Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Centromeres: Genetic and Epigenetic Control of Chromosome Segregation
Discussion Leader: Aaron Straight (Stanford University School of Medicine, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Don Cleveland (Ludwig Institute for Cancer Research, USA)
"DNA Replication-Mediated Error Correction for Maintaining Centromere Identity"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Robin Allshire (Wellcome Centre for Cell Biology, University of Edinburgh, United Kingdom)
"The Epigenetic Regulation of Centromere Establishment and Maintenance"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Centromere Biophysics and Structure
Discussion Leader: Nikolina Sekulic (University of Oslo, Norway)
9:00 am - 9:20 am
Stephen Harrison (Harvard Medical School, USA) and Stephen Hinshaw (Harvard Medical School, USA)
"Structure of a Yeast Kinetochore"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Hitoshi Kurumizaka (University of Tokyo, Japan)
"The Contribution of CENP-A into Centromeric Chromatin Architecture"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
Selected from Poster Abstracts: Uhn-soo Cho (University of Michigan Medical School, USA)
"Mis16 Switches Function from a Histone H4 Chaperone to a CENP-A cnp1-Specific Assembly Factor Through Eic1 Interaction"
10:40 am - 10:45 am
Discussion
10:45 am - 11:05 am
Andrea Musacchio (Max Planck Institute of Molecular Physiology, Germany)
"The Centromere-Kinetochore Interface: For Crucial Details, Consult the CENP-C Blueprint"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Ekaterina Grishchuk (Perelman School of Medicine, University of Pennsylvania, USA)
"Ndc80 Complex as an Intrinsic Regulator of Molecular Friction at Mitotic Kinetochores"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Stefan Westermann (University of Duisberg-Essen, Germany)
"Assembly of the Inner Kinetochore"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Sylvia Erhardt (ZMBH, Universität Heidelberg, Germany) and Barbara Mellone (University of Connecticut, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Centromere Function in Disease
Discussion Leader: Munira Basrai (National Cancer Institute, NIH, USA)
7:30 pm - 7:50 pm
Claire Francastel (University of Paris Diderot, CNRS, France)
"Centromere Transcription in Stress and Disease: The Good and the Bad"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Selected from Poster Abstracts: Roshan Shrestha (National Institutes of Health, USA)
"Consequences and Causes of CENP-A Mislocalization in Human Cells"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Yamini Dalal (National Cancer Institute, NIH, USA)
"CENP-A Promiscuously Invades H3.3 Chaperone Pathways to Drive Chromosomal Instability in Human Cancer Cells"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Jennifer Gerton (Stowers Institute for Medical Research, USA)
"Human Centromere Repeat Instability in Cancer"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Gary Karpen (Lawrence Berkeley National Laboratory, USA)
"The Persistence of Neanderthal Centromeres"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mitotic and Meiotic Centromere Functions
Discussion Leader: Barbara Mellone (University of Connecticut, USA)
9:00 am - 9:20 am
Elaine Dunleavy (National University of Ireland Galway, Ireland)
"Centromere Assembly and Functions in Germ Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ben Black (University of Pennsylvania, USA)
"The Balance of Epigenetics and Genetics at the Centromere"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
Selected from Poster Abstracts: Maiko Kitaoka (University of California, Berkeley, USA)
"Investigating Centromere Incompatibility as the Basis of Chromosome Segregation Defects in Inviable Xenopus Hybrids"
10:40 am - 10:45 am
Discussion
10:45 am - 11:05 am
Kelly Dawe (University of Georgia, USA)
"Mechanisms of Meiotic Drive"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Takashi Akera (University of Pennsylvania, USA)
"Microtubule Destabilizing Activity Defines the Directionality of Centromere Drive"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Julia Cooper (National Cancer Institute, NIH, USA) and Haitong Hou (National Cancer Institute, NIH, USA)
"Why Centromeres Fall Apart on Meiotic Entry, and How Telomeres Put Them Back Together"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Centromere Genomics and Evolution
Discussion Leader: Harmit Malik (Fred Hutchinson Cancer Research Center, USA)
7:30 pm - 7:50 pm
Bungo Akiyoshi (University of Oxford, United Kingdom)
"Unique Approaches to Building Centromeres and Kinetochores"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Selected from Poster Abstracts: Fei Li (New York University, USA)
"Heterochromatin Regulate Centromeres by Protecting CENP-A from Ubiquitin-Mediated Degradation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Karen Miga (University of California, Santa Cruz, USA)
"New Approaches to the Genomics of Human Centromeres"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Simona Giunta (The Rockefeller University, USA)
"Maintenance of Centromere Repeats Stability During S-Phase"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
James Birchler (University of Missouri, USA)
"Studies on the Mitotic Drive Mechanism of the Maize Supernumerary B Chromosome"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Centromere and Kinetochore Dynamics
Discussion Leader: Kevin Sullivan (National University of Ireland Galway, Ireland)
9:00 am - 9:20 am
Elena Giulotto (University of Pavia, Italy)
"Molecular Organization and Evolution of Satellite-Free Centromeres in the Genus Equus Model System"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kerry Bloom (University of North Carolina at Chapel Hill, USA)
"Mechanics and Modeling of Centromeres"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Iain Cheeseman (Whitehead Institute / Massachusetts Institute of Technology, USA)
"Modulating Centromere Propagation in Diverse Physiological Contexts"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Selected from Poster Abstracts: Ann Ehrenhofer-Murray (Humboldt University of Berlin, Germany)
"Regulation of Centromere Function in Saccharomyces cerevisiae by the ATAD2 Homolog Yta7"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Arshad Desai (University of California, San Diego, USA)
"Standing to Attention: Kinetochore Dynein Orients Chromosomes for Proper Segregation"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Ajit Joglekar (University of Michigan, USA)
"Coordination of Error Correction and SAC Silencing in the Yeast Kinetochore"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Sue Biggins (Fred Hutchinson Cancer Research Center, USA)
"Regulation of Kinetochore Assembly"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Control of Centromeric Chromatin
Discussion Leader: Paul Maddox (University of North Carolina at Chapel Hill, USA)
7:30 pm - 7:50 pm
Daniele Fachinetti (Institut Curie, France)
"Addicted to Repetition: Centromeric DNA in Centromere Specification and Function"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Guohong Li (National Laboratory of Biomacromolecules, Chinese Academy of Sciences, China)
"Phosphorylation of CENP-A at Ser68 Regulates Its Deposition and Homeostasis During the Cell Cycle"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Hiroshi Masumoto (Kazusa DNA Research Institute, Japan)
"De Novo Establishment and Epigenetic Maintenance of Centromere Chromatin on Alpha-Satellite DNA"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Barbara Mellone (University of Connecticut, USA)
"Defining the Sequence and Organization of the Drosophila Centromere"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Non-Coding Elements Involved in Centromere Function
Discussion Leader: Michael Blower (Massachusetts General Hospital, USA)
9:00 am - 9:20 am
Genevieve Almouzni (Institut Curie / CNRS, France)
"Chaperone Activities Governing Centromere Formation and Maintenance"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Selected from Poster Abstracts: Dawn Carone (Swarthmore College, USA)
"Expression of Pericentric Satellite RNA Leads to Aggregation of Chromatin Regulatory Proteins and Cell Division Defects"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Selected from Poster Abstracts: Samuel Corless (University of Heidelberg, Germany)
"Sorting Through Junk: Dissecting Chromatin at Centromeric Repetitive DNA"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Christophe Escudé (Muséum National d'Histoire Naturelle, France)
"Insights into Alpha Satellite DNA Evolution from Targeted High-Throughput-Sequencing"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Selected from Poster Abstracts: Karen Wing Yee Yuen (The University of Hong Kong, Hong Kong SAR China)
"Point Centromere Activity Requires an Optimal Level of Centromeric Non-Coding RNA"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
Selected from Poster Abstracts: Carlos Perea (Massachusetts General Hospital, USA)
"Regulation of Centromere Transcription by the Cohesin Ring Complex"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Beth Sullivan (Duke University, USA)
"Alpha Satellite Variation and Transcriptional Control of Centromere Function"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Catherine Naughton (MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom)
"Centromeres Have a Transcription Dependent Disrupted Chromatin Structure"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Patrick Heun (Wellcome Trust Centre of Cell Biology, University of Edinburgh, United Kingdom)
"Epigenetic Inheritance of Centromere Identity in a Heterologous System"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Centromere Epigenetics
Discussion Leader: Hironori Funabiki (Rockefeller University, USA)
7:30 pm - 7:50 pm
Daniel Foltz (Northwestern University, USA)
"Retention of Centromeric Nucleosomes During S-Phase"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Tatsuo Fukagawa (Osaka University, Japan)
"Centromere Dynamics During Mitotic Progression"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Lars Jansen (Gulbenkian Institute for Science, Portugal)
"CENP-A Assembly and Stable Transmission Across the Cell Cycle"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
William Earnshaw (University of Edinburgh, United Kingdom)
"Probing the Role of Heterochromatin at Centromeres"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure