Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Centromere Basics: Composition and Function |
| Discussion Leader: Rachel O'Neill (University of Connecticut, USA) |
7:40 pm - 7:45 pm | Introduction by Discussion Leader |
7:45 pm - 8:20 pm | Sue Biggins (Fred Hutchinson Cancer Research Center / Howard Hughes Medical Institute, USA) "Reconstituting Kinetochore Functions In Vitro" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:05 pm | Gary Karpen (Lawrence Berkeley National Laboratory, USA) "Close Encounters with the Dark Side: Centromeres and Cancer" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biophysical and Structural Properties of Centromeres |
| Discussion Leader: Daniel Foltz (Northwestern University, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Kerry Bloom (University of North Carolina at Chapel Hill, USA) "Biophysical Basis of
Centromere Function" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Yamini Dalal (National Cancer Institute, NIH, USA) "Dyad-Proximal Modifications in the CENP-A Nucleosome Influence Centromere Dynamics In Vivo" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:40 am | Selected from Poster Abstracts: Cara Vaughan (Institute of Structural and Molecular Biology, United Kingdom) "Crystal Structure of the Sgt1-Skp1 Complex: Recruiting Hsp90 to CBF3 of the Yeast Kinetochore" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Don Cleveland (Ludwig Institute for Cancer Research, USA) "Centromere Maintenance Through DNA
Replication-Dependent Error Correction of CENP-A Deposition" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Selected from Poster Abstracts: Konstanty Cieslinski (European Molecular Biology Laboratory, Germany) "Structural Studies of the Budding Yeast Kinetochore Using Dual-Color Super-Resolution Microscopy" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Charles Asbury (University of Washington, USA) "Using Single Molecule Biophysics to Uncover How
Chromosomes Are Segregated" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Rachel O'Neill (University of Connecticut, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Meiotic Specialization of Centromeres |
| Discussion Leader: Michael Lampson (University of Pennsylvania, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Scott Hawley (Stowers Institute for Medical Research, USA) "The Structure of the Pericentromeric
Synaptonemal Complex" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:15 pm | Selected from Poster Abstracts: Elaine Dunleavy (National University of Ireland Galway, Ireland) "Novel Roles for ATP Synthase at Centromeres in Drosophila Male Meiosis" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Julie Cooper (National Cancer Institute, NIH, USA) "Centromeres Impersonate Telomeres in Controlling
the Initiation of Mitotic Spindle Assembly" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Arshad Desai (University of California, San Diego, USA) "A Mechanism for Kinetochore-Microtubule
Attachment Stabilization at Metaphase" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Centromeres: Drivers and Shapers of Genomes |
| Discussion Leader: Kerry Bloom (University of North Carolina at Chapel Hill, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Michael Lampson (University of Pennsylvania, USA) "Violation of Mendel's First Law: Cell Biological Mechanisms of
Meiotic Drive" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Harmit Malik (Fred Hutchinson Cancer Research Center, USA) "Causes and Consequences of Genetic Innovation in
Centromeric Histones: A Drosophila Perspective" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Coffee Break |
10:35 am - 10:45 am | Selected from Poster Abstracts: Paul Maddox (University of North Carolina at Chapel Hill, USA) "Centromeric Chromatin Imparts Structural Rigidity Required to Regulate Holocentric Chromosome Length" |
10:45 am - 10:55 am | Discussion |
10:55 am - 11:15 am | Kelly Dawe (University of Georgia, USA) "The Kindr
Complex, a Novel Kinesin Family, Causes Ectopic Centromere Activity and Meiotic
Drive in Maize" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Selected from Poster Abstracts: Ines Drinnenberg (UMR 3664, Institut Curie, France) "Overcoming AbCENS: Recurrent Loss of CenH3 in Holocentric Insects" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Barbara Mellone (University of Connecticut, USA) "Epigenetic Specification of Rapidly Evolving Centromeres" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genomics and Sequence-Dependent Centromere Function |
| Discussion Leader: Munira Basrai (National Cancer Institute, NIH, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Karen Miga (University of California, Santa Cruz, USA) "CENcode: Genetic and Epigenetic Annotation of Human Centromeres" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Michael Freitag (Oregon State University, USA) "Comparative Biology of Centromeric DNA and
Kinetochores of Filamentous Fungi" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:45 pm | Selected from Poster Abstracts: Qianhua Dong (New York University, USA) "Position Effects in the Peri-Centromeric Repeats May Contribute to CENP-A Positioning" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Steven Henikoff (Fred Hutchinson Cancer Research Center, USA) "Insights into Sequence Organization and
Evolution of Satellite DNA from Single-Molecule Sequencing" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Centromere and Kinetochore Dynamics |
| Discussion Leader: Sylvia Erhardt (ZMBH, Universität Heidelberg, Germany) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Patrick Heun (University of Edinburgh, United Kingdom) "Dissecting the Epigenetic Inheritance of the Centromere-Specific Histone CENP-A" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Selected from Poster Abstracts: Gulsah Pekgoz Altunkaya (Research Institute of Molecular Pathology, Austria) "CCAN Assembly Configures Composite Binding Interfaces to Promote Crosslinking of NDC80 Complexes at the Kinetochore" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:25 am | Coffee Break |
10:25 am - 10:45 am | Ajit Joglekar (University of Michigan, USA) "eSAC: An Ectopic and Titratable Spindle Assembly Checkpoint" |
10:45 am - 10:55 am | Discussion |
10:55 am - 11:05 am | Selected from Poster Abstracts: Natascha Kunzel (Heinrich-Heine-Universität Düsseldorf, Germany) "A Novel Regulator of the Kinetochore-Microtubule Interface: Inositol Pyrophosphates" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Tatsuo Fukagawa (Osaka University, Japan) "Epigenetic Regulation of Centromere Specification and Kinetochore Assembly" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Edward Hinchcliffe (Hormel Institute, University of Minnesota, USA) "Monitoring and Suppressing Aneuploidy via Histone H3.3 Phosphorylation" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Selected from Poster Abstracts: Hironori Funabiki (Rockefeller University, USA) "Dissecting the Molecular Function of a Novel Chromatin Factor CDCA7 Linked to Immunodeficiency-Centromeric Instability-Facial Anomalies (ICF) Syndrome" |
12:15 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Centromere Epigenetics |
| Discussion Leader: Steven Friedman (Oregon State University, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Jiming Jiang (University of Wisconsin-Madison, USA) "Recurrent Activation of a Latent Centromere in Maize" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | William Earnshaw (University of Edinburgh, United Kingdom) "From Cold White Hands to PREditOR and Synthetic Epigenetics" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:45 pm | Selected from Poster Abstracts: Daniele Fachinetti (Institut Curie, France) "CENP-B-Dependent Stabilization of Kinetochore Nucleation Makes CENP-A Dispensible for Maintaining Centromere Function" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | James Birchler (University of Missouri, USA) "Centromere Inactivation and De Novo Formation in
Maize" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Non-Coding Elements Involved in Centromere Function |
| Discussion Leader: Shannon McNulty (Duke University, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Rachel O'Neill (University of Connecticut, USA) "Retroelements and Noncoding RNAs Linked to Centromere Turnover During Species Evolution" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Selected from Poster Abstracts: Whitney Johnson (Stanford University, USA) "RNA-Dependent Heterochromatin Regulation in Human Cells" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Sylvia Erhardt (ZMBH, Universität Heidelberg, Germany) "Epigenetic Regulation of Centromeres by
Non-Coding RNAs" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:10 am | Selected from Poster Abstracts: Yan Yu Charmaine Wong (The University of Hong Kong, Hong Kong SAR China) "Determining the Mechanism of CSR-1 RNAi Pathway in Organizing Holocentromere in Caenorhabditis elegans" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Robin Allshire (Wellcome Trust Centre for Cell Biology, United Kingdom) "Dynamics of Centromeric Chromatin Domains" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Selected from Poster Abstracts: Michael Blower (Massachusetts General Hospital, USA) "Centromeric Transcription Regulates Aurora-B Localization and Activation" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Selected from Poster Abstracts: Nick Gilbert (MRC Human Genetics Unit, United Kingdom) "Centromeres Have a Disrupted Chromatin Structure, Generated by Transcription" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Control of Centromeric
Chromatin |
| Discussion Leader: Arshad Desai (University of California, San Diego, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Daniel Foltz (Northwestern University, USA) "Methylation of CENP-A Is an Essential Feature of the CENP-A Amino Terminus" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:15 pm | Selected from Poster Abstracts: Ana Stankovic (Fundacao Calouste Gulbenkian, Instituto Gulbenkian de Ciência, Portugal) "A Dual Inhibitory Mechanism Restricts Centromeric Chromatin Assembly to G1 Phase" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Munira Basrai (National Cancer Institute, NIH, USA) "Molecular Mechanisms Regulating Localization and
Proteolysis of Centromeric Histone H3 Variant for Genome Stability" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Ben Black (University of Pennsylvania, USA) "Centromeric Chromatin Is Built to Last" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |