igarashi (University of Tokyo, Japan / VTT Technical Research Centre of Finland, Finland)
"Advanced Research in Cellulase Science: Neutron Crystallography and Traffic Simulator"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellulases
and the Deconstruction of Plant Cell Walls for Biofuels and Biorefinery
Discussion Leader: Mike Himmel (National Renewable Energy Laboratory, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Seema Singh (Sandia National Laboratories, USA)
"Development of Synbio Chassis and Tools for Lignin Valorization"
9:35 am - 9:45 am
Discussion
9:45 am - 10:00 am
Selected from Poster Abstracts: Tina Jeoh (University of California, Davis, USA)
"Defining the Productive Enzyme Binding Capacity of Cellulosic Substrates"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Selected from Poster Abstracts: Heather Mayes (University of Michigan, USA)
"The Advantages of a Distant Cellulase Catalytic Base"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Yannick Bomble (National Renewable Energy Laboratory, USA)
"Biomass Degradation by Thermophiles: What Have We Learned and Can We Improve Their Cellulolytic Activity?"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Roman Brunecky (National Renewable Energy Laboratory, USA)
"Production and Evaluation of Synthetic Multifunctional Cellulases in Fungal Systems"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Selected from Poster Abstracts: Johan Larsbrink (Chalmers University of Technology, Sweden)
"Biochemical and Structural Diversity in Carbohydrate Esterase Family 15"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellulosomes
Discussion Leader: Edward Bayer (Weizmann Institute of Science, Israel)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Lior Artzi (Weizmann Institute of Science, Israel)
"To Be or Not To Be – Attached: The Cellulosome Story"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Carlos Fontes (University of Lisbon, Portugal)
"Dynamic Versus Static Models of Cohesin-Dockerin Interaction"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Selected from Poster Abstracts: Rafael Bernardi (University of Illinois at Urbana-Champaign, USA)
"Unraveling the Molecular Mechanisms Guiding the Extraordinary Mechanical Stability of Cellulosomal Complexes"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Gut Microbiota and Complex Carbohydrates
Discussion Leader: Harry Gilbert (University of Newcastle, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Justin Sonnenburg (Stanford University School of Medicine, USA) and Erica Sonnenburg (Stanford University School of Medicine, USA)
"Complex Carbohydrates and Extinctions of Gut Microbes"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Michael Patnode (Washington University in St. Louis, USA)
"Identifying Human Gut Microbiota-Targeted Food Ingredients and Their Mechanisms of Action"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Nicole Koropatkin (University of Michigan Medical School, USA)
"Molecular Details of Glycan Scavenging at the Cell Surface"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Harry Flint (University of Aberdeen, United Kingdom)
"The Role of Firmicutes Bacteria in Plant Polysaccharide Utilization in the Gut"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Carbohydrate-Active Enzymes of the Microbiota
Discussion Leader: Harry Brumer (University of British Columbia, Canada)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Gabrielle Veronese (Institut National des Sciences Appliquees, France)
"Carbohydrate Foraging by Gut Bacteria: Inputs from Functional Metagenomics"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Nathalie Juge (Institute of Food Research, United Kingdom)
"Mechanistic Insights into the Mucin-Degrading Strategy of the Gut Symbiont Ruminococcus gnavus "
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Selected from Poster Abstracts: Wade Abbott (Agriculture and Agri-Food Canada, Canada)
"Learning from Nature: Harnessing Rare Enzyme Activities from an Intestinal Bacterium to Engineer an Artificial Metabolic Pathway"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
LPMOs
and Redox Enzymes
Discussion Leader: Paul Walton (University of York, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Leila Lo Leggio (University of Copenhagen, Denmark)
"Recent Progress in the Structural Characterization of LPMOs"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Makoto Yoshida (Tokyo University of Agriculture and Technology, Japan)
"Auxiliary Activity Family 12: Unique PQQ-Dependent Redox Enzymes"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Jean-Guy Berrin (INRA, France)
"Recent
Insights into Fungal Lytic Polysaccharide Monooxygenases"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Katja Johansen (University of Copenhagen, Denmark)
"The Biological Role of LPMOs"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structural
and Mechanistic Characterization of CAZymes
Discussion Leader: Mark Morrison (Diamantina Institute, University of Queensland, Australia)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Selected from Poster Abstracts: Bastien Bissaro (Norwegian University of Life Sciences, Norway)
"Are LPMOs Monooxygenases?"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:25 pm
Lynne Howell (The Hosptal for Sick Children, Canada)
"Exploiting Hydrolases for Biofilm Prevention and Disruption"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
Gideon Davies (University of York, United Kingdom)
"Enzymes, Itineraries and Destinations"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Substrates and Assays for Discovery and Applications
Discussion Leader: Gabrielle Veronese (Institut National des Sciences Appliquees, France)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
William Willats (Newcastle University, United Kingdom)
"New Tools for Closing the Gap Between CAZyme Discovery and Characterization"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Marie-Christine Ralet (INRA, France)
"Soleil Synchrotron Facilities to Enable a Better Understanding of Enzyme Diffusion in Complex Substrates"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Selected from Poster Abstracts: John Evans (AB Biotek, USA)
"Secretion of GH15 Glucoamylases by Saccharomyces in Fuel Ethanol Production"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Selected from Poster Abstracts: Andrew Hettle (University of Victoria, Canada)
"A Molecular View of Carbohydrate-Specific Sulfatases that Participate in Polysaccharide Depolymerization"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts: Akihiko Nakamura (Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Japan)
"Direct Observation of 1 nm Steps of Chitinase A Molecules with Gold Nano Probes"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Selected from Poster Abstracts: Jan-Hendrik Hehemann (MARUM - Center for Marine Environmental Sciences, University of Bremen, Germany)
"Enzymatic Degradation of Methyl-Protected Sugars by Marine Microbes"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: CAZymes: More Genes, Enzymes and Activities
Discussion Leader: Gideon Davies (University of York, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:10 pm
Sean Gilmore (University of California, Santa Barbara, USA)
"A Parts List for Fungal Cellulosomes by Comparative Genomics"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:55 pm
Harry Gilbert (University of Newcastle, United Kingdom)
"The Human Gut Microbiota: A Treasure Trove of Novel CAZymes"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
General Discussion
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure