Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Axonal Injury Response: Preparation for Regeneration
Discussion Leader: Michael Beattie (University of California, San Francisco, USA)
7:40 pm - 8:05 pm
Marco Terenzio (Weizmann Institute of Science, Israel)
"Retrograde Injury Response and Mechanism in Axons"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Jeffery Twiss (University of South Carolina, USA)
"Local Axonal Translation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Yishi Jin (University of California, San Diego, USA)
"DLK in Regeneration"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic/Epigenetic Preparation for Regeneration
Discussion Leader: Edmund Hollis (Burke Neurological Institute, Weill Cornell Medicine, USA)
9:00 am - 9:30 am
Ilaria Palmisano (Imperial College London, United Kingdom)
"Epigenetic Signatures Discriminate Between Regenerative Failure and Growth"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
William Cafferty (Yale University, USA)
"The Corticospinal Regeneration Transcriptome"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:30 am
Vance Lemmon (Miami Project to Cure Paralysis, USA)
"Epigenetics and Bioinformatics"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
Beth Harvey (University of Pennsylvania, USA)
"Optic Nerve Regeneration in the Larval Zebrafish Reveals Mechanisms Promoting Spontaneous CNS Regeneration"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ariel Levine (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Single Cell Profiling of the Mouse Spinal Cord"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Erna van Niekerk (University of California, San Diego, USA)
"Enhancing Corticospinal Regeneration After SCI"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Jacqueline Bresnahan (University of California, San Francisco, USA) and Yishi Jin (University of California, San Diego, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transcriptional and Intrinsic Control of Regeneration
Discussion Leader: Armin Blesch (Indiana University School of Medicine, USA)
7:30 pm - 7:55 pm
Zhigang He (Harvard Medical School, USA)
"Intrinsic Growth Programs"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Binhai Zheng (University of California, San Diego, USA)
"DLK in Spinal Cord Regeneration"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Lukas Neukomm (University of Lausanne, Switzerland)
"Degeneration of a Drosophila Axon"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Michael Kong (Old Dominion University, USA)
"Promoting Axonal Regrowth After Acute Spinal Cord Injury by Synergizing Redox Signaling and Electrical Stimulation with Gas Plasma"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Mediators of Axonal Growth
Discussion Leader: Simone Di Giovanni (Imperial College London, United Kingdom)
9:00 am - 9:30 am
Runyi Tian (University of California, San Diego, USA)
"Wnt Signaling in Axon Guidance and Spinal Cord Injury"
9:30 am - 9:40 am
Discussion
9:40 am - 10:15 am
James Fawcett (University of Cambridge, United Kingdom)
"Integrins"
10:15 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:30 am
Frank Bradke (German Center for Neurodegenerative Diseases, Germany)
"Tubulins in Regeneration"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ona Bloom (The Feinstein Institute, Northwell Health / Zucker School of Medicine at Hofstra/Northwell, USA)
"Biomarkers of Spontaneous Recovery from Traumatic SCI"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Dylan McCreedy (Texas A&M University, USA)
"Spleen Tyrosine Kinase Augments Acute Neutrophil Activation and Worsens Long-Term Functional Recovery Following Spinal Cord Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Britta Eickholt (Institute of Biochemistry, Charite - Universitätsmedizin Berlin, Germany)
"Injury Induced Drebrin Controls Astrogliosis and Scar Formation by Controlling Tubular Endosomes and Adhesion Responses"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuroinflammation and Systemic Mechanisms
Discussion Leader: Jacqueline Bresnahan (University of California, San Francisco, USA)
7:30 pm - 7:55 pm
Jan Schwab (The Ohio State University College of Medicine, USA)
"Systemic Inflammatory Processes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Roman Giger (University of Michigan Medical School, USA)
"Immune Mechanisms in Neural Repair"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Wolfram Tetzlaff (International Collaboration on Repair Discoveries (ICORD) / University of British Columbia, Canada)
"Ketogenic Diet"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Lyandysha Zholudeva (Drexel University College of Medicine, USA)
"Intermittent Hypoxia Enhances Connectivity of Transplanted Neural Cells with the Injured Cervical Spinal Cord"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neuro-Glial Interactions and Extracellular Matrix
Discussion Leader: James Fawcett (University of Cambridge, United Kingdom)
9:00 am - 9:25 am
Michael Sofroniew (University of California, Los Angeles, USA)
"Astrocytes and Growth Factors to Bridge Spinal Cord Lesions"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Jerry Silver (Case Western Reserve University School of Medicine, USA)
"Role of Glia in the Formation of Functional Bridges Across Large Spinal Cord Lesions"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Elizabeth Bradbury (King's College London, United Kingdom)
"Chondroitinase in Spinal Cord Injury"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Ephron Rosenzweig (Center for Neural Repair, University of California, San Diego, USA)
"Chondroitinase in Primate Spinal Cord Injury"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
James Guest (University of Miami, USA)
"Longitudinal Neurophysiological Observations After Autologous Schwann Cell Transplantation in Sub-Acute Complete Thoracic Spinal Cord Injury"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Isobel Scarisbrick (Mayo Clinic, USA)
"How Thrombin Limits the Capacity for Neural Repair After SCI"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Yuanquan Song (The Children's Hospital of Philadelphia / University of Pennsylvania, USA)
"The Atr-Chek1 Pathway Inhibits Axon Regeneration Independent of DNA Damage"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Experience-Dependent Plasticity
Discussion Leader: Ariel Levine (National Institute of Neurological Disorders and Stroke, NIH, USA)
7:30 pm - 7:55 pm
Anne Engmann (Harvard University, USA)
"Reticulospinal Plasticity After Incomplete SCI"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
John Martin (CUNY School of Medicine, USA)
"Cortical Stimulation"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Gregoire Courtine (Swiss Federal Institute of Technology (EPFL), Switzerland)
"Patterned Epidural Stimulation After SCI"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Radhika Puttagunta (University Hospital Heidelberg, Germany)
"Exercise-Reversible Nociceptive Plasticity and Peripheral Alterations in Relation to Spinal Cord Injury-Induced Neuropathic Pain"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells: Endogenous and Transplanted
Discussion Leader: Jerry Silver (Case Western Reserve University School of Medicine, USA)
9:00 am - 9:30 am
Murray Blackmore (College of Health Sciences, Marquette University, USA)
"KLF7 and Neural Stem Cells in Regeneration"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Michael Lane (Drexel University, USA)
"Spinal Interneurons, Plasticity and Repair After Cervical Spinal Cord Injury"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:15 am
Paul (Pengzhe) Lu (University of California, San Diego, USA)
"Neural Stem Cells"
11:15 am - 11:30 am
Discussion
11:30 am - 11:40 am
Jacob Koffler (University of California, San Diego, USA)
"Bioengineered Scaffold Containing Neural Stem Cell in SCI"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Juan Larrain (Pontificia Universidad Católica de Chile, Chile)
"Role of Sox2+ Cells in Spinal Cord Regeneration in the Frog Xenopus laevis "
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Eleni Sinopoulou (University of California, San Diego, USA)
"The Primate Corticospinal Projectome"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Philippa Warren (King's College London, United Kingdom)
"Oxygen Transport Mediates Rapid Recovery of Diaphragm Function Following Chronic Spinal Injury"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Translational Neuroscience
Discussion Leader: Jan Schwab (The Ohio State University College of Medicine, USA)
5:30 pm - 5:55 pm
Brian Kwon (ICORD, University of British Columbia , Canada)
"Surrogate Markers in SCI Clinical Trials"
5:55 pm - 6:05 pm
Discussion
6:05 pm - 6:30 pm
Bjorn Zorner (Spinal Cord Injury Centre, Balgrist University Hospital, Switzerland)
"Anti-Nogo-A Antibody Clinical Trials"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
John Steeves (University of British Columbia, Canada)
"The Way Forward in SCI Clinical Trials"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure