Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Centromeres in Evolution
Discussion Leader: Dawn Carone (Swarthmore College, USA)
3:45 pm - 4:15 pm
Harmit Malik (Fred Hutchinson Cancer Research Center, USA)
"Genetic Conflicts Shape Centromeres and Centromeric Proteins"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unwrapping Epigenetics at the Centromere
Discussion Leader: Gary Karpen (Lawrence Berkeley National Laboratory, USA)
7:30 pm - 7:50 pm
Jitendra Thakur (Fred Hutchinson Cancer Research Center, USA)
"Structural Variations of the Human Centromeric Chromatin Complex"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Eftychia Kyriacou (Wellcome Trust Centre for Cell Biology, University of Edinburgh, United Kingdom)
"High-Resolution Mapping of Human Centromeric Proteins"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Charles Day (Hormel Institute, University of Minnesota, USA)
"Histone H3.3 Ser31 Phosphorylation Is Required to Prevent Chromosome Instability"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Arunika Das (University of Pennsylvania, USA)
"Mechanisms of Transmitting Centromere Identity Through the Germline"
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Centromere and Kinetochore Dynamics / Mentorship Component: Challenges Facing Biomedical Research
Discussion Leaders: Sue Biggins (Fred Hutchinson Cancer Research Center, USA) and Michael Blower (Massachusetts General Hospital, USA)
9:00 am - 9:15 am
Xue Su (University of Edinburgh, United Kingdom)
"SUMOylation Regulates the Metaphase-Anaphase Transition by Inactivating the Pericentromeric Signaling Hub"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Grace Hamilton (University of Washington, USA)
"Building a Minimal Functional Kinetochore: From Microtubule to Centromere"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Agata Zielinska (Max Planck Institute for Biophysical Chemistry, Germany)
"New Insights into Chromosome and Kinetochore Organization During Mammalian Meiosis"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Challenges Facing Biomedical Research
Girija Goyal (ReFigure, USA)
Fanuel Muindi (Harvard University / The STEM Advocacy Institute, USA)
Sarah Mazzilli (Boston University, USA)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Emerging Concepts in Centromere Control
Discussion Leader: Daniel Foltz (Northwestern University, USA)
1:30 pm - 1:50 pm
Carlos Perea (Massachusetts General Hospital, USA)
"Regulation of Centromere Transcription by the Cohesin Ring Complex"
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:20 pm
Srivarsha Rajshekar (Weill Cornell Graduate School of Medical Sciences, USA)
"Pericentromeric DNA Hypomethylation Elicits an Interferon Response in an Animal Model of ICF Syndrome"
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes