Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Non-Mammalian Animal Models of Axonal Injury
Discussion Leader: Yishi Jin (University of California San Diego, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Melissa Rolls (Pennsylvania State University, United States)
"Studying the Cell Biology of Axon and Dendrite Regeneration in Drosophila"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Marc Hammarlund (Yale University, United States)
"Molecular Reconstruction of Axons and Synapses During Regeneration"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Mayssa Mokalled (Washington University School of Medicine, United States)
"Comparative Approaches Reveal Regenerative Mechanisms in the Spinal Cord"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Axon Growth and Guidance in Development and Injury
Discussion Leader: Michael Sofroniew (University of California, Los Angeles, United States)
9:00 am - 9:50 am
Jeffrey Macklis (Harvard University, United States)
"Subcellular Molecular Machinery for Circuit-Specific Development, Function, and (potentially) Regeneration: Distinct and Dynamic Growth Cone vs. Soma Transcriptomes, Proteomes, and Local Translational Regulation in Cerebral Cortex Projection Neurons"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
Coffee Break
10:25 am - 10:50 am
Jeffery Twiss (University of South Carolina, United States)
"Local RNA Destabilization Hinders Axon Regeneration"
10:50 am - 11:00 am
Discussion
11:00 am - 11:25 am
Kevin (Kyung) Park (University of Miami, United States)
"Mechanisms Underlying Neuron Subtype Specific Regeneration and Target Innervation"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Mike Fainzilber (Weizmann Institute of Science, Israel)
"SINEs of Injury"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Julia Kaiser (Burke Neurological Institute, United States)
"Development of Cortical Projections to the Brainstem vs. Cervical Spinal Cord"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Elizabeth Bradbury (King's College London, United Kingdom), Victoria Abraira (Rutgers University, United States) and Jaclyn Eisdorfer (Rutgers University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Cell Communication: Local Inflammatory and Non-Inflammatory Post-Injury Responses
Discussion Leader: Binhai Zheng (University of California, San Diego, United States)
7:30 pm - 7:55 pm
Michael Sofroniew (University of California, Los Angeles, United States)
"Time Course, Regulation and Functions of Astrocyte Border Formation After SCI"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Andrea Tedeschi (The Ohio State University, United States)
"Overcoming Pericyte-Mediated Entrapment Aids Axon Regeneration by Providing Vasculature Bridges for SCI Repair"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Hongyan Zou (Icahn School of Medicine at Mount Sinai, United States)
"Microglia/Macrophages Orchestrate Regenerative Track and Glial Organization after Axonal Injury"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Zhe Shen (Devision of Biological Science, UCSD, United States)
"Accelerating Glial Scar Formation by Promoting Astrocyte Polarization and Differentiation"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanisms of Injury-Dependent Pain and Nociception
Discussion Leader: Armin Blesch (University of California, San Diego, United States)
9:00 am - 9:25 am
Victoria Abraira (Rutgers University, United States)
"A Machine-Vision Approach for Automated Locomotor Recovery Analysis at Millisecond Timescales"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Matthew Dalva (Thomas Jefferson University, United States)
"Attenuation of Neuropathic Pain Following Cervical Spinal Cord Injury by Modulating the EphB-NMDAR Interaction in Rodents."
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Rebecca Seal (University of Pittsburgh, United States)
"Dorsal Horn Circuits as Therapeutic Targets for Persistent Pain"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Andrew Tan (Yale University, United States)
"Dendritic Spine Dynamics after Injury: An Intravital Structural Study of Pain"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Franziska Mueller (Imperial College London, United Kingdom)
"Cited2-Dependent Reversal of Neuronal Polarisation Promotes Axonal Regeneration After Spinal Cord Injury"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Ana Vivinetto (Burke Neurological Institute, United States)
"Targeting Epithelial-to-mesenchymal Transition-like Signaling in Astrocytes to Improve Outcomes Following SCI"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolism-Dependent Mechanisms and Modifications in the Context of Nervous System Injury
Discussion Leader: Alyson Fournier (McGill University, Canada)
7:30 pm - 7:55 pm
Zu-Hang Sheng (National Institute of Neurological Disorders and Stroke, NIH, United States)
"Reprogramming Mitochondrial Transport and Energy Metabolism in CNS Regeneration"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Yuanquan Song (The Children's Hospital of Philadelphia / University of Pennsylvania, United States)
"Promoting Regeneration With Glial Metabolic Reprogramming"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Jessica Chadwick (Imperial College London, United Kingdom)
"A Role of a Gut Microbiome Metabolite in Axonal Regeneration After Injury"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Dalia Halawani (Mount Sinai School of Medicine, United States)
"A Circadian-Gated Neuroepigenetic Program that Mediates Intrinsic and Neuroimmune Regenerative Responses in Dorsal Root Ganglia"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neurotechnologies and Novel Approaches
Discussion Leader: Hongyan Zou (Icahn School of Medicine at Mount Sinai, United States)
9:00 am - 9:50 am
Ole Kiehn (University of Copenhagen, Denmark)
"Brainstem and Spinal Circuits For Locomotion In Health and Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
Andras Lakatos (University of Cambridge, United Kingdom)
"Human Corticospinal Axon Repair and Degeneration in Organoid Models"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Chun-Li Zhang (UT Southwestern Medical Center, United States)
"Reprogramming The Resident Glia For Regeneration"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Binhai Zheng (University of California, San Diego, United States)
"Multicellular Role of DLK and LZK in Spinal Cord Injury"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Xiaofei Guan (Weill Cornell Medicine, United States)
"Multi-photon Imaging of Corticospinal Tract Target Interneurons"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Neurocircuitry and Neurostimulation After Spinal Injury
Discussion Leader: Jack Martin (City University of New York School of Medicine, United States)
7:30 pm - 8:00 pm
Polina Anikeeva (Massachusetts Institute of Technology, United States)
"Manipulation of Neural Circuits with Fiber-Based Tools and Nanomagnetic Approaches"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Gregoire Courtine (Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland)
"Spinal Cord Gateways to Restore Neurological Functions"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Jack Martin (City University of New York School of Medicine, United States)
"Corticospinal System Neuromodulation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regenerative Approaches Following Spinal Cord Injury
Discussion Leader: James Guest (University of Miami, United States)
9:00 am - 9:25 am
Mark Tuszynski (University of California, San Diego, United States)
"Reversion of Adult Neurons to an Embryonic Transcriptional State Following SCI"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Samuel Stupp (Northwestern University, United States)
"Bioactive Nanostructures With Enhanced Supramolecular Motion Promote Recovery From Spinal Cord Injury"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Jae Lee (University of Miami, United States)
"Single Cell Analysis of Spinal Cord Injury Pathology"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Roman Giger (University of Michigan Medical School, United States)
"Single Cell Transcriptomics Approach for Axon Regeneration"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Claudia Kathe (Swiss Federal Institute of Technology, Lausanne (EPFL), Switzerland)
"Molecular Cartography Identifies the Neurons that Restore Walking after Paralysis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Faith Brennan (The Ohio State University, United States)
"Microglia Coordinate Cellular Interactions During Spinal Cord Repair"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical Translation in Spinal Cord Injury
Discussion Leaders: Jan Schwab (The Ohio State University College of Medicine, United States)
7:30 pm - 8:00 pm
James Guest (University of Miami, United States)
"Emerging Trends and Innovations in SCI Clinical Trials"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Michael Fehlings (University of Toronto, Canada)
"Tackling the Challenge of Chronic Cervical Spinal Cord Injury with Engineered Neural Stem Cells and Targeted Rehabilitation Strategies"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure